4Q9J

P-glycoprotein cocrystallised with QZ-Val

Summary for 4Q9J

Related4Q9H 4Q9I 4Q9K 4Q9L
Related PRD IDPRD_001235
DescriptorMultidrug resistance protein 1A, N-{[5-AMINO-1-(5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1H-IMIDAZOL-4-YL]CARBONYL}-L-ASPARTIC ACID (2 entities in total)
Functional Keywordsmembrane protein, transporter, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceMus musculus (mouse)
Cellular locationCell membrane; Multi-pass membrane protein P21447
Total number of polymer chains4
Total molecular weight144198.37
Authors
McGrath, A.P.,Szewczyk, P.,Chang, G. (deposition date: 2014-05-01, release date: 2015-03-04, Last modification date: 2015-03-18)
Primary citation
Szewczyk, P.,Tao, H.,McGrath, A.P.,Villaluz, M.,Rees, S.D.,Lee, S.C.,Doshi, R.,Urbatsch, I.L.,Zhang, Q.,Chang, G.
Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein.
Acta Crystallogr.,Sect.D, 71:732-741, 2015
PubMed: 25760620 (PDB entries with the same primary citation)
DOI: 10.1107/S1399004715000978
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.285200.8%1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution