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PDB: 334 results

8ONV
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BU of 8onv by Molmil
KRAS-G13D in complex with BI-2493
Descriptor: (7~{S})-2'-azanyl-3-[2-[(2~{S})-2-methylpiperazin-1-yl]pyrimidin-4-yl]spiro[5,6-dihydro-4~{H}-1,2-benzoxazole-7,4'-6,7-dihydro-5~{H}-1-benzothiophene]-3'-carbonitrile, 1,2-ETHANEDIOL, GTPase KRas, ...
Authors:Boettcher, J, Herdeis, L.
Deposit date:2023-04-04
Release date:2023-06-07
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.01 Å)
Cite:Pan-KRAS inhibitor disables oncogenic signalling and tumour growth.
Nature, 619, 2023
6P0Z
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BU of 6p0z by Molmil
Crystal structure of N-acetylated KRAS (2-169) bound to GDP and Mg
Descriptor: ACETYL GROUP, DI(HYDROXYETHYL)ETHER, GTPase KRas, ...
Authors:Dharmaiah, S, Tran, T.H, Yan, W, Simanshu, D.K.
Deposit date:2019-05-17
Release date:2019-07-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.011 Å)
Cite:Structures of N-terminally processed KRAS provide insight into the role of N-acetylation.
Sci Rep, 9, 2019
8AZZ
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BU of 8azz by Molmil
KRAS-G12V in complex with BI-2865
Descriptor: (4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile, 1,2-ETHANEDIOL, GTPase KRas, ...
Authors:Boettcher, J, Herdeis, L.
Deposit date:2022-09-06
Release date:2023-06-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.02 Å)
Cite:Pan-KRAS inhibitor disables oncogenic signalling and tumour growth.
Nature, 619, 2023
8AZX
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BU of 8azx by Molmil
KRAS-G12C in complex with BI-2865
Descriptor: (4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile, 1,2-ETHANEDIOL, GTPase KRas, ...
Authors:Boettcher, J, Herdeis, L.
Deposit date:2022-09-06
Release date:2023-06-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:Pan-KRAS inhibitor disables oncogenic signalling and tumour growth.
Nature, 619, 2023
8B00
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BU of 8b00 by Molmil
KRAS-G13D in complex with BI-2865
Descriptor: (4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile, 1,2-ETHANEDIOL, GTPase KRas, ...
Authors:Boettcher, J, Herdeis, L.
Deposit date:2022-09-06
Release date:2023-06-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:Pan-KRAS inhibitor disables oncogenic signalling and tumour growth.
Nature, 619, 2023
4QL3
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BU of 4ql3 by Molmil
Crystal Structure of a GDP-bound G12R Oncogenic Mutant of Human GTPase KRas
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D.
Deposit date:2014-06-10
Release date:2015-06-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.041 Å)
Cite:Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
Mol Cancer Res., 13, 2015
8AZV
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BU of 8azv by Molmil
KRAS in complex with BI-2865
Descriptor: (4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile, 1,2-ETHANEDIOL, GTPase KRas, ...
Authors:Boettcher, J, Herdeis, L.
Deposit date:2022-09-06
Release date:2023-06-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Pan-KRAS inhibitor disables oncogenic signalling and tumour growth.
Nature, 619, 2023
8AZY
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BU of 8azy by Molmil
KRAS-G12D in complex with BI-2865
Descriptor: (4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile, 1,2-ETHANEDIOL, GTPase KRas, ...
Authors:Boettcher, J, Herdeis, L.
Deposit date:2022-09-06
Release date:2023-06-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Pan-KRAS inhibitor disables oncogenic signalling and tumour growth.
Nature, 619, 2023
8B78
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BU of 8b78 by Molmil
KRasG12C ligand complex
Descriptor: 1-[(4~{a}~{R})-8-(2-chloranyl-6-oxidanyl-phenyl)-7-fluoranyl-9-prop-1-ynyl-1,2,4,4~{a},5,11-hexahydropyrazino[2,1-c][1,4]benzoxazepin-3-yl]propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Phillips, C, Breed, J.
Deposit date:2022-09-29
Release date:2023-07-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS G12C with Demonstrable CNS Penetration.
J.Med.Chem., 66, 2023
8AFB
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BU of 8afb by Molmil
CRYSTAL STRUCTURE OF KRAS-G12C IN COMPLEX WITH COMPOUND 23 (BI-0474)
Descriptor: (4~{S})-2-azanyl-4-[3-[6-[(2~{S})-2,4-dimethylpiperazin-1-yl]-4-(4-prop-2-enoylpiperazin-1-yl)pyridin-2-yl]-1,2,4-oxadiazol-5-yl]-4-methyl-6,7-dihydro-5~{H}-1-benzothiophene-3-carbonitrile, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Boettcher, J, Kessler, D.
Deposit date:2022-07-16
Release date:2022-11-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor.
J.Med.Chem., 65, 2022
8FMI
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BU of 8fmi by Molmil
Crystal structure of human KRAS at 1.12 A
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION
Authors:Brenner, R, Landgraf, A, Gonzalez-Gutierrez, G, Bum-Erdene, K, Meroueh, S.O.
Deposit date:2022-12-23
Release date:2023-11-29
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Crystal Packing Reveals a Potential Autoinhibited KRAS Dimer Interface and a Strategy for Small-Molecule Inhibition of RAS Signaling.
Biochemistry, 62, 2023
4TQA
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BU of 4tqa by Molmil
Crystal Structure of a GDP-bound G13D Oncogenic Mutant of Human GTPase KRas
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D.
Deposit date:2014-06-10
Release date:2015-06-10
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
Mol Cancer Res., 13, 2015
4LDJ
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BU of 4ldj by Molmil
Crystal Structure of a GDP-bound G12C Oncogenic Mutant of Human GTPase KRas
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Hunter, J.C, Gurbani, D, Chen, Z, Westover, K.D.
Deposit date:2013-06-24
Release date:2014-06-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C.
Proc.Natl.Acad.Sci.USA, 111, 2014
6TAN
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BU of 6tan by Molmil
X-RAY STRUCTURE OF HUMAN K-RAS G12C IN COMPLEX WITH COVALENT ISOQUINOLINONE INHIBITOR (COMPOUND 17)
Descriptor: 7-(2-fluoranyl-6-oxidanyl-phenyl)-3-[(3~{R})-1-propanoylpyrrolidin-3-yl]-4~{H}-2,6-naphthyridin-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Hillig, R.C, Eis, K, Badock, V.
Deposit date:2019-10-30
Release date:2020-04-08
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRASG12C.
Chemmedchem, 15, 2020
7O70
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BU of 7o70 by Molmil
KRasG12C ligand complex
Descriptor: 1-[(4R,7S)-12-chloro-14-fluoro-13-(2-fluoro-6-hydroxyphenyl)-4-methyl-10-oxa-2,5,16,18-tetrazatetracyclo[9.7.1.0^(2,7).0^(15,19)]nonadeca-1(18),11,13,15(19),16-pentaen-5-en-1-one-yl]prop-2, CALCIUM ION, GTPase KRas, ...
Authors:Phillips, C.
Deposit date:2021-04-12
Release date:2022-04-20
Last modified:2022-05-25
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C .
J.Med.Chem., 65, 2022
8EDY
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BU of 8edy by Molmil
KRAS4b A146T 1-185 bound to GDP
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE
Authors:Betts, L, Rossman, K.L.
Deposit date:2022-09-06
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:KRAS4b A146T 1-185 bound to GDP
To Be Published
8EER
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BU of 8eer by Molmil
KRAS4B A146V 1-185 bound to GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Isoform 4b of the GTPase KRAS
Authors:Betts, L, Rossman, K.L.
Deposit date:2022-09-07
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:KRAS4B A146V 1-185 bound to GDP
To Be Published
7R0N
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BU of 7r0n by Molmil
KRasG12C in complex with GDP and compound 2
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ostermann, N.
Deposit date:2022-02-02
Release date:2022-04-27
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.
Cancer Discov, 12, 2022
8TXH
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BU of 8txh by Molmil
Crystal structure of KRAS G12D in complex with GDP and compound 14
Descriptor: (4P)-2-amino-4-{4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}-6-(trifluoromethyl)quinazolin-7-yl}-7-fluoro-1-benzothiophene-3-carbonitrile, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Chen, P, Irimia, A, Yang, Z.
Deposit date:2023-08-23
Release date:2023-11-08
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure-Based Design and Synthesis of Potent and Selective KRAS G12D Inhibitors.
Acs Med.Chem.Lett., 14, 2023
8EBZ
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BU of 8ebz by Molmil
Crystal Structure of GMPPNP-bound KRAS-G13D mutant at 1.2 Ang resolution
Descriptor: Isoform 2B of GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Chan, A.H, Simanshu, D.K.
Deposit date:2022-08-31
Release date:2023-06-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Reduced dynamic complexity allows structure elucidation of an excited state of KRAS G13D .
Commun Biol, 6, 2023
4Q03
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BU of 4q03 by Molmil
Second-site screening of K-Ras in the presence of covalently attached first-site ligands
Descriptor: 4-bromobenzenethiol, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Sun, Q, Phan, J, Friberg, A, Camper, D.V, Olejniczak, E.T, Fesik, S.W.
Deposit date:2014-03-31
Release date:2014-09-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.201 Å)
Cite:A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand.
J.Biomol.Nmr, 60, 2014
4OBE
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BU of 4obe by Molmil
Crystal Structure of GDP-bound Human KRas
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Hunter, J.C, Gurbani, D, Chen, Z, Westover, K.D.
Deposit date:2014-01-07
Release date:2014-06-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C.
Proc.Natl.Acad.Sci.USA, 111, 2014
6QUW
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BU of 6quw by Molmil
Crystal Structure of KRAS-G12D in Complex with Natural Product-Like Compound 9b
Descriptor: (3~{a}~{R},8~{b}~{S})-2,2,3~{a},8~{b}-tetramethyl-3,4-dihydro-1~{H}-pyrrolo[2,3-b]indole, GTPase KRas, MAGNESIUM ION, ...
Authors:Fischer, G, Kessler, D, Muellauer, B, Wolkerstorfer, B.
Deposit date:2019-02-28
Release date:2019-07-31
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.242 Å)
Cite:KRAS Binders Hidden in Nature.
Chemistry, 25, 2019
5XCO
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BU of 5xco by Molmil
Crystal structure of human K-Ras G12D Mutant in complex with GDP and Cyclic Inhibitory Peptide
Descriptor: 1,2-ETHANEDIOL, ACE-ARG-ARG-ARG-ARG-CYS-PRO-LEU-TYR-ILE-SER-TYR-ASP-PRO-VAL-CYS-ARG-ARG-ARG-ARG-NH2, GTPase KRas, ...
Authors:Sogabe, S, Miwa, M.
Deposit date:2017-03-23
Release date:2017-05-24
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d
ACS Med Chem Lett, 8, 2017
9BFY
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BU of 9bfy by Molmil
Tri-complex of Compound-12, KRAS G12C, and CypA
Descriptor: (3R)-N-[(2S)-1-{[(1M,8R,10R,14S,21M)-22-ethyl-4-hydroxy-21-{2-[(1R)-1-methoxyethyl]pyridin-3-yl}-18,18-dimethyl-9,15-dioxo-16-oxa-10,22,28-triazapentacyclo[18.5.2.1~2,6~.1~10,14~.0~23,27~]nonacosa-1(25),2(29),3,5,20,23,26-heptaen-8-yl]amino}-3-methyl-1-oxobutan-2-yl]-N-methyl-1-propanoylpyrrolidine-3-carboxamide (non-preferred name), CHLORIDE ION, GTPase KRas, ...
Authors:Tomlinson, A.C.A, Saldajeno-Concar, M, Knox, J.E, Yano, J.K.
Deposit date:2024-04-18
Release date:2024-06-12
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers.
Cancer Discov, 14, 2024

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