4ZZL
MexR R21W derepressor mutant causing multidrug resistance in P. aeruginosa by mexAB-oprM efflux pump expression
Summary for 4ZZL
| Entry DOI | 10.2210/pdb4zzl/pdb |
| Descriptor | MULTIDRUG RESISTANCE OPERON REPRESSOR, GLYCEROL (3 entities in total) |
| Functional Keywords | transcription, mexr, mexab-oprm efflux pump, md simulation |
| Biological source | PSEUDOMONAS AERUGINOSA |
| Total number of polymer chains | 2 |
| Total formula weight | 36910.20 |
| Authors | Anandapadamanaban, M.,Pilstal, R.,Ziauddin, J.M.E.,Moche, M.,Wallner, B.,Sunnerhagen, M. (deposition date: 2015-04-10, release date: 2016-07-27, Last modification date: 2024-01-10) |
| Primary citation | Anandapadamanaban, M.,Pilstal, R.,Andresen, C.,Trewhella, J.,Moche, M.,Wallner, B.,Sunnerhagen, M. Mutation-Induced Population Shift in the Mexr Conformational Ensemble Disengages DNA Binding: A Novel Mechanism for Marr Family Derepression. Structure, 24:1311-, 2016 Cited by PubMed: 27427478DOI: 10.1016/J.STR.2016.06.008 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.19 Å) |
Structure validation
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