7N9H

Structure of the mammalian importin a1 bound to the TDP-43 NLS

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	C	Importin subunit alpha-1	polymer	428	46386.1	1	UniProt (P52292) Pfam (PF01749) Pfam (PF00514) Pfam (PF16186) In PDB	Homo sapiens (Human)	Karyopherin subunit alpha-2,RAG cohort protein 1,SRP1-alpha
2	A	TAR DNA-binding protein 43	polymer	24	2741.2	1	UniProt (Q13148) In PDB	Homo sapiens (Human)	TDP-43
3		water	water		18.0	163	Chemie (HOH)

Sequence modifications

C: 70 - 497 (UniProt: P52292)

PDB	External Database	Details
Glu 79	Asp 79	conflict
Asn 88	Ser 88	conflict
Leu 90	Val 90	conflict
Ser 92	Asn 92	conflict
Lys 130	Arg 130	conflict
Ala 195	Val 195	conflict
His 203	Tyr 203	conflict
Ile 206	Val 206	conflict
Leu 218	Met 218	conflict
Thr 220	Ser 220	conflict
Leu 246	Ile 246	conflict
Asn 263	Asp 263	conflict
Ser 271	Thr 271	conflict
Glu 287	Gly 287	conflict
Lys 292	Thr 292	conflict
Thr 305	Ser 305	conflict
Lys 330	Val 330	conflict
Gly 384	Ser 384	conflict
Ala 398	Val 398	conflict
Ile 401	Val 401	conflict
Ser 430	Thr 430	conflict
Gln 438	Leu 438	conflict
Arg 478	Asn 478	conflict
Asn 490	Ser 490	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	49127.2
All*	Total formula weight	49127.2

*Water molecules are not included.