7OTG
Structure of ABCB1/P-glycoprotein in the presence of the CFTR potentiator ivacaftor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Multidrug resistance protein 1A | polymer | 1284 | 141877.9 | 1 | UniProt (P21447) Pfam (PF00664) Pfam (PF00005) | Mus musculus (Mouse) | ATP-binding cassette sub-family B member 1A,MDR1A,Multidrug resistance protein 3,P-glycoprotein 3 |
| 2 | B (A) | N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide | non-polymer | 392.5 | 1 | Chemie (VX7) |
Sequence modifications
A: 1 - 1276 (UniProt: P21447)
| PDB | External Database | Details |
|---|---|---|
| Leu 1277 | - | expression tag |
| Glu 1278 | - | expression tag |
| His 1279 | - | expression tag |
| His 1280 | - | expression tag |
| His 1281 | - | expression tag |
| His 1282 | - | expression tag |
| His 1283 | - | expression tag |
| His 1284 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 141877.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 392.5 | |
| All* | Total formula weight | 142270.4 |
