7O9W
Encequidar-bound human P-glycoprotein in complex with UIC2-Fab
Summary for 7O9W
Entry DOI | 10.2210/pdb7o9w/pdb |
EMDB information | 12765 |
Descriptor | Multidrug resistance protein 1, UIC2 Fab-fragment light chain, UIC2 Fab-fragment heavy chain, ... (4 entities in total) |
Functional Keywords | abcb1, mdr1, p-glycoprotein, nanodisc, encequidar, transport protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 191712.59 |
Authors | Nosol, K.,Locher, K.P. (deposition date: 2021-04-17, release date: 2022-01-12, Last modification date: 2022-01-26) |
Primary citation | Urgaonkar, S.,Nosol, K.,Said, A.M.,Nasief, N.N.,Bu, Y.,Locher, K.P.,Lau, J.Y.N.,Smolinski, M.P. Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations. J.Med.Chem., 65:191-216, 2022 Cited by PubMed: 34928144DOI: 10.1021/acs.jmedchem.1c01272 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.5 Å) |
Structure validation
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