PDB: 243531 resultsInfo pagesStatus searchChemie searchBIRD

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8VML	PRC2_AJ1-450 bound to H3K4me3 Descriptor: AEPB2, EED, EZH2, ... Authors: Cookis, T, Nogales, E. Deposit date: 2024-01-13 Release date: 2025-01-15 Last modified: 2025-03-05 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications. Nat.Struct.Mol.Biol., 32, 2025
8VCF	Crystal structure of Superbinder Src SH2 domain with Cysteine to Serine mutations Descriptor: Isoform 3 of Proto-oncogene tyrosine-protein kinase Src Authors: Hashem, A, Nyovanie, S, Patskovsky, Y, Oltean, N, Krogsgaard, M. Deposit date: 2023-12-14 Release date: 2025-01-29 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Engineered Mutant Src Sh2 Domain To Be Published
7MAW	SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM129 Descriptor: 3C-like proteinase, ethyl (4R)-4-({3-cyclopropyl-N-[(2E)-3-(4-ethynylphenyl)prop-2-enoyl]-L-alanyl}amino)-5-[(3S)-2-oxopyrrolidin-3-yl]pentanoate Authors: Lockbaum, G.J, Schiffer, C.A. Deposit date: 2021-03-31 Release date: 2022-10-12 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.07 Å) Cite: SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM129 To Be Published
7MAV	SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor dFFCit-yne Descriptor: 3C-like proteinase, N-{3-[(prop-2-yn-1-yl)oxy]propanoyl}-D-phenylalanyl-N-[(3S)-6-(carbamoylamino)-2-oxohexan-3-yl]-L-phenylalaninamide Authors: Lockbaum, G.J, Schiffer, C.A. Deposit date: 2021-03-31 Release date: 2022-10-12 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.91 Å) Cite: SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor dFFCit-yne To Be Published
5I5W	X-RAY CRYSTAL STRUCTURE AT 2.40A RESOLUTION OF HUMAN MITOCHONDRIAL BRANCHED CHAIN AMINOTRANSFERASE (BCATM) COMPLEXED WITH A BIARYL AMIDE COMPOUND AND AN INTERNAL ALDIMINE LINKED PLP COFACTOR. Descriptor: 1,2-ETHANEDIOL, Branched-chain-amino-acid aminotransferase, mitochondrial, ... Authors: Somers, D.O. Deposit date: 2016-02-15 Release date: 2016-03-23 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening. J.Med.Chem., 59, 2016
8VOB	H3K36me3-modified nucleosome bound to PRC2_AJ1-450 Descriptor: DNA (157-MER), Histone H2A type 1, Histone H2B 1.1, ... Authors: Cookis, T, Nogales, E. Deposit date: 2024-01-14 Release date: 2025-01-15 Last modified: 2025-03-05 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications. Nat.Struct.Mol.Biol., 32, 2025
5VIG	Crystal structure of anti-Zika antibody Z006 bound to Zika virus envelope protein DIII Descriptor: CITRATE ANION, Fab heavy chain, Fab light chain, ... Authors: Keeffe, J.R, West Jr, A.P, Gristick, H.B, Bjorkman, P.J. Deposit date: 2017-04-16 Release date: 2017-05-03 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (3 Å) Cite: Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico. Cell, 169, 2017
7MAX	SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM137 Descriptor: 3C-like proteinase, D-phenylalanyl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-4-fluoro-L-phenylalaninamide Authors: Lockbaum, G.J, Schiffer, C.A. Deposit date: 2021-03-31 Release date: 2022-10-12 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.98 Å) Cite: SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM137 To Be Published
8VS0	A structural study of selectivity mechanisms for JNK3 and p38 alpha with indazole scaffold probing compounds Descriptor: (4P)-4-[6-fluoro-5-(2-methoxyanilino)-1H-indazol-1-yl]-5-methyl-N-(oxetan-3-yl)thiophene-2-carboxamide, Mitogen-activated protein kinase 10 Authors: Park, H, Feng, Y. Deposit date: 2024-01-23 Release date: 2025-01-29 Method: X-RAY DIFFRACTION (2.46 Å) Cite: A structural study of selectivity mechanisms for JNK3 and p38 alpha with indazole scaffold probing compounds To Be Published
5IP1	Tomato spotted wilt tospovirus nucleocapsid protein Descriptor: Nucleoprotein Authors: Komoda, K, Narita, M, Yamashita, K, Tanaka, I, Yao, M. Deposit date: 2016-03-09 Release date: 2017-03-22 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.703 Å) Cite: Asymmetric Trimeric Ring Structure of the Nucleocapsid Protein of Tospovirus. J. Virol., 91, 2017
8VW9	CryoEM Structure of a FtsH Helical Assembly in the Presence of ATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent zinc metalloprotease FtsH, MAGNESIUM ION, ... Authors: Li, Y, Zhu, J, Zhang, Z, Wang, F, Egelman, E.H, Tezcan, F.A. Deposit date: 2024-01-31 Release date: 2025-01-15 Last modified: 2025-06-11 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Transforming an ATP-dependent enzyme into a dissipative, self-assembling system. Nat.Chem.Biol., 21, 2025
6W8T	Crystal structure of metacaspase 4 from Arabidopsis (microcrystals treated with calcium) Descriptor: Metacaspase-4, SULFATE ION Authors: Zhu, P, Yu, X.H, Wang, C, Zhang, Q, Liu, W, McSweeney, S, Shanklin, J, Lam, E, Liu, Q. Deposit date: 2020-03-21 Release date: 2020-05-20 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structural basis for Ca2+-dependent activation of a plant metacaspase. Nat Commun, 11, 2020
8VWC	CryoEM Structure of a FtsH Helical Assembly in the Aged State Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent zinc metalloprotease FtsH, MAGNESIUM ION, ... Authors: Li, Y, Zhu, J, Zhang, Z, Wang, F, Egelman, E.H, Tezcan, F.A. Deposit date: 2024-01-31 Release date: 2025-01-15 Last modified: 2025-06-11 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Transforming an ATP-dependent enzyme into a dissipative, self-assembling system. Nat.Chem.Biol., 21, 2025
5VKB	Ethylene forming enzyme in complex with manganese, 2-oxoglutarate and argininamide Descriptor: 2-OXOGLUTARIC ACID, 2-oxoglutarate-dependent ethylene/succinate-forming enzyme, ARGININEAMIDE, ... Authors: Fellner, M, Martinez, S, Hu, J, Hausinger, R.P. Deposit date: 2017-04-21 Release date: 2017-08-16 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.139 Å) Cite: Structures and Mechanisms of the Non-Heme Fe(II)- and 2-Oxoglutarate-Dependent Ethylene-Forming Enzyme: Substrate Binding Creates a Twist. J. Am. Chem. Soc., 139, 2017
7MB0	SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM141 Descriptor: 3C-like proteinase, D-phenylalanyl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide Authors: Lockbaum, G.J, Schiffer, C.A. Deposit date: 2021-03-31 Release date: 2022-10-12 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.54 Å) Cite: SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM141 To Be Published
6W0H	Closed-gate KcsA soaked in 5mM KCl/5mM BaCl2 Descriptor: Fab Heavy Chain, Fab Light Chain, POTASSIUM ION, ... Authors: Rohaim, A, Gong, L, Li, J. Deposit date: 2020-02-29 Release date: 2020-07-08 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Open and Closed Structures of a Barium-Blocked Potassium Channel. J.Mol.Biol., 432, 2020
5VP8	I38T mutant of 2009 H1N1 PA Endonuclease Descriptor: 1-[(3R,5S,7R)-1,5,7,9-tetrakis(2-oxopyrrolidin-1-yl)nonan-3-yl]-1,3-dihydro-2H-pyrrol-2-one, MANGANESE (II) ION, Polymerase acidic protein, ... Authors: Kumar, G, White, S.W. Deposit date: 2017-05-04 Release date: 2018-04-11 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors. MBio, 9, 2018
8VVY	Human Cullin-1 in complex with CAND2 Descriptor: Cullin-1, Cullin-associated NEDD8-dissociated protein 2 Authors: Kenny, S, Liu, X, Das, C. Deposit date: 2024-01-31 Release date: 2025-01-29 Last modified: 2025-08-13 Method: ELECTRON MICROSCOPY (3.49 Å) Cite: Molecular mechanisms of CAND2 in regulating SCF ubiquitin ligases. Nat Commun, 16, 2025
7M6N	Full length alpha1 Glycine receptor in presence of 0.1mM Glycine Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, Glycine receptor subunit alphaZ1 Authors: Kumar, A, Chakrapani, S. Deposit date: 2021-03-26 Release date: 2022-08-03 Last modified: 2025-06-04 Method: ELECTRON MICROSCOPY (2.61 Å) Cite: Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs. Nat Commun, 13, 2022
5VL4	Accidental minimum contact crystal lattice formed by a redesigned protein oligomer Descriptor: T33-53H-B Authors: Cannon, K.A, Cascio, D, Sawaya, M.R, Park, R, Boyken, S, King, N, Yeates, T. Deposit date: 2017-04-24 Release date: 2018-05-23 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (4.1 Å) Cite: Design and structure of two new protein cages illustrate successes and ongoing challenges in protein engineering. Protein Sci., 29, 2020
7M6Q	Full length alpha1 Glycine receptor in presence of 1mM Glycine and 32uM Tetrahydrocannabinol State 1 Descriptor: (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, ... Authors: Kumar, A, Chakrapani, S. Deposit date: 2021-03-26 Release date: 2022-08-03 Last modified: 2025-05-28 Method: ELECTRON MICROSCOPY (2.91 Å) Cite: Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs. Nat Commun, 13, 2022
8VWY	Complex structure of mouse C1ql3 with BAI3 Descriptor: Adhesion G protein-coupled receptor B3, CALCIUM ION, Complement C1q-like protein 3 Authors: Miao, Y, Sudhof, T.C. Deposit date: 2024-02-02 Release date: 2025-02-05 Last modified: 2025-08-20 Method: ELECTRON MICROSCOPY (2.78 Å) Cite: Structure of the complex of C1q-like 3 protein with adhesion-GPCR BAI3. Commun Biol, 8, 2025
7M6R	Full length alpha1 Glycine receptor in presence of 1mM Glycine and 32uM Tetrahydrocannabinol State 2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, Glycine receptor subunit alphaZ1 Authors: Kumar, A, Chakrapani, S. Deposit date: 2021-03-26 Release date: 2022-08-03 Last modified: 2025-05-28 Method: ELECTRON MICROSCOPY (3.57 Å) Cite: Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs. Nat Commun, 13, 2022
6WA8	Crystal structure of the E. coli transcription termination factor Rho Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Transcription termination factor Rho Authors: Fan, C, Rees, D.C. Deposit date: 2020-03-24 Release date: 2020-09-16 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Crystal structure of the Escherichia coli transcription termination factor Rho. Acta Crystallogr.,Sect.F, 76, 2020
5I7M	Crystal structure of Y345F mutant of human primase p58 iron-sulfur cluster domain Descriptor: DNA primase large subunit, IRON/SULFUR CLUSTER, SULFATE ION Authors: Salay, L.E, Thompson, M.K, Chazin, W.J. Deposit date: 2016-02-17 Release date: 2017-03-01 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.93 Å) Cite: The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport. Science, 355, 2017

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