4QL3
Crystal Structure of a GDP-bound G12R Oncogenic Mutant of Human GTPase KRas
Summary for 4QL3
Entry DOI | 10.2210/pdb4ql3/pdb |
Related | 4LDJ 4OBE 4TQ9 4TQA 4WA7 |
Descriptor | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | small gtpase, signal transduction, gdp binding, gtp binding, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116 |
Total number of polymer chains | 1 |
Total formula weight | 19896.46 |
Authors | Hunter, J.C.,Manandhar, A.,Gurbani, D.,Chen, Z.,Westover, K.D. (deposition date: 2014-06-10, release date: 2015-06-10, Last modification date: 2024-02-28) |
Primary citation | Hunter, J.C.,Manandhar, A.,Carrasco, M.A.,Gurbani, D.,Gondi, S.,Westover, K.D. Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations. Mol Cancer Res., 13:1325-1335, 2015 Cited by PubMed: 26037647DOI: 10.1158/1541-7786.MCR-15-0203 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.041 Å) |
Structure validation
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