8RTZ

The structure of E. coli penicillin binding protein 3 (PBP3) in complex with a bicyclic peptide inhibitor

This is a non-PDB format compatible entry.

Summary for 8RTZ

• Entry DOI: 10.2210/pdb8rtz/pdb
• Descriptor: Peptidoglycan D,D-transpeptidase FtsI, Bicyclic peptide inhibitor, 1,1',1''-(1,3,5-triazinane-1,3,5-triyl)tripropan-1-one, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, pbp3 (penicillin binding protein 3), bicyclic peptide, transpeptidase, peptidoglycan, hydrolase
• Biological source: Escherichia coli; More
• Total number of polymer chains: 2
• Total formula weight: 38881.50

Authors

Newman, H.,Rowland, C.E.,Dods, R.,Lewis, N.,Stanway, S.J.,Bellini, D.,Beswick, P. (deposition date: 2024-01-29, release date: 2024-04-03)

• Primary citation: Rowland, C.E.,Newman, H.,Martin, T.T.,Dods, R.,Bournakas, N.,Wagstaff, J.M.,Lewis, N.,Stanway, S.J.,Blamforth, M.,Kessler, C.,van Rietschoten, K.,Bellini, D.,Roper, D.I.,Lloyd, A.J.,Dowson, C.G.,Skynner, M.J.,Beswick, P.,Dawson, M.; Discovery and chemical optimisation of a Potent, Bi-cyclic (Bicycle) Antimicrobial Inhibitor of Escherichia coli PBP3; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.52 Å)