5UD8

Crystal Structure of Mutant Ig-like Domain

Summary for 5UD8

• Entry DOI: 10.2210/pdb5ud8/pdb
• Related: 5UD7
• Descriptor: Triggering receptor expressed on myeloid cells 2 (2 entities in total)
• Functional Keywords: ig-like domain, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 25060.42

Authors

Sudom, A.,Min, X.,Wang, Z. (deposition date: 2016-12-23, release date: 2018-04-04, Last modification date: 2019-04-17)

• Primary citation: Sudom, A.,Talreja, S.,Danao, J.,Bragg, E.,Kegel, R.,Min, X.,Richardson, J.,Zhang, Z.,Sharkov, N.,Marcora, E.,Thibault, S.,Bradley, J.,Wood, S.,Lim, A.C.,Chen, H.,Wang, S.,Foltz, I.N.,Sambashivan, S.,Wang, Z.; Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.; J. Biol. Chem., 293:12634-12646, 2018; PubMed: 29794134; DOI: 10.1074/jbc.RA118.002352

Experimental method

X-RAY DIFFRACTION (1.8 Å)