Crystal Structure of a GDP-bound G12R Oncogenic Mutant of Human GTPase KRas

Summary for 4QL3

Related4LDJ 4OBE 4TQA 4TQ9 4WA7
DescriptorGTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordssmall gtpase, signal transduction, gdp binding, gtp binding, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationCell membrane ; Lipid-anchor ; Cytoplasmic side  P01116
Total number of polymer chains1
Total molecular weight19896.46
Hunter, J.C.,Manandhar, A.,Gurbani, D.,Chen, Z.,Westover, K.D. (deposition date: 2014-06-10, release date: 2015-06-10, Last modification date: 2015-09-30)
Primary citation
Hunter, J.C.,Manandhar, A.,Carrasco, M.A.,Gurbani, D.,Gondi, S.,Westover, K.D.
Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
Mol Cancer Res., 13:1325-1335, 2015
PubMed: 26037647 (PDB entries with the same primary citation)
DOI: 10.1158/1541-7786.MCR-15-0203
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.15610018.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload