P-glycoprotein cocrystallised with QZ-Ala

Summary for 4Q9I

Related4Q9H 4Q9J 4Q9K 4Q9L
Related PRD IDPRD_001236
DescriptorMultidrug resistance protein 1A, (30F)A(30F)A(30F)A Peptide (2 entities in total)
Functional Keywordsmembrane protein, transporter, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceMus musculus (mouse)
Cellular locationCell membrane; Multi-pass membrane protein P21447
Total number of polymer chains3
Total molecular weight143270.58
McGrath, A.P.,Szewczyk, P.,Chang, G. (deposition date: 2014-05-01, release date: 2015-03-04, Last modification date: 2016-05-25)
Primary citation
Szewczyk, P.,Tao, H.,McGrath, A.P.,Villaluz, M.,Rees, S.D.,Lee, S.C.,Doshi, R.,Urbatsch, I.L.,Zhang, Q.,Chang, G.
Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein.
Acta Crystallogr.,Sect.D, 71:732-741, 2015
PubMed: 25760620 (PDB entries with the same primary citation)
DOI: 10.1107/S1399004715000978
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.305200.5%5.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload