5XCO
Crystal structure of human K-Ras G12D Mutant in complex with GDP and Cyclic Inhibitory Peptide
Summary for 5XCO
Entry DOI | 10.2210/pdb5xco/pdb |
Descriptor | GTPase KRas, ACE-ARG-ARG-ARG-ARG-CYS-PRO-LEU-TYR-ILE-SER-TYR-ASP-PRO-VAL-CYS-ARG-ARG-ARG-ARG-NH2, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | hydrolase, complex, inhibitor, small gtpase, oncogene, signaling, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116 |
Total number of polymer chains | 2 |
Total formula weight | 22533.28 |
Authors | Sogabe, S.,Miwa, M. (deposition date: 2017-03-23, release date: 2017-05-24, Last modification date: 2023-11-22) |
Primary citation | Sogabe, S.,Kamada, Y.,Miwa, M.,Niida, A.,Sameshima, T.,Kamaura, M.,Yonemori, K.,Sasaki, S.,Sakamoto, J.,Sakamoto, K. Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d ACS Med Chem Lett, 8:732-736, 2017 Cited by PubMed: 28740607DOI: 10.1021/acsmedchemlett.7b00128 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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