2RQU

Solution structure of the complex between the DDEF1 SH3 domain and the APC SAMP1 motif

Summary for 2RQU

• Entry DOI: 10.2210/pdb2rqu/pdb
• Related: 2RQT
• NMR Information: BMRB: 11082
• Descriptor: DDEF1_SH3, 19-mer from Adenomatous polyposis coli protein (2 entities in total)
• Functional Keywords: sh3 domain, gap, samp motif, tumor suppressor, cell junction, disease mutation, phosphoprotein, wnt signaling pathway, signaling protein
• Biological source: Homo sapiens; More
• Cellular location: Cytoplasm (By similarity): Q9ULH1; Cell junction, adherens junction: P25054
• Total number of polymer chains: 2
• Total formula weight: 9117.31

Authors

Kaieda, S.,Matsui, C.,Mimori-Kiyosue, Y.,Ikegami, T. (deposition date: 2009-12-14, release date: 2010-07-07, Last modification date: 2024-05-01)

• Primary citation: Kaieda, S.,Matsui, C.,Mimori-Kiyosue, Y.,Ikegami, T.; Structural basis of the recognition of the SAMP motif of adenomatous polyposis coli by the Src-homology 3 domain.; Biochemistry, 49:5143-5153, 2010; PubMed: 20509626; DOI: 10.1021/bi100563z

Experimental method

SOLUTION NMR