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8XXL
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BU of 8xxl by Molmil
Cryo-EM structure of the human 40S ribosome with PDCD4
Descriptor: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
Authors:Ye, X, Huang, Z, Li, Y, Wang, M, Cheng, J.
Deposit date:2024-01-18
Release date:2024-05-01
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.
Cell Res., 2024
8XXM
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BU of 8xxm by Molmil
Cryo-EM structure of the human 40S ribosome with PDCD4 and eIF3G
Descriptor: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
Authors:Ye, X, Huang, Z, Li, Y, Wang, M, Cheng, J.
Deposit date:2024-01-18
Release date:2024-05-01
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.
Cell Res., 2024
8XXN
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BU of 8xxn by Molmil
Cryo-EM structure of the human 43S ribosome with PDCD4
Descriptor: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
Authors:Ye, X, Huang, Z, Li, Y, Wang, M, Cheng, J.
Deposit date:2024-01-18
Release date:2024-05-01
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.
Cell Res., 2024
8RQM
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BU of 8rqm by Molmil
Alpha-synuclein amyloid fibrils
Descriptor: Alpha-synuclein
Authors:Saibil, H.R, Monistrol, J.
Deposit date:2024-01-18
Release date:2024-02-28
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Stepwise recruitment of Hsc70 by DNAJB1 produces ordered arrays primed for bursts of amyloid fibre disassembly
Biorxiv, 2024
8VQ4
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BU of 8vq4 by Molmil
CDK2-CyclinE1 in complex with allosteric inhibitor I-125A.
Descriptor: (8R)-6-(1-benzyl-1H-pyrazole-4-carbonyl)-N-[(2S,3R)-3-(2-cyclohexylethoxy)-1-(methylamino)-1-oxobutan-2-yl]-2-[(1S)-2,2-dimethylcyclopropane-1-carbonyl]-2,6-diazaspiro[3.4]octane-8-carboxamide, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1
Authors:Hirschi, M, Johnson, E, Zhang, Y, Liu, Z, Brodsky, O, Won, S.J, Nagata, A, Petroski, M.D, Majmudar, J.D, Niessen, S, VanArsdale, T, Gilbert, A.M, Hayward, M.M, Stewart, A.E, Nager, A.R, Melillo, B, Cravatt, B.
Deposit date:2024-01-17
Release date:2024-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Expanding the ligandable proteome by paralog hopping with covalent probes.
Biorxiv, 2024
8RPY
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BU of 8rpy by Molmil
Escherichia coli 50S subunit in complex with the antimicrobial peptide Api137
Descriptor: 23S ribosomal RNA, 5S ribosomal RNA, Apidaecins type 137, ...
Authors:Lauer, S, Nikolay, R, Spahn, C.
Deposit date:2024-01-17
Release date:2024-05-22
Method:ELECTRON MICROSCOPY (2.64 Å)
Cite:Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88.
Nat Commun, 15, 2024
8RPZ
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BU of 8rpz by Molmil
Escherichia coli 50S subunit in complex with the antimicrobial peptide Api88 - conformation I
Descriptor: 23S ribosomal RNA, 5S ribosomal RNA, Apidaecins type 88, ...
Authors:Lauer, S, Nikolay, R, Spahn, C.
Deposit date:2024-01-17
Release date:2024-05-22
Method:ELECTRON MICROSCOPY (2.44 Å)
Cite:Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88.
Nat Commun, 15, 2024
8VQ3
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BU of 8vq3 by Molmil
CDK2-CyclinE1 in complex with allosteric inhibitor I-198.
Descriptor: (8R)-N-[(2S,3R)-3-(cyclohexylmethoxy)-1-(morpholin-4-yl)-1-oxobutan-2-yl]-2-[(1S)-2,2-dimethylcyclopropane-1-carbonyl]-6-(1,3-thiazole-5-carbonyl)-2,6-diazaspiro[3.4]octane-8-carboxamide, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1
Authors:Hirschi, M, Johnson, E, Zhang, Y, Liu, Z, Brodsky, O, Won, S.J, Nagata, A, Petroski, M.D, Majmudar, J.D, Niessen, S, VanArsdale, T, Gilbert, A.M, Hayward, M.M, Stewart, A.E, Nager, A.R, Melillo, B, Cravatt, B.
Deposit date:2024-01-17
Release date:2024-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Expanding the ligandable proteome by paralog hopping with covalent probes.
Biorxiv, 2024
8RQ2
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BU of 8rq2 by Molmil
Escherichia coli 50S subunit in complex with the antimicrobial peptide Api88 - conformation III
Descriptor: 23S ribosomal RNA, 5S ribosomal RNA, Apidaecins type 88, ...
Authors:Lauer, S, Nikolay, R, Spahn, C.
Deposit date:2024-01-17
Release date:2024-05-22
Method:ELECTRON MICROSCOPY (2.44 Å)
Cite:Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88.
Nat Commun, 15, 2024
8RQ0
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BU of 8rq0 by Molmil
Escherichia coli 50S subunit in complex with the antimicrobial peptide Api88 - conformation II
Descriptor: 23S ribosomal RNA, 5S ribosomal RNA, Apidaecins type 88, ...
Authors:Lauer, S, Nikolay, R, Spahn, C.
Deposit date:2024-01-17
Release date:2024-05-22
Method:ELECTRON MICROSCOPY (2.44 Å)
Cite:Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88.
Nat Commun, 15, 2024
8VOV
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BU of 8vov by Molmil
Structure of VCP in complex with an ATPase activator and ADP (D2 domains only, hexameric form)
Descriptor: (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase
Authors:Jones, N.H, Urnivicius, L, Kapoor, T.M.
Deposit date:2024-01-16
Release date:2024-06-19
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry.
Proc.Natl.Acad.Sci.USA, 121, 2024
8XW0
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BU of 8xw0 by Molmil
Cryo-EM structure of OSCA3.1-GDN state
Descriptor: CSC1-like protein ERD4, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine
Authors:Zhang, Y, Han, Y.
Deposit date:2024-01-15
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
8XVY
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BU of 8xvy by Molmil
Cryo-EM structure of OSCA3.1-2E(R611E-R619E)-closed/open state
Descriptor: CSC1-like protein ERD4
Authors:Zhang, Y, Han, Y.
Deposit date:2024-01-15
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.71 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
8XVZ
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BU of 8xvz by Molmil
Cryo-EM structure of OSCA3.1-2E(R611E-R619E)-closed/'desensitized' state
Descriptor: CSC1-like protein ERD4
Authors:Zhang, Y, Han, Y.
Deposit date:2024-01-15
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
8VLS
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BU of 8vls by Molmil
Structure of VCP in complex with an ATPase activator (D2 domains only, dodecameric form)
Descriptor: (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, Transitional endoplasmic reticulum ATPase
Authors:Jones, N.H, Urnivicius, L, Kapoor, T.M.
Deposit date:2024-01-12
Release date:2024-06-19
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry.
Proc.Natl.Acad.Sci.USA, 121, 2024
8VLB
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BU of 8vlb by Molmil
Crystal structure of EloBC-VHL-CDO1 complex bound to compound 4 molecular glue
Descriptor: CITRIC ACID, Cysteine dioxygenase type 1, Elongin-B, ...
Authors:Shu, W, Ma, X, Tutter, A, Buckley, D, Golosov, A, Michaud, G.
Deposit date:2024-01-11
Release date:2024-03-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A small molecule VHL molecular glue degrader for cysteine dioxygenase 1
To Be Published
8VL9
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BU of 8vl9 by Molmil
Crystal structure of EloBC-VHL-CDO1 complex bound to compound 8 molecular glue
Descriptor: CITRIC ACID, Cysteine dioxygenase type 1, Elongin-B, ...
Authors:Shu, W, Ma, X, Tutter, A, Buckley, D, Golosov, A, Michaud, G.
Deposit date:2024-01-11
Release date:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A small molecule VHL molecular glue degrader for cysteine dioxygenase 1
To Be Published
8RON
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BU of 8ron by Molmil
Crystal structure of human FAD synthase, isoform 2
Descriptor: Isoform 2 of FAD synthase
Authors:Leo, G, Capaldi, S.
Deposit date:2024-01-11
Release date:2024-04-10
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural insights into the bifunctional enzyme human FAD synthase.
Structure, 2024
8ROM
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BU of 8rom by Molmil
Crystal structure of human FAD synthase PAPS domain in complex with FAD
Descriptor: FAD synthase, FLAVIN-ADENINE DINUCLEOTIDE, PHOSPHATE ION
Authors:Leo, G, Capaldi, S.
Deposit date:2024-01-11
Release date:2024-04-10
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural insights into the bifunctional enzyme human FAD synthase.
Structure, 2024
8RNH
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BU of 8rnh by Molmil
Crystal structure of HLA B*18:01 in complex with EEIEITTHF, an 9-mer epitope from Influenza A
Descriptor: 1,2-ETHANEDIOL, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ...
Authors:Murdolo, L.D, Maddumaage, J, Gras, S.
Deposit date:2024-01-10
Release date:2024-05-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of HLA B*18:01 in complex with EEIEITTHF, an 9-mer epitope from Influenza A
To Be Published
8VKQ
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BU of 8vkq by Molmil
CW Flagellar Switch Complex - FliF, FliG, FliM, and FliN forming the C-ring from Salmonella
Descriptor: Flagellar M-ring protein, Flagellar motor switch protein FliG, Flagellar motor switch protein FliM, ...
Authors:Singh, P.K, Iverson, T.M.
Deposit date:2024-01-09
Release date:2024-02-28
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural basis for rotation and directional switching by the combined MS- and C-rings of bacterial flagella.
To Be Published
8VKR
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BU of 8vkr by Molmil
CW Flagellar Switch Complex with extra density - FliF, FliG, FliM, and FliN forming the C-ring from Salmonella
Descriptor: Flagellar M-ring protein, Flagellar motor switch protein FliG, Flagellar motor switch protein FliM, ...
Authors:Singh, P.K, Iverson, T.M.
Deposit date:2024-01-09
Release date:2024-02-28
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Structural basis for rotation and directional switching by the combined MS- and C-rings of bacterial flagella.
To Be Published
8VKU
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BU of 8vku by Molmil
Structure of VCP in complex with an ATPase activator (D2 domains only, hexameric form)
Descriptor: (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, Transitional endoplasmic reticulum ATPase
Authors:Jones, N.H, Urnivicius, L, Kapoor, T.M.
Deposit date:2024-01-09
Release date:2024-06-19
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry.
Proc.Natl.Acad.Sci.USA, 121, 2024
8XRY
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BU of 8xry by Molmil
Cryo-EM structure of OSCA3.1-1.1ver(Y367N-G454S-Y458I)-open/open state
Descriptor: CSC1-like protein ERD4
Authors:Zhang, Y, Han, Y.
Deposit date:2024-01-08
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.84 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
8XS0
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BU of 8xs0 by Molmil
Cryo-EM structure of OSCA3.1-1.1ver(Y367N-G454S-Y458I)-open/'desensitized' state
Descriptor: CSC1-like protein ERD4
Authors:Zhang, Y, Han, Y.
Deposit date:2024-01-08
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.89 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024

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PDB entries from 2024-06-26

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