4OFI
 
 | | Crystal Structure of Duf (Kirre) D1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Kin of irre, isoform A, ... | | Authors: | Ozkan, E, Garcia, K.C. | | Deposit date: | 2014-01-14 | | Release date: | 2014-02-19 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Extracellular Architecture of the SYG-1/SYG-2 Adhesion Complex Instructs Synaptogenesis.
Cell(Cambridge,Mass.), 156, 2014
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4ODX
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4QXW
 | | Crystal structure of the human CEACAM1 membrane distal amino terminal (N)-domain | | Descriptor: | Carcinoembryonic antigen-related cell adhesion molecule 1, MALONIC ACID, octyl beta-D-glucopyranoside | | Authors: | Huang, Y.H, Gandhi, A.K, Russell, A, Kondo, Y, Chen, Q, Petsko, G.A, Blumberg, R.S. | | Deposit date: | 2014-07-22 | | Release date: | 2014-11-12 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Nature, 517, 2015
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4RWH
 | | Crystal structure of T cell costimulatory ligand B7-1 (CD80) | | Descriptor: | T-lymphocyte activation antigen CD80 | | Authors: | Fedorov, A.A, Fedorov, E.V, Samanta, D, Hillerich, B, Seidel, R.D, Almo, S.C. | | Deposit date: | 2014-12-04 | | Release date: | 2014-12-17 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.802 Å) | | Cite: | Crystal structure of T cell costimulatory ligand B7-1 (CD80)
To be Published
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5UD7
 | | Crystal Structure of Wild-Type Ig-like Domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, IODIDE ION, SULFATE ION, ... | | Authors: | Sudom, A, Min, X, Wang, Z. | | Deposit date: | 2016-12-23 | | Release date: | 2018-04-04 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.20002246 Å) | | Cite: | Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
J. Biol. Chem., 293, 2018
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5TRU
 | | Structure of the first-in-class checkpoint inhibitor Ipilimumab bound to human CTLA-4 | | Descriptor: | Cytotoxic T-lymphocyte protein 4, Ipilimumab Fab heavy chain, Ipilimumab Fab light chain | | Authors: | Ramagopal, U.A, Liu, W, Garrett-Thomson, S.C, Yan, Q, Srinivasan, M, Wong, S.C, Bell, A, Mankikar, S, Rangan, V.S, Deshpande, S, Bonanno, J.B, Korman, A.J, Almo, S.C. | | Deposit date: | 2016-10-27 | | Release date: | 2017-05-10 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5V52
 | | Structure of TIGIT bound to nectin-2 (CD112) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Nectin-2, ... | | Authors: | Deuss, F.A, Gully, B.S, Rossjohn, J, Berry, R. | | Deposit date: | 2017-03-13 | | Release date: | 2017-05-24 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Recognition of nectin-2 by the natural killer cell receptor T cell immunoglobulin and ITIM domain (TIGIT).
J. Biol. Chem., 292, 2017
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5UD8
 | | Crystal Structure of Mutant Ig-like Domain | | Descriptor: | Triggering receptor expressed on myeloid cells 2 | | Authors: | Sudom, A, Min, X, Wang, Z. | | Deposit date: | 2016-12-23 | | Release date: | 2018-04-04 | | Last modified: | 2019-04-17 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
J. Biol. Chem., 293, 2018
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5WT9
 | | Complex structure of PD-1 and nivolumab-Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of Nivolumab, Light Chain of Nivolumab, ... | | Authors: | Tan, S, Zhang, H, Chai, Y, Song, H, Tong, Z, Wang, Q, Qi, J, Wong, G, Zhu, X, Liu, W.J, Gao, S, Wang, Z, Shi, Y, Yang, F, Gao, G.F, Yan, J. | | Deposit date: | 2016-12-10 | | Release date: | 2017-02-15 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.401 Å) | | Cite: | An unexpected N-terminal loop in PD-1 dominates binding by nivolumab.
Nat Commun, 8, 2017
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2LVE
 | | RECOMBINANT LEN | | Descriptor: | RLEN | | Authors: | Schiffer, M, Pokkuluri, P.R. | | Deposit date: | 1998-05-13 | | Release date: | 1999-05-18 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | A domain flip as a result of a single amino-acid substitution.
Structure, 6, 1998
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2MCP
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2N7A
 | | Solution structure of the human Siglec-8 lectin domain | | Descriptor: | Sialic acid-binding Ig-like lectin 8 | | Authors: | Proepster, J.M, Yang, F, Rabbani, S, Ernst, B, Allain, F.H.-T, Schubert, M. | | Deposit date: | 2015-09-07 | | Release date: | 2016-07-06 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8.
Proc.Natl.Acad.Sci.USA, 113, 2016
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2OCW
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2NMS
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2OR7
 | | Tim-2 | | Descriptor: | ACETATE ION, T-cell immunoglobulin and mucin domain-containing protein 2 | | Authors: | Santiago, C, Ballesteros, A, Kaplan, G.G, Casasnovas, J.M. | | Deposit date: | 2007-02-02 | | Release date: | 2007-04-03 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structures of T Cell Immunoglobulin Mucin Receptors 1 and 2 Reveal Mechanisms for Regulation of Immune Responses by the TIM Receptor Family.
Immunity, 26, 2007
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2P1Y
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2OR8
 | | Tim-1 | | Descriptor: | ACETATE ION, Hepatitis A virus cellular receptor 1 homolog | | Authors: | Santiago, C, Ballesteros, A, Kaplan, G.G, Casasnovas, J.M. | | Deposit date: | 2007-02-02 | | Release date: | 2007-04-03 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structures of T Cell Immunoglobulin Mucin Receptors 1 and 2 Reveal Mechanisms for Regulation of Immune Responses by the TIM Receptor Family.
Immunity, 26, 2007
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2Q20
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2OTU
 | | Crystal structure of Fv polyglutamine complex | | Descriptor: | Fv heavy chain variable domain, Fv light chain variable domain, peptide antigen | | Authors: | Li, P. | | Deposit date: | 2007-02-09 | | Release date: | 2007-04-24 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Implications of the structure of a poly-Gln/anti-poly-Gln complex for disease progression and therapy
To be Published
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2OYP
 | | T Cell Immunoglobulin Mucin-3 Crystal Structure Revealed a Galectin-9-independent Binding Surface | | Descriptor: | Hepatitis A virus cellular receptor 2, SULFATE ION | | Authors: | Cao, E, Ramagopal, U.A, Fedorov, A.A, Fedorov, E.V, Nathenson, S.G, Almo, S.C. | | Deposit date: | 2007-02-22 | | Release date: | 2007-04-10 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.952 Å) | | Cite: | T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface
Immunity, 26, 2007
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2N4I
 | | The solution structure of Skint-1, a critical determinant of dendritic epidermal gamma-delta T cell selection | | Descriptor: | Selection and upkeep of intraepithelial T-cells protein 1 | | Authors: | Salim, M, Knowles, T.J, Hart, R, Mohammed, F, Woodward, M.J, Willcox, C.R, Overduin, M, Hayday, A.C, Willcox, B.E. | | Deposit date: | 2015-06-18 | | Release date: | 2016-03-02 | | Last modified: | 2016-05-11 | | Method: | SOLUTION NMR | | Cite: | Characterization of a Putative Receptor Binding Surface on Skint-1, a Critical Determinant of Dendritic Epidermal T Cell Selection.
J.Biol.Chem., 291, 2016
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2PTV
 | | Structure of NK cell receptor ligand CD48 | | Descriptor: | CD48 antigen | | Authors: | Deng, L, Velikovsky, C.A, Mariuzza, R.A. | | Deposit date: | 2007-05-08 | | Release date: | 2007-11-20 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family.
Immunity, 27, 2007
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2Q1E
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2Q87
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2N7B
 | | Solution structure of the human Siglec-8 lectin domain in complex with 6'sulfo sialyl Lewisx | | Descriptor: | 3-aminopropan-1-ol, N-acetyl-alpha-neuraminic acid-(2-3)-6-O-sulfo-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose, Sialic acid-binding Ig-like lectin 8 | | Authors: | Proepster, J.M, Yang, F, Rabbani, S, Ernst, B, Allain, F.H.-T, Schubert, M. | | Deposit date: | 2015-09-07 | | Release date: | 2016-07-06 | | Last modified: | 2020-07-29 | | Method: | SOLUTION NMR | | Cite: | Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8.
Proc.Natl.Acad.Sci.USA, 113, 2016
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