7N9H
Structure of the mammalian importin a1 bound to the TDP-43 NLS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | Importin subunit alpha-1 | polymer | 428 | 46386.1 | 1 | UniProt (P52292) Pfam (PF01749) Pfam (PF00514) Pfam (PF16186) | Homo sapiens (Human) | Karyopherin subunit alpha-2,RAG cohort protein 1,SRP1-alpha |
| 2 | B (A) | TAR DNA-binding protein 43 | polymer | 24 | 2741.2 | 1 | UniProt (Q13148) | Homo sapiens (Human) | TDP-43 |
| 3 | C, D (C, A) | water | water | 18.0 | 163 | Chemie (HOH) |
Sequence modifications
C: 70 - 497 (UniProt: P52292)
| PDB | External Database | Details |
|---|---|---|
| Glu 79 | Asp 79 | conflict |
| Asn 88 | Ser 88 | conflict |
| Leu 90 | Val 90 | conflict |
| Ser 92 | Asn 92 | conflict |
| Lys 130 | Arg 130 | conflict |
| Ala 195 | Val 195 | conflict |
| His 203 | Tyr 203 | conflict |
| Ile 206 | Val 206 | conflict |
| Leu 218 | Met 218 | conflict |
| Thr 220 | Ser 220 | conflict |
| Leu 246 | Ile 246 | conflict |
| Asn 263 | Asp 263 | conflict |
| Ser 271 | Thr 271 | conflict |
| Glu 287 | Gly 287 | conflict |
| Lys 292 | Thr 292 | conflict |
| Thr 305 | Ser 305 | conflict |
| Lys 330 | Val 330 | conflict |
| Gly 384 | Ser 384 | conflict |
| Ala 398 | Val 398 | conflict |
| Ile 401 | Val 401 | conflict |
| Ser 430 | Thr 430 | conflict |
| Gln 438 | Leu 438 | conflict |
| Arg 478 | Asn 478 | conflict |
| Asn 490 | Ser 490 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49127.2 | |
| All* | Total formula weight | 49127.2 |
