PDB: 294 resultsInfo pagesStatus searchChemie searchBIRD

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1TH1	Beta-catenin in complex with a phosphorylated APC 20aa repeat fragment Descriptor: Adenomatous polyposis coli protein, Beta-catenin Authors: Xing, Y, Clements, W.K, Le Trong, I, Hinds, T.R, Stenkamp, R, Kimelman, D, Xu, W. Deposit date: 2004-05-31 Release date: 2004-09-07 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal Structure of a beta-Catenin/APC Complex Reveals a Critical Role for APC Phosphorylation in APC Function. Mol.Cell, 15, 2004
8SUD	JC Polyomavirus LTA NLS bound to importin alpha 2 Descriptor: Importin subunit alpha-1, Large T antigen Authors: Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-05-12 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
7LFC	Structure of importin a3 bound to p50 NLS Descriptor: Importin subunit alpha-3, Nuclear factor NF-kappa-B p105 subunit Authors: Florio, T.J, Lokareddy, R.K, Cingolani, G. Deposit date: 2021-01-16 Release date: 2022-01-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Differential recognition of canonical NF-kappa B dimers by Importin alpha 3. Nat Commun, 13, 2022
7LF4	Structure of importin a3 bound to the p50- and p65-NLSs Descriptor: Importin subunit alpha-3, Nuclear factor NF-kappa-B p105 subunit, Transcription factor p65 Authors: Florio, T.J, Lokareddy, R.K, Cingolani, G. Deposit date: 2021-01-15 Release date: 2022-01-19 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Differential recognition of canonical NF-kappa B dimers by Importin alpha 3. Nat Commun, 13, 2022
7LET	Structure of importin a2 bound to the p50- and p65-NLSs Descriptor: Importin subunit alpha-1, Nuclear factor NF-kappa-B p105 subunit, Transcription factor p65 Authors: Florio, T.J, Lokareddy, R.K, Cingolani, G. Deposit date: 2021-01-15 Release date: 2022-01-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Differential recognition of canonical NF-kappa B dimers by Importin alpha 3. Nat Commun, 13, 2022
7LEU	Structure of importin a2 bound to p65-NLS Descriptor: Importin subunit alpha-1, Transcription factor p65 Authors: Florio, T.J, Lokareddy, R.K, Cingolani, G. Deposit date: 2021-01-15 Release date: 2022-01-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.82 Å) Cite: Differential recognition of canonical NF-kappa B dimers by Importin alpha 3. Nat Commun, 13, 2022
7LEQ	Structure of importin a2 bound to p50 NLS Descriptor: Importin subunit alpha-1, Nuclear factor NF-kappa-B p105 subunit Authors: Florio, T.J, Lokareddy, R.K, Cingolani, G. Deposit date: 2021-01-14 Release date: 2022-01-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Differential recognition of canonical NF-kappa B dimers by Importin alpha 3. Nat Commun, 13, 2022
7M60	Structure of Mouse Importin alpha MLH1-S467A NLS Peptide Complex Descriptor: DNA mismatch repair protein Mlh1 NLS peptide, Importin subunit alpha-1 Authors: De Oliveira, H.C, Da Silva, T.D, Fukuda, C.A, Fontes, M.R.M. Deposit date: 2021-03-25 Release date: 2021-07-07 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha. Biochem.J., 478, 2021
8U36	The crystal structure of the classical binding interface of Importin alpha 2 and a nuclear localisation signal sequence in Frog siadenovirus core protein VII Descriptor: Importin subunit alpha-1, PVII, SODIUM ION Authors: Athukorala, A, Donnelly, C.M, Forwood, J.K, Sarker, S. Deposit date: 2023-09-07 Release date: 2023-11-22 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural and functional characterization of nuclear localization signals of pVII protein of Frog siadenovirus To be published
7N8J	Human importin alpha 1 in complex with Bimax2 peptide Descriptor: BIMAX2, Importin subunit alpha-1 Authors: Donnelly, C.M, Cross, E.M, Tsimbalyuk, S, Forwood, J.K. Deposit date: 2021-06-15 Release date: 2021-06-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Human importin alpha 1:Bimax2 peptide complex To Be Published
8VPU	Crystal structure of mouse Importin alpha in complex with dengue virus 3 NS5 central NLS peptide Descriptor: Importin subunit alpha-1, RNA-directed RNA polymerase NS5 central NLS peptide Authors: Roman, N, Swarbrick, C.M.D, Forwood, J.K. Deposit date: 2024-01-17 Release date: 2024-08-21 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Serotype-Specific Regulation of Dengue Virus NS5 Protein Subcellular Localization. Acs Infect Dis., 10, 2024
8VPR	Crystal structure of mouse Importin alpha in complex with Dengue 1 NS5 central NLS peptide Descriptor: Importin subunit alpha-1, RNA-directed RNA polymerase NS5 central NLS peptide Authors: Cheng, C.X, Swarbrick, C.M.D, Forward, J.K. Deposit date: 2024-01-16 Release date: 2024-08-21 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Serotype-Specific Regulation of Dengue Virus NS5 Protein Subcellular Localization. Acs Infect Dis., 10, 2024
7N9H	Structure of the mammalian importin a1 bound to the TDP-43 NLS Descriptor: Importin subunit alpha-1, TAR DNA-binding protein 43 Authors: Doll, S.G, Lokareddy, R.K, Cingolani, G. Deposit date: 2021-06-17 Release date: 2022-06-22 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Recognition of the TDP-43 nuclear localization signal by importin alpha 1/ beta. Cell Rep, 39, 2022
8TUU	MW Polyomavirus LTA bipartite NLS bound to importin alpha 2 Descriptor: Importin subunit alpha-1, Large T-antigen Authors: Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-17 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
8TUT	Merkel Cell Polyomavirus LTA NLSct bound to importin alpha 2 Descriptor: Importin subunit alpha-1, PRO-PRO-LYS-PRO-LYS-LYS-ASN-ARG-GLU Authors: Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-17 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.55 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
7NSC	Substrate receptor scaffolding module of human CTLH E3 ubiquitin ligase Descriptor: Glucose-induced degradation protein 4 homolog, Glucose-induced degradation protein 8 homolog, Isoform 2 of Armadillo repeat-containing protein 8, ... Authors: Chrustowicz, J, Sherpa, D, Prabu, J.R, Schulman, B.A. Deposit date: 2021-03-05 Release date: 2021-05-05 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme. Mol.Cell, 81, 2021
8TUR	Merkel Cell Polyomavirus LTA bipartite NLS bound to importin alpha 2 Descriptor: Importin subunit alpha-1, Truncated large T antigen Authors: Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-17 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.15 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
8TUQ	STL Polyomavirus LTA NLS bound to importin alpha 2 Descriptor: Importin subunit alpha-1, Large T antigen Authors: Donnelly, C.M, Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-17 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
8TUS	WU Polyomavirus LTA NLS bound to importin alpha 2 Descriptor: Importin subunit alpha-1, Large T antigen Authors: Donnelly, C.M, Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-17 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
5U5R	Crystal Structure and X-ray Diffraction Data Collection of Importin-alpha from Mus musculus Complexed with a PMS2 NLS Peptide Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Importin subunit alpha-1, Mismatch repair endonuclease PMS2 Authors: Barros, A.C, Takeda, A.A, Dreyer, T.R, Velazquez-Campoy, A, Kobe, B, Fontes, M.R. Deposit date: 2016-12-07 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.1 Å) Cite: DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway. Biochimie, 146, 2018
5SVZ	HIV-1 Tat NLS in complex with importin alpha Descriptor: Importin subunit alpha-1, Tat Authors: Smith, K.M, Himiari, Z, Forwood, J.K. Deposit date: 2016-08-08 Release date: 2016-08-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Basis for Importin-alpha Binding of the Human Immunodeficiency Virus Tat. Sci Rep, 7, 2017
5UMZ	Structure of TNRC6A NLS in complex with importin-alpha Descriptor: GLYCEROL, Importin subunit alpha-1, TNRC6A Authors: Chaston, J, Stewart, A.G, Christie, M. Deposit date: 2017-01-30 Release date: 2017-12-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha. PLoS ONE, 12, 2017
5V5O	Structure of NLS2K of influenza A virus nucleoprotein bound to importin alpha Descriptor: Importin subunit alpha-1, Nucleoprotein Authors: Sankhala, R.S, Lokareddy, R.K, Cingolani, G. Deposit date: 2017-03-14 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.243 Å) Cite: Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin alpha isoforms. Sci Rep, 7, 2017
5V5P	Structure of NLS2R of influenza A virus nucleoprotein bound to importin alpha Descriptor: Importin subunit alpha-1, Nucleoprotein Authors: Sankhala, R.S, Lokareddy, R.K, Cingolani, G. Deposit date: 2017-03-14 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin alpha isoforms. Sci Rep, 7, 2017
5U5P	Crystal Structure and X-ray Diffraction Data Collection of Importin-alpha from Mus Musculus Complexed with a MLH1 NLS Peptide Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, DNA mismatch repair protein Mlh1, Importin subunit alpha-1 Authors: Barros, A.C, Takeda, A.A, Dreyer, T.R, Velazquez-Campoy, A, Kobe, B, Fontes, M.R. Deposit date: 2016-12-07 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.171 Å) Cite: DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway. Biochimie, 146, 2018

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