8AZV

KRAS in complex with BI-2865

Summary for 8AZV

Entry DOI	10.2210/pdb8azv/pdb
Related	8AZR
Descriptor	GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	inhibitor, complex, gtpase, oncoprotein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	20370.97
Authors	Boettcher, J.,Herdeis, L. (deposition date: 2022-09-06, release date: 2023-06-07, Last modification date: 2024-02-14)
Primary citation	Kim, D.,Herdeis, L.,Rudolph, D.,Zhao, Y.,Bottcher, J.,Vides, A.,Ayala-Santos, C.I.,Pourfarjam, Y.,Cuevas-Navarro, A.,Xue, J.Y.,Mantoulidis, A.,Broker, J.,Wunberg, T.,Schaaf, O.,Popow, J.,Wolkerstorfer, B.,Kropatsch, K.G.,Qu, R.,de Stanchina, E.,Sang, B.,Li, C.,McConnell, D.B.,Kraut, N.,Lito, P. Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature, 619:160-166, 2023 Cited by PubMed: 37258666 DOI: 10.1038/s41586-023-06123-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.05 Å)

Structure validation