8ONV

KRAS-G13D in complex with BI-2493

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	GTPase KRas	polymer	170	19370.8	1	UniProt (P01116) Pfam (PF00071) In PDB	Homo sapiens (human)	K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
2	A	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	1	Chemie (GDP)
3	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
4	A	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
5	A	(7~{S})-2'-azanyl-3-[2-[(2~{S})-2-methylpiperazin-1-yl]pyrimidin-4-yl]spiro[5,6-dihydro-4~{H}-1,2-benzoxazole-7,4'-6,7-dihydro-5~{H}-1-benzothiophene]-3'-carbonitrile	non-polymer		461.6	1	Chemie (VU6)
6		water	water		18.0	281	Chemie (HOH)

Sequence modifications

A: 1 - 164 (UniProt: P01116)

PDB	External Database	Details
Gly 0	-	expression tag
Asp 13	Gly 13	engineered mutation
Ser 118	Cys 118	engineered mutation
Gly 151	Arg 151	engineered mutation
Asp 153	Glu 153	engineered mutation
Lys 165	-	expression tag
His 166	-	expression tag
Lys 167	-	expression tag
Glu 168	-	expression tag
Lys 169	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	19370.8
Non-Polymers*	Number of molecules	5
	Total formula weight	1053.2
All*	Total formula weight	20424.0

*Water molecules are not included.