5UD7

Crystal Structure of Wild-Type Ig-like Domain

Summary for 5UD7

• Entry DOI: 10.2210/pdb5ud7/pdb
• Descriptor: Triggering receptor expressed on myeloid cells 2, 2-acetamido-2-deoxy-beta-D-glucopyranose, IODIDE ION, ... (5 entities in total)
• Functional Keywords: ig-like domain, receptor, lipid binding, immunoregulatory, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 116887.36

Authors

Sudom, A.,Min, X.,Wang, Z. (deposition date: 2016-12-23, release date: 2018-04-04, Last modification date: 2023-10-04)

• Primary citation: Sudom, A.,Talreja, S.,Danao, J.,Bragg, E.,Kegel, R.,Min, X.,Richardson, J.,Zhang, Z.,Sharkov, N.,Marcora, E.,Thibault, S.,Bradley, J.,Wood, S.,Lim, A.C.,Chen, H.,Wang, S.,Foltz, I.N.,Sambashivan, S.,Wang, Z.; Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.; J. Biol. Chem., 293:12634-12646, 2018; PubMed: 29794134; DOI: 10.1074/jbc.RA118.002352

Experimental method

X-RAY DIFFRACTION (2.20002253654 Å)