7MAW

SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM129

Summary for 7MAW

• Entry DOI: 10.2210/pdb7maw/pdb
• Descriptor: 3C-like proteinase, ethyl (4R)-4-({3-cyclopropyl-N-[(2E)-3-(4-ethynylphenyl)prop-2-enoyl]-L-alanyl}amino)-5-[(3S)-2-oxopyrrolidin-3-yl]pentanoate (3 entities in total)
• Functional Keywords: sars-cov-2, covid-19, covid19 protease, protease inhibitor, covalent inhibitor, complex, hydrolase inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
• Total number of polymer chains: 2
• Total formula weight: 68638.28

Authors

Lockbaum, G.J.,Schiffer, C.A. (deposition date: 2021-03-31, release date: 2022-10-12, Last modification date: 2024-10-16)

• Primary citation: Lockbaum, G.J.,Schiffer, C.A.; SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM129; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.07 Å)