1T08

Crystal structure of beta-catenin/ICAT helical domain/unphosphorylated APC R3

Summary for 1T08
DescriptorBeta-catenin, Beta-catenin-interacting protein 1, Adenomatous polyposis coli protein, ... (4 entities in total)
Functional Keywordsbeta-catenin; wnt signal; apc; 20mer repeat; wnt signaling, cell adhesion-cell cycle complex, cell adhesion/cell cycle
Biological sourceHomo sapiens (human)
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Cellular locationCytoplasm: P35222
Cytoplasm (By similarity): Q9NSA3
Cell junction, adherens junction: P25054
Total number of polymer chains3
Total formula weight63456.42
Authors
Ha, N.-C.,Tonozuka, T.,Stamos, J.L.,Weis, W.I. (deposition date: 2004-04-07, release date: 2004-10-12, Last modification date: 2011-07-13)
Primary citationChoi, H.J.,Ha, N.-C.,Stamos, J.L.,Tonozuka, T.,Weis, W.I.
Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation
Mol.Cell, 15:511-521, 2004
PubMed: 15327768
DOI: 110.1016/j.molcel.2004.08.010
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation
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PDB entries from 2021-06-16