3NMW
 
 | | Crystal structure of armadillo repeats domain of APC | | Descriptor: | APC variant protein, SULFATE ION | | Authors: | Zhang, Z, Chen, L, Gao, L, Lin, K, Wu, G. | | Deposit date: | 2010-06-22 | | Release date: | 2011-07-06 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural basis for the recognition of Asef by adenomatous polyposis coli.
Cell Res., 22, 2012
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1VJ6
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2RQU
 | | Solution structure of the complex between the DDEF1 SH3 domain and the APC SAMP1 motif | | Descriptor: | 19-mer from Adenomatous polyposis coli protein, DDEF1_SH3 | | Authors: | Kaieda, S, Matsui, C, Mimori-Kiyosue, Y, Ikegami, T. | | Deposit date: | 2009-12-14 | | Release date: | 2010-07-07 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structural basis of the recognition of the SAMP motif of adenomatous polyposis coli by the Src-homology 3 domain.
Biochemistry, 49, 2010
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4G69
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5Z8H
 | | APC with an inhibitor | | Descriptor: | Adenomatous polyposis coli protein, GLYCEROL, Peptide inhibitor | | Authors: | Zhang, J, Yang, X.Y, Song, K. | | Deposit date: | 2018-01-31 | | Release date: | 2019-02-06 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | APC with an inhibitor
To Be Published
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7XTY
 | | Crystal Structure of the second PDZ domain from human PTPN13 in complex with APC peptide | | Descriptor: | APC-peptide, Tyrosine-protein phosphatase non-receptor type 13 | | Authors: | Jing, L.Q, Sun, X.N, Ma, W.H, Zhou, W.J, Wu, D.L. | | Deposit date: | 2022-05-18 | | Release date: | 2023-05-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Targeting PTPN13 with 11 amino acid peptides of C-terminal APC prevents immune evasion of colorectal cancer
to be published
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3AU3
 | | Crystal structure of armadillo repeat domain of APC | | Descriptor: | Adenomatous polyposis coli protein | | Authors: | Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2011-01-28 | | Release date: | 2011-11-02 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of sam68
Structure, 19, 2011
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8X2Q
 | | The Crystal Structure of APC from Biortus. | | Descriptor: | 1,2-ETHANEDIOL, Adenomatous polyposis coli protein | | Authors: | Wang, F, Cheng, W, Lv, Z, Ju, C, Bao, C. | | Deposit date: | 2023-11-10 | | Release date: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The Crystal Structure of APC from Biortus.
To Be Published
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8GSJ
 | | APC-Asef tripeptide inhibitor | | Descriptor: | (1R,2S)-2-phenylcyclopropanamine, 2-methylsulfanylpyrimidine-4-carbaldehyde, Adenomatous polyposis coli protein, ... | | Authors: | Zhang, J, Wang, X.F, Song, K. | | Deposit date: | 2022-09-06 | | Release date: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | APC-Asef tripeptide inhibitor
To Be Published
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5IZ6
 | | Protein-protein interaction | | Descriptor: | Adenomatous polyposis coli protein, DI(HYDROXYETHYL)ETHER, PHQ-ALA-GLY-GLU-ALA-LEU-TYR-GLU-NH2, ... | | Authors: | Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. | | Deposit date: | 2016-03-25 | | Release date: | 2017-07-05 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13, 2017
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4YK6
 | | Crystal structure of APC-ARM in complexed with Amer1-A4 | | Descriptor: | APC membrane recruitment protein 1, Adenomatous polyposis coli protein | | Authors: | Zhang, Z, Xiao, Y, Wu, G. | | Deposit date: | 2015-03-04 | | Release date: | 2016-03-09 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners
Cell Discov, 1, 2015
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7F6M
 | | Crystal structure of APC complexed with a peptide inhibitor MAI-516 | | Descriptor: | Adenomatous polyposis coli protein, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | Authors: | Song, K, Zhang, J. | | Deposit date: | 2021-06-25 | | Release date: | 2022-06-29 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Discovery of Efficient Adenomatous Polyposis Coli - Rho Guanine Nucleotide Exchange Factor 4 Inhibitors by Employing High Binding Affinity Tracer
To Be Published
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7F7O
 | | APC-Asef FP assay tracer | | Descriptor: | Adenomatous polyposis coli protein, N-[3',6'-bis(oxidanyl)-3-oxidanylidene-spiro[2-benzofuran-1,9'-xanthene]-5-yl]methanethioamide, Tracer 7 | | Authors: | Yang, X, Zhang, J. | | Deposit date: | 2021-06-30 | | Release date: | 2022-07-06 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The tracer of FP assay for screening APC-Asef inhbitors
To Be Published
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5B6G
 | | Protein-protein interaction | | Descriptor: | Adenomatous polyposis coli protein, GLYCEROL, PHQ-ALA-GLY-GLU-ALA-XYC-TYR-GLU, ... | | Authors: | Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. | | Deposit date: | 2016-05-27 | | Release date: | 2017-05-31 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13, 2017
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4YJE
 | | Crystal structure of APC-ARM in complexed with Amer1-A1 | | Descriptor: | APC membrane recruitment protein 1, Adenomatous polyposis coli protein | | Authors: | Zhang, Z, Xiao, Y, Wu, G. | | Deposit date: | 2015-03-03 | | Release date: | 2016-03-09 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners
Cell Discov, 1, 2015
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4YJL
 | | Crystal structure of APC-ARM in complexed with Amer1-A2 | | Descriptor: | 1,2-ETHANEDIOL, APC membrane recruitment protein 1, Adenomatous polyposis coli protein | | Authors: | Zhang, Z, Xiao, Y, Wu, G. | | Deposit date: | 2015-03-03 | | Release date: | 2016-03-09 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners
Cell Discov, 1, 2015
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1DEB
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1M5I
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1JPP
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1EMU
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1T08
 | | Crystal structure of beta-catenin/ICAT helical domain/unphosphorylated APC R3 | | Descriptor: | Adenomatous polyposis coli protein, Beta-catenin, Beta-catenin-interacting protein 1 | | Authors: | Ha, N.-C, Tonozuka, T, Stamos, J.L, Weis, W.I. | | Deposit date: | 2004-04-07 | | Release date: | 2004-10-12 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation
Mol.Cell, 15, 2004
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3NMX
 | | Crystal structure of APC complexed with Asef | | Descriptor: | APC variant protein, Rho guanine nucleotide exchange factor 4 | | Authors: | Zhang, Z, Chen, L, Gao, L, Lin, K, Wu, G. | | Deposit date: | 2010-06-22 | | Release date: | 2011-07-06 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for the recognition of Asef by adenomatous polyposis coli.
Cell Res., 22, 2012
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3NMZ
 | | Crystal structure of APC complexed with Asef | | Descriptor: | APC variant protein, Rho guanine nucleotide exchange factor 4 | | Authors: | Zhang, Z, Chen, L, Gao, L, Lin, K, Wu, G. | | Deposit date: | 2010-06-23 | | Release date: | 2011-07-06 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.01 Å) | | Cite: | Structural basis for the recognition of Asef by adenomatous polyposis coli.
Cell Res., 22, 2012
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5IZ8
 | | Protein-protein interaction | | Descriptor: | ACE-ALA-GLY-GLU-ALA-LEU-ALA-ASP-NH2, Adenomatous polyposis coli protein, TRIETHYLENE GLYCOL | | Authors: | Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. | | Deposit date: | 2016-03-25 | | Release date: | 2017-07-05 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3.06 Å) | | Cite: | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13, 2017
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5IZA
 | | Protein-protein interaction | | Descriptor: | ACE-GLY-GLY-GLU-ALA-LEU-ALA-TRP-NH2, Adenomatous polyposis coli protein | | Authors: | Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. | | Deposit date: | 2016-03-25 | | Release date: | 2017-07-05 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13, 2017
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