7O9W
Encequidar-bound human P-glycoprotein in complex with UIC2-Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Multidrug resistance protein 1 | polymer | 1280 | 141628.8 | 1 | UniProt (P08183) Pfam (PF00664) Pfam (PF00005) In PDB | Homo sapiens (Human) | ATP-binding cassette sub-family B member 1,P-glycoprotein 1 |
| 2 | B | UIC2 Fab-fragment light chain | polymer | 220 | 24321.0 | 1 | Mus musculus | ||
| 3 | C | UIC2 Fab-fragment heavy chain | polymer | 225 | 24381.3 | 1 | Mus musculus | ||
| 4 | A | ~{N}-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1~{H}-isoquinolin-2-yl)ethyl]phenyl]-1,2,3,4-tetrazol-5-yl]-4,5-dimethoxy-phenyl]-4-oxidanylidene-2,3-dihydrochromene-2-carboxamide | non-polymer | 690.7 | 2 | Chemie (V5Q) |
Sequence modifications
A: 1 - 1280 (UniProt: P08183)
| PDB | External Database | Details |
|---|---|---|
| Ala 893 | Ser 893 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 190331.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1381.5 | |
| All* | Total formula weight | 191712.6 |
