7N9H

Structure of the mammalian importin a1 bound to the TDP-43 NLS

Summary for 7N9H

• Entry DOI: 10.2210/pdb7n9h/pdb
• Related: 4UAF
• Descriptor: Importin subunit alpha-1, TAR DNA-binding protein 43 (3 entities in total)
• Functional Keywords: nuclear import, importin alpha, nls, tdp-43, protein transport
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 49127.23

Authors

Doll, S.G.,Lokareddy, R.K.,Cingolani, G. (deposition date: 2021-06-17, release date: 2022-06-22, Last modification date: 2024-01-10)

• Primary citation: Doll, S.G.,Meshkin, H.,Bryer, A.J.,Li, F.,Ko, Y.H.,Lokareddy, R.K.,Gillilan, R.E.,Gupta, K.,Perilla, J.R.,Cingolani, G.; Recognition of the TDP-43 nuclear localization signal by importin alpha 1/ beta.; Cell Rep, 39:111007-111007, 2022; PubMed: 35767952; DOI: 10.1016/j.celrep.2022.111007

Experimental method

X-RAY DIFFRACTION (2.2 Å)