8RTZ
The structure of E. coli penicillin binding protein 3 (PBP3) in complex with a bicyclic peptide inhibitor
This is a non-PDB format compatible entry.
Summary for 8RTZ
Entry DOI | 10.2210/pdb8rtz/pdb |
Descriptor | Peptidoglycan D,D-transpeptidase FtsI, Bicyclic peptide inhibitor, 1,1',1''-(1,3,5-triazinane-1,3,5-triyl)tripropan-1-one, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, pbp3 (penicillin binding protein 3), bicyclic peptide, transpeptidase, peptidoglycan, hydrolase |
Biological source | Escherichia coli More |
Total number of polymer chains | 2 |
Total formula weight | 38881.50 |
Authors | Newman, H.,Rowland, C.E.,Dods, R.,Lewis, N.,Stanway, S.J.,Bellini, D.,Beswick, P. (deposition date: 2024-01-29, release date: 2024-04-03) |
Primary citation | Rowland, C.E.,Newman, H.,Martin, T.T.,Dods, R.,Bournakas, N.,Wagstaff, J.M.,Lewis, N.,Stanway, S.J.,Blamforth, M.,Kessler, C.,van Rietschoten, K.,Bellini, D.,Roper, D.I.,Lloyd, A.J.,Dowson, C.G.,Skynner, M.J.,Beswick, P.,Dawson, M. Discovery and chemical optimisation of a Potent, Bi-cyclic (Bicycle) Antimicrobial Inhibitor of Escherichia coli PBP3 To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.52 Å) |
Structure validation
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