Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 135 results
3KJF
DownloadVisualize
BU of 3kjf by Molmil
Caspase 3 Bound to a covalent inhibitor
Descriptor: (3S)-3-({[(5S,10aS)-2-{(2S)-4-carboxy-2-[(phenylacetyl)amino]butyl}-1,3-dioxo-2,3,5,7,8,9,10,10a-octahydro-1H-[1,2,4]triazolo[1,2-a]cinnolin-5-yl]carbonyl}amino)-4-oxopentanoic acid, Caspase-3
Authors:Kamtekar, S, Watt, W, Finzel, B.C, Harris, M.S, Blinn, J, Wang, Z, Tomasselli, A.G.
Deposit date:2009-11-03
Release date:2010-08-11
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.
Biochim.Biophys.Acta, 1804, 2010
1I3O
DownloadVisualize
BU of 1i3o by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX OF XIAP-BIR2 AND CASPASE 3
Descriptor: BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4, CASPASE 3, ZINC ION
Authors:Riedl, S.J, Renatus, M, Schwarzenbacher, R, Zhou, Q, Sun, C, Fesik, S.W, Liddington, R.C, Salvesen, G.S.
Deposit date:2001-02-15
Release date:2001-03-21
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for the inhibition of caspase-3 by XIAP.
Cell(Cambridge,Mass.), 104, 2001
4DCP
DownloadVisualize
BU of 4dcp by Molmil
Crystal Structure of caspase 3, L168F mutant
Descriptor: Caspase Inhibitor AC-DEVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17
Authors:Chung, S.J, Kang, H.J, Kim, S.J.
Deposit date:2012-01-18
Release date:2012-12-12
Last modified:2025-03-26
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7
Biosci.Rep., 32, 2012
6X8I
DownloadVisualize
BU of 6x8i by Molmil
Caspase-3 in complex with ketomethylene inhibitor reveals tetrahedral adduct
Descriptor: Caspase-3, ketomethylene inhibitor
Authors:Solania, A, Xu, J.H, Wolan, D.W.
Deposit date:2020-06-01
Release date:2021-06-02
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Caspase-3 in complex with ketomethylene inhibitor reveals tetrahedral adduct
To Be Published
6X8K
DownloadVisualize
BU of 6x8k by Molmil
Caspase-3 in complex with elongated ketomethylene inhibitor
Descriptor: Caspase-3, ketomethylene inhibitor
Authors:Solania, A, Xu, J.H, Wolan, D.W.
Deposit date:2020-06-01
Release date:2021-06-02
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Caspase-3 in complex with elongated ketomethylene inhibitor
To Be Published
4PS0
DownloadVisualize
BU of 4ps0 by Molmil
Caspase-8 specific unnatural amino acid peptides
Descriptor: (BAL)LQ(HYP)(1U8) PEPTIDE, Caspase-3
Authors:Wolan, D.W, Vickers, C.J, Gonzalez-Paez, G.E.
Deposit date:2014-03-06
Release date:2015-01-21
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Selective inhibition of initiator versus executioner caspases using small peptides containing unnatural amino acids.
Acs Chem.Biol., 9, 2014
4PRY
DownloadVisualize
BU of 4pry by Molmil
Caspase-8 specific unnatural amino acid peptides
Descriptor: Ac-LETD-CHO, Caspase-3
Authors:Wolan, D.W, Gonzalez-Paez, G.E, Vickers, C.J.
Deposit date:2014-03-06
Release date:2015-01-21
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Selective inhibition of initiator versus executioner caspases using small peptides containing unnatural amino acids.
Acs Chem.Biol., 9, 2014
1CP3
DownloadVisualize
BU of 1cp3 by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX OF APOPAIN WITH THE TETRAPEPTIDE INHIBITOR ACE-DVAD-FMC
Descriptor: ACETYL-ASP-VAL-ALA-ASP-FLUOROMETHYLKETONE, APOPAIN
Authors:Mittl, P.R.E, Dimarco, S, Gruetter, M.G.
Deposit date:1996-12-12
Release date:1997-12-24
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone.
J.Biol.Chem., 272, 1997
1GFW
DownloadVisualize
BU of 1gfw by Molmil
THE 2.8 ANGSTROM CRYSTAL STRUCTURE OF CASPASE-3 (APOPAIN OR CPP32)IN COMPLEX WITH AN ISATIN SULFONAMIDE INHIBITOR.
Descriptor: 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE, CASPASE-3 (APOPAIN, P10), ...
Authors:Concha, N.O, Janson, C.A.
Deposit date:2000-06-16
Release date:2000-06-23
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality.
J.Biol.Chem., 275, 2000
7XN6
DownloadVisualize
BU of 7xn6 by Molmil
Cryo-EM structure of CopC-CaM-caspase-3 with ADPR-deacylization
Descriptor: Arginine ADP-riboxanase CopC, Calmodulin-1, Caspase-3, ...
Authors:Zhang, K, Peng, T, Tao, X.Y, Tian, M, Li, Y.X, Wang, Z, Ma, S.F, Hu, S.F, Pan, X, Xue, J, Luo, J.W, Wu, Q.L, Fu, Y, Li, S.
Deposit date:2022-04-28
Release date:2022-12-14
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin.
Mol.Cell, 82, 2022
3PCX
DownloadVisualize
BU of 3pcx by Molmil
Caspase-3 E246A, K242A Double Mutant
Descriptor: Caspase-3, Inhibitor Ac-DEVD-CMK
Authors:Walters, J, Swartz, P, Mattos, C, Clark, A.C.
Deposit date:2010-10-22
Release date:2011-02-23
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3.
Arch.Biochem.Biophys., 508, 2011
3PD1
DownloadVisualize
BU of 3pd1 by Molmil
Caspase-3 K242A
Descriptor: Caspase-3, Inhibitor Ac-DEVD-CMK
Authors:Walters, J, Swartz, P, Mattos, C, Clark, A.C.
Deposit date:2010-10-22
Release date:2011-02-23
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3.
Arch.Biochem.Biophys., 508, 2011
3PD0
DownloadVisualize
BU of 3pd0 by Molmil
Caspase-3 E246A
Descriptor: CHLORIDE ION, Caspase-3, INHIBITOR AC-DEVD-CMK
Authors:Walters, J, Swartz, P, Mattos, C, Clark, A.C.
Deposit date:2010-10-22
Release date:2011-02-16
Last modified:2024-11-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3.
Arch.Biochem.Biophys., 508, 2011
7USQ
DownloadVisualize
BU of 7usq by Molmil
Crystal Structure of Caspase-3 with Peptide Inhibitor AcDVPD-CHO
Descriptor: Caspase-3 subunit p12, Caspase-3 subunit p17, Peptide Inhibitor AcDVPD-CHO
Authors:Fuller, J.L, Finzel, B.C.
Deposit date:2022-04-25
Release date:2022-06-01
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Characterization of caspase-2 inhibitors based on specific sites of caspase-2-mediated proteolysis.
Arch Pharm, 355, 2022
7USO
DownloadVisualize
BU of 7uso by Molmil
Crystal Structure of Caspase-3 with Peptide Inhibitor AcITVKD-CHO
Descriptor: Caspase-3 subunit p12, Caspase-3 subunit p17, Peptide Inhibitor AcITVKD-CHO
Authors:Fuller, J.L, Finzel, B.C.
Deposit date:2022-04-25
Release date:2022-06-01
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Characterization of caspase-2 inhibitors based on specific sites of caspase-2-mediated proteolysis.
Arch Pharm, 355, 2022
7USP
DownloadVisualize
BU of 7usp by Molmil
Crystal Structure of Caspase-3 with Peptide Inhibitor AcITV(Orn)D-CHO
Descriptor: Caspase-3 subunit p12, Caspase-3 subunit p17, Peptide Inhibitor AcITV(Orn)D-CHO
Authors:Fuller, J.L, Finzel, B.C.
Deposit date:2022-04-25
Release date:2022-06-01
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Characterization of caspase-2 inhibitors based on specific sites of caspase-2-mediated proteolysis.
Arch Pharm, 355, 2022
7XN4
DownloadVisualize
BU of 7xn4 by Molmil
Cryo-EM structure of CopC-CaM-caspase-3 with NAD+
Descriptor: Arginine ADP-riboxanase CopC, Calmodulin-1, Caspase-3, ...
Authors:Zhang, K, Peng, T, Tao, X.Y, Tian, M, Li, Y.X, Wang, Z, Ma, S.F, Hu, S.F, Pan, X, Xue, J, Luo, J.W, Wu, Q.L, Fu, Y, Li, S.
Deposit date:2022-04-28
Release date:2022-12-14
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin.
Mol.Cell, 82, 2022
7XN5
DownloadVisualize
BU of 7xn5 by Molmil
Cryo-EM structure of CopC-CaM-caspase-3 with ADPR
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, Arginine ADP-riboxanase CopC, Calmodulin-1, ...
Authors:Zhang, K, Peng, T, Tao, X.Y, Tian, M, Li, Y.X, Wang, Z, Ma, S.F, Hu, S.F, Pan, X, Xue, J, Luo, J.W, Wu, Q.L, Fu, Y, Li, S.
Deposit date:2022-04-28
Release date:2022-12-14
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.18 Å)
Cite:Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin.
Mol.Cell, 82, 2022
6BGS
DownloadVisualize
BU of 6bgs by Molmil
Caspase-3 Mutant - S150Y
Descriptor: Ac-Asp-Glu-Val-Asp-CMK, Caspase-3
Authors:Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C.
Deposit date:2017-10-29
Release date:2018-02-21
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Modifications to a common phosphorylation network provide individualized control in caspases.
J. Biol. Chem., 293, 2018
6CL0
DownloadVisualize
BU of 6cl0 by Molmil
Human caspase-3 in complex with Ac-ATS009-KE
Descriptor: ACE-1MH-ASP-PF5-PHE-1U8, Caspase-3 subunit p12, Caspase-3 subunit p17
Authors:Solania, A.T, Gonzalez-Paez, G.E, Wolan, D.W.
Deposit date:2018-03-01
Release date:2019-03-06
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Selective and Rapid Cell-Permeable Inhibitor of Human Caspase-3.
Acs Chem.Biol., 14, 2019
6CKZ
DownloadVisualize
BU of 6ckz by Molmil
Human caspase-3 in complex with Ac-DW3-KE
Descriptor: ACE-1MH-ASP-B3L-PHE-1U8, Caspase-3 subunit p12, Caspase-3 subunit p17
Authors:Solania, A.T, Gonzalez-Paez, G.E, Wolan, D.W.
Deposit date:2018-03-01
Release date:2019-03-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Selective and Rapid Cell-Permeable Inhibitor of Human Caspase-3.
Acs Chem.Biol., 14, 2019
4JQY
DownloadVisualize
BU of 4jqy by Molmil
Human procaspase-3, crystal form 1
Descriptor: Procaspase-3
Authors:Thomsen, N.D, Wells, J.A.
Deposit date:2013-03-20
Release date:2013-05-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.495 Å)
Cite:Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JJE
DownloadVisualize
BU of 4jje by Molmil
Caspase-3 specific unnatural amino acid peptides
Descriptor: Caspase inhibitor, Caspase-3
Authors:Vickers, C.J, Gonzalez-Paez, G.E, Wolan, D.W.
Deposit date:2013-03-07
Release date:2013-06-12
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.481 Å)
Cite:Selective Detection of Caspase-3 versus Caspase-7 Using Activity-Based Probes with Key Unnatural Amino Acids.
Acs Chem.Biol., 8, 2013
4JQZ
DownloadVisualize
BU of 4jqz by Molmil
Human procaspase-3, crystal form 2
Descriptor: Procaspase-3
Authors:Thomsen, N.D, Wells, J.A.
Deposit date:2013-03-20
Release date:2013-05-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.889 Å)
Cite:Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JR0
DownloadVisualize
BU of 4jr0 by Molmil
Human procaspase-3 bound to Ac-DEVD-CMK
Descriptor: Ac-DEVD-CMK, CHLORIDE ION, Procaspase-3
Authors:Thomsen, N.D, Wells, J.A.
Deposit date:2013-03-20
Release date:2013-05-08
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.796 Å)
Cite:Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation.
Proc.Natl.Acad.Sci.USA, 110, 2013

235666

PDB entries from 2025-05-07

PDB statisticsPDBj update infoContact PDBjnumon