8ONV
KRAS-G13D in complex with BI-2493
Summary for 8ONV
Entry DOI | 10.2210/pdb8onv/pdb |
Related | 8AZR 8AZV 8AZX 8AZY 8AZZ 8B00 |
Descriptor | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | kras, gtpase, inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 20424.00 |
Authors | Boettcher, J.,Herdeis, L. (deposition date: 2023-04-04, release date: 2023-06-07, Last modification date: 2024-06-19) |
Primary citation | Kim, D.,Herdeis, L.,Rudolph, D.,Zhao, Y.,Bottcher, J.,Vides, A.,Ayala-Santos, C.I.,Pourfarjam, Y.,Cuevas-Navarro, A.,Xue, J.Y.,Mantoulidis, A.,Broker, J.,Wunberg, T.,Schaaf, O.,Popow, J.,Wolkerstorfer, B.,Kropatsch, K.G.,Qu, R.,de Stanchina, E.,Sang, B.,Li, C.,McConnell, D.B.,Kraut, N.,Lito, P. Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature, 619:160-166, 2023 Cited by PubMed: 37258666DOI: 10.1038/s41586-023-06123-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.01 Å) |
Structure validation
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