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7MAW

SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM129

Summary for 7MAW
Entry DOI10.2210/pdb7maw/pdb
Descriptor3C-like proteinase, ethyl (4R)-4-({3-cyclopropyl-N-[(2E)-3-(4-ethynylphenyl)prop-2-enoyl]-L-alanyl}amino)-5-[(3S)-2-oxopyrrolidin-3-yl]pentanoate (3 entities in total)
Functional Keywordssars-cov-2, covid-19, covid19 protease, protease inhibitor, covalent inhibitor, complex, hydrolase inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSevere acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
Total number of polymer chains2
Total formula weight68638.28
Authors
Lockbaum, G.J.,Schiffer, C.A. (deposition date: 2021-03-31, release date: 2022-10-12, Last modification date: 2023-10-18)
Primary citationLockbaum, G.J.,Schiffer, C.A.
SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM129
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.07 Å)
Structure validation

223532

PDB entries from 2024-08-07

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