8FMI
Crystal structure of human KRAS at 1.12 A
Summary for 8FMI
| Entry DOI | 10.2210/pdb8fmi/pdb |
| Descriptor | Isoform 2B of GTPase KRas, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total) |
| Functional Keywords | cancer, hydrolase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 19780.25 |
| Authors | Brenner, R.,Landgraf, A.,Gonzalez-Gutierrez, G.,Bum-Erdene, K.,Meroueh, S.O. (deposition date: 2022-12-23, release date: 2023-11-29, Last modification date: 2023-12-06) |
| Primary citation | Brenner, R.J.,Landgraf, A.D.,Bum-Erdene, K.,Gonzalez-Gutierrez, G.,Meroueh, S.O. Crystal Packing Reveals a Potential Autoinhibited KRAS Dimer Interface and a Strategy for Small-Molecule Inhibition of RAS Signaling. Biochemistry, 62:3206-3213, 2023 Cited by PubMed: 37938120DOI: 10.1021/acs.biochem.3c00378 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.12 Å) |
Structure validation
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