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PDB: 26 results

5HOB
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BU of 5hob by Molmil
p73 homo-tetramerization domain mutant I
Descriptor: MAGNESIUM ION, Tumor protein p73
Authors:Coutandin, D, Krojer, T, Salah, E, Mathea, S, Knapp, S, Dotsch, V.
Deposit date:2016-01-19
Release date:2016-10-19
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.220013 Å)
Cite:Structural basis of p63/p73 hetero-tetramerization
To Be Published
5HOC
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BU of 5hoc by Molmil
p73 homo-tetramerization domain mutant II
Descriptor: Tumor protein p73
Authors:Coutandin, D, Krojer, T, Salah, E, Mathea, S, Sumyk, M, Knapp, S, Dotsch, V.
Deposit date:2016-01-19
Release date:2016-10-19
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.36007786 Å)
Cite:Mechanism of TAp73 inhibition by Delta Np63 and structural basis of p63/p73 hetero-tetramerization.
Cell Death Differ., 23, 2016
2WQI
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BU of 2wqi by Molmil
Crystal structure of the human p73 tetramerization domain
Descriptor: TUMOR PROTEIN P73
Authors:Joerger, A.C.
Deposit date:2009-08-21
Release date:2009-10-06
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Evolution of P53, P63, and P73: Implication for Heterotetramer Formation.
Proc.Natl.Acad.Sci.USA, 106, 2009
8P9C
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BU of 8p9c by Molmil
Crystal structure of p63-p73 heterotetramer (tetramerisation domain) in complex with darpin 1810 F11
Descriptor: 1,2-ETHANEDIOL, Darpin 1810 F11, Tumor protein 63, ...
Authors:Chaikuad, A, Strubel, A, Doetsch, V, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2023-06-05
Release date:2023-11-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma.
Cell Death Dis, 14, 2023
2XWC
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BU of 2xwc by Molmil
Crystal structure of the DNA binding domain of human TP73 refined at 1.8 A resolution
Descriptor: GLYCEROL, TRIS(HYDROXYETHYL)AMINOMETHANE, TUMOUR PROTEIN P73, ...
Authors:Canning, P, Zhang, Y, Vollmar, M, Krojer, T, Ugochukwu, E, Muniz, J.R.C, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N.
Deposit date:2010-11-03
Release date:2010-11-17
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structural Basis for Aspp2 Recognition by the Tumor Suppressor P73.
J.Mol.Biol., 423, 2012
2WQJ
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BU of 2wqj by Molmil
Crystal structure of a truncated variant of the human p73 tetramerization domain
Descriptor: TUMOR PROTEIN P73
Authors:Joerger, A.C.
Deposit date:2009-08-21
Release date:2009-10-06
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Evolution of P53, P63, and P73: Implication for Heterotetramer Formation.
Proc.Natl.Acad.Sci.USA, 106, 2009
8P9E
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BU of 8p9e by Molmil
Crystal structure of wild type p63-p73 heterotetramer (tetramerisation domain) in complex with darpin 1810 F11
Descriptor: Darpin 1810 F11, GLYCEROL, Isoform 2 of Tumor protein 63, ...
Authors:Chaikuad, A, Strubel, A, Doetsch, V, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2023-06-05
Release date:2023-11-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma.
Cell Death Dis, 14, 2023
4A63
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BU of 4a63 by Molmil
Crystal structure of the p73-ASPP2 complex at 2.6A resolution
Descriptor: ACETATE ION, APOPTOSIS STIMULATING OF P53 PROTEIN 2, TUMOUR PROTEIN 73, ...
Authors:Canning, P, Sharpe, T, Krojer, T, Savitsky, P, Cooper, C.D.O, Salah, E, Keates, T, Muniz, J, Vollmar, M, von Delft, F, Weigelt, J, Arrowsmith, C, Bountra, C, Edwards, A, Bullock, A.N.
Deposit date:2011-10-31
Release date:2011-12-21
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural Basis for Aspp2 Recognition by the Tumor Suppressor P73.
J.Mol.Biol., 423, 2012
2WTT
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BU of 2wtt by Molmil
Structure of the human p73 tetramerization domain (crystal form II)
Descriptor: TUMOR PROTEIN P73
Authors:Joerger, A.C.
Deposit date:2009-09-21
Release date:2009-10-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Evolution of P53, P63, and P73: Implication for Heterotetramer Formation.
Proc.Natl.Acad.Sci.USA, 106, 2009
1DXS
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BU of 1dxs by Molmil
Crystal structure of the C-terminal sterile alpha motif (SAM) domain of human p73 alpha splice variant
Descriptor: P53-LIKE TRANSCRIPTION FACTOR
Authors:Wang, W.K, Chen, Y.W.
Deposit date:2000-01-15
Release date:2001-01-12
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Structure of the C-Terminal Sterile Alpha-Motif (Sam) Domain of Human P73 Alpha
Acta Crystallogr.,Sect.D, 57, 2001
8P9D
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BU of 8p9d by Molmil
Crystal structure of p63-p73 heterotetramer (tetramerisation domain) in complex with darpin 1810 A2
Descriptor: Darpin 1810 A2, Tumor protein 63, Tumor protein p73
Authors:Chaikuad, A, Strubel, A, Doetsch, V, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2023-06-05
Release date:2023-11-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma.
Cell Death Dis, 14, 2023
5KBD
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BU of 5kbd by Molmil
Structural Studies of Transcription Factor p73 DNA Binding Domain Bound to PA26 20-mer Response Element
Descriptor: DNA (5'-D(P*AP*GP*AP*CP*TP*TP*GP*TP*CP*C)-3'), DNA (5'-D(P*GP*GP*AP*CP*AP*AP*GP*TP*CP*T)-3'), Tumor protein p73, ...
Authors:Nguyen, H.T, Huang, D.
Deposit date:2016-06-03
Release date:2016-08-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Studies of Transcription Factor p73 DNA Binding Domain Bound to PA26 20-mer Response Element
To Be Published
7EZJ
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BU of 7ezj by Molmil
Crystal structure of p73 DNA binding domain complex bound with 1 bp and 2 bp spacer DNA response elements.
Descriptor: 12-mer DNA, Tumor protein p73, ZINC ION
Authors:Koley, T, Roy Chowdhury, S, Kumar, M, Kaur, P, Singh, T.P, Viadiu, H, Ethayathulla, A.S.
Deposit date:2021-06-01
Release date:2022-04-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Deciphering the mechanism of p73 recognition of p53 response elements using the crystal structure of p73-DNA complexes and computational studies.
Int.J.Biol.Macromol., 206, 2022
3VD0
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BU of 3vd0 by Molmil
structure of p73 DNA binding domain tetramer modulates p73 transactivation
Descriptor: DNA (5'-D(*CP*AP*GP*GP*CP*AP*TP*GP*CP*CP*TP*G)-3'), Tumor protein p73, ZINC ION
Authors:Ethayathulla, A.S, Tse, P.W, Nguyen, S, Viadiu, H.
Deposit date:2012-01-04
Release date:2012-04-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure of p73 DNA-binding domain tetramer modulates p73 transactivation.
Proc.Natl.Acad.Sci.USA, 109, 2012
3VD1
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BU of 3vd1 by Molmil
structure of p73 DNA binding domain tetramer modulates p73 transactivation
Descriptor: DNA (5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3'), Tumor protein p73, ZINC ION
Authors:Ethayathulla, A.S, Tse, P.W, Nguyen, S, Viadiu, H.
Deposit date:2012-01-04
Release date:2012-04-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure of p73 DNA-binding domain tetramer modulates p73 transactivation.
Proc.Natl.Acad.Sci.USA, 109, 2012
4G82
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BU of 4g82 by Molmil
Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element
Descriptor: DNA (5'-D(P*GP*AP*AP*CP*AP*TP*GP*TP*TP*C)-3'), Tumor protein p73, ZINC ION
Authors:Ethayathulla, A.S, Viadiu, H.
Deposit date:2012-07-20
Release date:2013-01-16
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element
J.Biol.Chem., 2013
4GUO
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BU of 4guo by Molmil
structure of p73 DNA binding domain complex with 12 bp DNA
Descriptor: DNA (5'-D(*CP*GP*GP*GP*CP*AP*AP*GP*CP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*GP*CP*TP*TP*GP*CP*CP*CP*G)-3'), Tumor protein p73, ...
Authors:Ethayathulla, A.S, Viadiu, H.
Deposit date:2012-08-29
Release date:2013-11-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:structure of p73 DNA binding domain complex with 12 bp DNA
To be Published
4GUQ
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BU of 4guq by Molmil
Structure of mutS139F p73 DNA binding domain complexed with 20BP DNA response element
Descriptor: DNA (5'-D(P*GP*AP*AP*CP*AP*TP*GP*TP*TP*C)-3'), Tumor protein p73, ZINC ION
Authors:Ethayathulla, A.S, Nguyen, H.T, Viadiu, H.
Deposit date:2012-08-29
Release date:2013-08-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code.
Nucleic Acids Res., 41, 2013
3VD2
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BU of 3vd2 by Molmil
structure of p73 DNA binding domain tetramer modulates p73 transactivation
Descriptor: DNA (5'-D(*AP*TP*GP*GP*AP*CP*AP*TP*GP*TP*CP*CP*AP*T)-3'), Tumor protein p73, ZINC ION
Authors:Ethayathulla, A.S, Tse, P.W, Nguyen, S, Viadiu, H.
Deposit date:2012-01-04
Release date:2012-04-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structure of p73 DNA-binding domain tetramer modulates p73 transactivation.
Proc.Natl.Acad.Sci.USA, 109, 2012
4G83
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BU of 4g83 by Molmil
Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element
Descriptor: Tumor protein p73, ZINC ION, dna
Authors:Ethayathulla, A.S, Viadiu, H.
Deposit date:2012-07-20
Release date:2013-01-16
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (4 Å)
Cite:Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element
J.Biol.Chem., 2013
6IJQ
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BU of 6ijq by Molmil
Solution structure of BCL-XL bound to P73-TAD peptide
Descriptor: Bcl-2-like protein 1,Bcl-2-like protein 1, Tumor protein p73
Authors:Yoon, M.-K, Ha, J.-H, Lee, M.-S, Chi, S.-W.
Deposit date:2018-10-11
Release date:2018-11-21
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Cytoplasmic pro-apoptotic function of the tumor suppressor p73 is mediated through a modified mode of recognition of the anti-apoptotic regulator Bcl-XL.
J. Biol. Chem., 293, 2018
6FGS
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BU of 6fgs by Molmil
Solution structure of p300Taz2-p73TA1
Descriptor: Histone acetyltransferase p300,Tumor protein p73, ZINC ION
Authors:Gebel, J, Kazemi, S, Lohr, F, Guntert, P, Dotsch, V.
Deposit date:2018-01-11
Release date:2018-05-30
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain.
Structure, 26, 2018
2NB1
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BU of 2nb1 by Molmil
P63/p73 hetero-tetramerisation domain
Descriptor: Tumor protein 63, Tumor protein p73
Authors:Gebel, J, Buchner, L, Loehr, F.M, Luh, L.M, Coutandin, D, Guentert, P, Doetsch, V.
Deposit date:2016-01-19
Release date:2016-12-07
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Mechanism of TAp73 inhibition by Delta Np63 and structural basis of p63/p73 hetero-tetramerization.
Cell Death Differ., 23, 2016
1COK
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BU of 1cok by Molmil
STRUCTURE OF THE C-TERMINAL DOMAIN OF P73
Descriptor: PROTEIN (SECOND SPLICE VARIANT P73)
Authors:Chi, S.-W, Ayed, A, Arrowsmith, C.H.
Deposit date:1999-05-28
Release date:1999-08-17
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain.
EMBO J., 18, 1999
2KBY
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BU of 2kby by Molmil
The Tetramerization Domain of Human p73
Descriptor: Tumor protein p73
Authors:Coutandin, D, Ikeya, T, Loehr, F, Guntert, P, Ou, H.D, Doetsch, V.
Deposit date:2008-12-12
Release date:2009-09-29
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Conformational stability and activity of p73 require a second helix in the tetramerization domain.
Cell Death Differ., 16, 2009

 

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