2ONR
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![BU of 2onr by Molmil](/molmil-images/mine/2onr) | Crystal structure of A. fulgidus periplasmic binding protein ModA with bound molybdate | Descriptor: | MAGNESIUM ION, MOLYBDATE ION, NITRATE ION, ... | Authors: | Hollenstein, K, Frei, D.C, Locher, K.P. | Deposit date: | 2007-01-24 | Release date: | 2007-03-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of an ABC transporter in complex with its binding protein. Nature, 446, 2007
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2F1M
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5AZS
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![BU of 5azs by Molmil](/molmil-images/mine/5azs) | |
2D6Y
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![BU of 2d6y by Molmil](/molmil-images/mine/2d6y) | Crystal Structure of transcriptional factor SCO4008 from Streptomyces coelicolor A3(2) | Descriptor: | L(+)-TARTARIC ACID, putative tetR family regulatory protein | Authors: | Hayashi, T, Tanaka, Y, Sakai, N, Yao, M, Tamura, T, Tanaka, I. | Deposit date: | 2005-11-15 | Release date: | 2006-10-31 | Last modified: | 2013-09-04 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | SCO4008, a Putative TetR Transcriptional Repressor from Streptomyces coelicolor A3(2), Regulates Transcription of sco4007 by Multidrug Recognition. J.Mol.Biol., 425, 2013
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6F7C
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![BU of 6f7c by Molmil](/molmil-images/mine/6f7c) | TUBULIN-Compound 12 complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3,4,5-trimethoxy-~{N}-[(~{E})-naphthalen-1-ylmethylideneamino]benzamide, CALCIUM ION, ... | Authors: | Muehlethaler, T, Prota, A.E, Steinmetz, M.O. | Deposit date: | 2017-12-08 | Release date: | 2018-12-19 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.002 Å) | Cite: | Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia. Iscience, 21, 2019
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4ZZL
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![BU of 4zzl by Molmil](/molmil-images/mine/4zzl) | MexR R21W derepressor mutant causing multidrug resistance in P. aeruginosa by mexAB-oprM efflux pump expression | Descriptor: | GLYCEROL, MULTIDRUG RESISTANCE OPERON REPRESSOR | Authors: | Anandapadamanaban, M, Pilstal, R, Ziauddin, J.M.E, Moche, M, Wallner, B, Sunnerhagen, M. | Deposit date: | 2015-04-10 | Release date: | 2016-07-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Mutation-Induced Population Shift in the Mexr Conformational Ensemble Disengages DNA Binding: A Novel Mechanism for Marr Family Derepression. Structure, 24, 2016
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1T5E
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![BU of 1t5e by Molmil](/molmil-images/mine/1t5e) | The structure of MexA | Descriptor: | D-Glyceraldehyde, GLYCEROL, Multidrug resistance protein mexA | Authors: | Higgins, M.K, Bokma, E, Koronakis, E, Hughes, C, Koronakis, V. | Deposit date: | 2004-05-04 | Release date: | 2004-05-18 | Last modified: | 2020-07-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of the periplasmic component of a bacterial drug efflux pump Proc.Natl.Acad.Sci.USA, 101, 2004
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8RQ3
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7OTI
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![BU of 7oti by Molmil](/molmil-images/mine/7oti) | Structure of ABCB1/P-glycoprotein in apo state | Descriptor: | Multidrug resistance protein 1A | Authors: | Ford, R.C, Barbieri, A, Thonghin, N, Shafi, T, Prince, S.M, Collins, R.F. | Deposit date: | 2021-06-10 | Release date: | 2021-12-08 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structure of ABCB1/P-Glycoprotein in the Presence of the CFTR Potentiator Ivacaftor. Membranes (Basel), 11, 2021
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7OTG
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![BU of 7otg by Molmil](/molmil-images/mine/7otg) | Structure of ABCB1/P-glycoprotein in the presence of the CFTR potentiator ivacaftor | Descriptor: | Multidrug resistance protein 1A, N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide | Authors: | Ford, R.C, Barbieri, A, Thonghin, N, Shafi, T, Prince, S.M, Collins, R.F. | Deposit date: | 2021-06-10 | Release date: | 2021-12-08 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (5.4 Å) | Cite: | Structure of ABCB1/P-Glycoprotein in the Presence of the CFTR Potentiator Ivacaftor. Membranes (Basel), 11, 2021
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8RQ4
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4KSD
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![BU of 4ksd by Molmil](/molmil-images/mine/4ksd) | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain | Descriptor: | Multidrug resistance protein 1A, R2 protein | Authors: | Ward, A, Szewczyk, P, Grimard, V, Lee, C.-W, Martinez, L, Doshi, R, Caya, A, Villaluz, M, Pardon, E, Cregger, C, Swartz, D.J, Falson, P, Urbatsch, I, Govaerts, C, Steyaert, J, Chang, G. | Deposit date: | 2013-05-17 | Release date: | 2013-07-31 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (4.1001 Å) | Cite: | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain. Proc.Natl.Acad.Sci.USA, 110, 2013
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4KSC
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![BU of 4ksc by Molmil](/molmil-images/mine/4ksc) | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain | Descriptor: | Multidrug resistance protein 1A | Authors: | Ward, A, Szewczyk, P, Grimard, V, Lee, C.-W, Martinez, L, Doshi, R, Caya, A, Villaluz, M, Pardon, E, Cregger, C, Swartz, D.J, Falson, P, Urbatsch, I, Govaerts, C, Steyaert, J, Chang, G. | Deposit date: | 2013-05-17 | Release date: | 2013-07-31 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain. Proc.Natl.Acad.Sci.USA, 110, 2013
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4KSB
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![BU of 4ksb by Molmil](/molmil-images/mine/4ksb) | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain | Descriptor: | Multidrug resistance protein 1A | Authors: | Ward, A, Szewczyk, P, Grimard, V, Lee, C.-W, Martinez, L, Doshi, R, Caya, A, Villaluz, M, Pardon, E, Cregger, C, Swartz, D.J, Falson, P, Urbatsch, I, Govaerts, C, Steyaert, J, Chang, G. | Deposit date: | 2013-05-17 | Release date: | 2013-07-31 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.8001 Å) | Cite: | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain. Proc.Natl.Acad.Sci.USA, 110, 2013
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8SWN
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6RAN
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![BU of 6ran by Molmil](/molmil-images/mine/6ran) | Heterodimeric ABC exporter TmrAB in inward-facing wide conformation | Descriptor: | Multidrug resistance ABC transporter ATP-binding and permease protein, Nanobody Nb9F10 | Authors: | Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R. | Deposit date: | 2019-04-06 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature, 571, 2019
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6GDI
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![BU of 6gdi by Molmil](/molmil-images/mine/6gdi) | Structure of P-glycoprotein(ABCB1) in the post-hydrolytic state | Descriptor: | Multidrug resistance protein 1A | Authors: | Ford, R.C, Thonghin, N, Collins, R.F, Barbieri, A, Shafi, T, Siebert, A. | Deposit date: | 2018-04-23 | Release date: | 2018-05-23 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (7.9 Å) | Cite: | Novel features in the structure of P-glycoprotein (ABCB1) in the post-hydrolytic state as determined at 7.9 angstrom resolution. Bmc Struct.Biol., 18, 2018
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7O9W
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![BU of 7o9w by Molmil](/molmil-images/mine/7o9w) | Encequidar-bound human P-glycoprotein in complex with UIC2-Fab | Descriptor: | Multidrug resistance protein 1, UIC2 Fab-fragment heavy chain, UIC2 Fab-fragment light chain, ... | Authors: | Nosol, K, Locher, K.P. | Deposit date: | 2021-04-17 | Release date: | 2022-01-12 | Last modified: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations. J.Med.Chem., 65, 2022
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4Q9J
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![BU of 4q9j by Molmil](/molmil-images/mine/4q9j) | P-glycoprotein cocrystallised with QZ-Val | Descriptor: | Multidrug resistance protein 1A, N-{[5-AMINO-1-(5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1H-IMIDAZOL-4-YL]CARBONYL}-L-ASPARTIC ACID | Authors: | McGrath, A.P, Szewczyk, P, Chang, G. | Deposit date: | 2014-05-01 | Release date: | 2015-03-04 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein. Acta Crystallogr.,Sect.D, 71, 2015
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4Q9H
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![BU of 4q9h by Molmil](/molmil-images/mine/4q9h) | P-glycoprotein at 3.4 A resolution | Descriptor: | Multidrug resistance protein 1A | Authors: | McGrath, A.P, Szewczyk, P, Chang, G. | Deposit date: | 2014-05-01 | Release date: | 2015-03-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein. Acta Crystallogr.,Sect.D, 71, 2015
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8PX7
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![BU of 8px7 by Molmil](/molmil-images/mine/8px7) | Structure of Bacterial Multidrug Efflux transporter AcrB, solved at wavelength 3.02 A | Descriptor: | Multidrug efflux pump subunit AcrB | Authors: | El Omari, K, Duman, R, Mykhaylyk, V, Orr, C, Qu, F, Beis, K, Wagner, A. | Deposit date: | 2023-07-22 | Release date: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Experimental phasing opportunities for macromolecular crystallography at very long wavelengths. Commun Chem, 6, 2023
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1YC9
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![BU of 1yc9 by Molmil](/molmil-images/mine/1yc9) | The crystal structure of the outer membrane protein VceC from the bacterial pathogen Vibrio cholerae at 1.8 resolution | Descriptor: | MERCURY (II) ION, multidrug resistance protein, octyl beta-D-glucopyranoside | Authors: | Federici, L, Du, D, Walas, F, Matsumura, H, Fernandez-Recio, J, McKeegan, K.S, Borges-Walmsley, M.I, Luisi, B.F, Walmsley, A.R. | Deposit date: | 2004-12-22 | Release date: | 2005-03-01 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The crystal structure of the outer membrane protein VCEC from the bacterial pathogen vibrio cholerae at 1.8 A resolution J.Biol.Chem., 280, 2005
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3IAO
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6IKM
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![BU of 6ikm by Molmil](/molmil-images/mine/6ikm) | Crystal structure of SpuE-Spermidine in complex with ScFv5 | Descriptor: | Polyamine transport protein, SPERMIDINE, SULFATE ION, ... | Authors: | Wu, D, Sun, X. | Deposit date: | 2018-10-16 | Release date: | 2019-12-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.398 Å) | Cite: | A Potent Anti-SpuE Antibody Allosterically Inhibits Type III Secretion System and Attenuates Virulence of Pseudomonas Aeruginosa. J.Mol.Biol., 431, 2019
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3MEX
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![BU of 3mex by Molmil](/molmil-images/mine/3mex) | Crystal structure of MexR in oxidized state | Descriptor: | Multidrug resistance operon repressor | Authors: | Chen, H, Yi, C, Zhang, J, Zhang, W, Yang, C.-G, He, C. | Deposit date: | 2010-04-01 | Release date: | 2010-07-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR Embo Rep., 11, 2010
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