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3KJF

Caspase 3 Bound to a covalent inhibitor

Summary for 3KJF
Entry DOI10.2210/pdb3kjf/pdb
Related3KJN 3KJQ
DescriptorCaspase-3, (3S)-3-({[(5S,10aS)-2-{(2S)-4-carboxy-2-[(phenylacetyl)amino]butyl}-1,3-dioxo-2,3,5,7,8,9,10,10a-octahydro-1H-[1,2,4]triazolo[1,2-a]cinnolin-5-yl]carbonyl}amino)-4-oxopentanoic acid, ... (4 entities in total)
Functional Keywordscaspase 3, apoptosis, kinetics, peptidomimetic inhibitor, urazole, phosphoprotein, protease, s-nitrosylation, thiol protease, zymogen, hydrolase
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm: P42574 P42574
Total number of polymer chains2
Total formula weight30101.12
Authors
Kamtekar, S.,Watt, W.,Finzel, B.C.,Harris, M.S.,Blinn, J.,Wang, Z.,Tomasselli, A.G. (deposition date: 2009-11-03, release date: 2010-08-11, Last modification date: 2011-07-13)
Primary citationWang, Z.,Watt, W.,Brooks, N.A.,Harris, M.S.,Urban, J.,Boatman, D.,McMillan, M.,Kahn, M.,Heinrikson, R.L.,Finzel, B.C.,Wittwer, A.J.,Blinn, J.,Kamtekar, S.,Tomasselli, A.G.
Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.
Biochim.Biophys.Acta, 1804:1817-1831, 2010
Cited by
PubMed: 20580860
DOI: 10.1016/j.bbapap.2010.05.007
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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