4ZZL

MexR R21W derepressor mutant causing multidrug resistance in P. aeruginosa by mexAB-oprM efflux pump expression

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	MULTIDRUG RESISTANCE OPERON REPRESSOR	polymer	158	18363.0	2	UniProt (P52003) Pfam (PF01047)	PSEUDOMONAS AERUGINOSA	MEXR
2	C, D (B)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
3	E, F (A, B)	water	water		18.0	126	Chemie (HOH)

Sequence modifications

A, B: 5 - 139 (UniProt: P52003)

PDB	External Database	Details
Met -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
Gly -9	-	expression tag
Val -8	-	expression tag
Asp -7	-	expression tag
Leu -6	-	expression tag
Gly -5	-	expression tag
Thr -4	-	expression tag
Glu -3	-	expression tag
Asn -2	-	expression tag
Leu -1	-	expression tag
Tyr 0	-	expression tag
Phe 1	-	expression tag
Gln 2	-	expression tag
Ser 3	-	expression tag
Met 4	-	expression tag
Trp 21	Arg 21	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	36726.0
Non-Polymers*	Number of molecules	2
	Total formula weight	184.2
All*	Total formula weight	36910.2

*Water molecules are not included.