7OTG

Structure of ABCB1/P-glycoprotein in the presence of the CFTR potentiator ivacaftor

Summary for 7OTG

Entry DOI	10.2210/pdb7otg/pdb
EMDB information	13059
Descriptor	Multidrug resistance protein 1A, N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (2 entities in total)
Functional Keywords	abcb1, abc transporters, membrane proteins, ivacaftor, mdr1, multidrug resistance, cryo-em, membrane protein
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	142270.37
Authors	Ford, R.C.,Barbieri, A.,Thonghin, N.,Shafi, T.,Prince, S.M.,Collins, R.F. (deposition date: 2021-06-10, release date: 2021-12-08, Last modification date: 2024-07-17)
Primary citation	Barbieri, A.,Thonghin, N.,Shafi, T.,Prince, S.M.,Collins, R.F.,Ford, R.C. Structure of ABCB1/P-Glycoprotein in the Presence of the CFTR Potentiator Ivacaftor. Membranes (Basel), 11:-, 2021 Cited by PubMed: 34940424 DOI: 10.3390/membranes11120923 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (5.4 Å)

Structure validation