7N9H
Structure of the mammalian importin a1 bound to the TDP-43 NLS
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | C | Importin subunit alpha-1 | polymer | 428 | 46386.1 | 1 | UniProt (P52292) Pfam (PF01749) Pfam (PF00514) Pfam (PF16186) In PDB | Homo sapiens (Human) | Karyopherin subunit alpha-2,RAG cohort protein 1,SRP1-alpha |
2 | A | TAR DNA-binding protein 43 | polymer | 24 | 2741.2 | 1 | UniProt (Q13148) In PDB | Homo sapiens (Human) | TDP-43 |
3 | water | water | 18.0 | 163 | Chemie (HOH) |
Sequence modifications
C: 70 - 497 (UniProt: P52292)
PDB | External Database | Details |
---|---|---|
Glu 79 | Asp 79 | conflict |
Asn 88 | Ser 88 | conflict |
Leu 90 | Val 90 | conflict |
Ser 92 | Asn 92 | conflict |
Lys 130 | Arg 130 | conflict |
Ala 195 | Val 195 | conflict |
His 203 | Tyr 203 | conflict |
Ile 206 | Val 206 | conflict |
Leu 218 | Met 218 | conflict |
Thr 220 | Ser 220 | conflict |
Leu 246 | Ile 246 | conflict |
Asn 263 | Asp 263 | conflict |
Ser 271 | Thr 271 | conflict |
Glu 287 | Gly 287 | conflict |
Lys 292 | Thr 292 | conflict |
Thr 305 | Ser 305 | conflict |
Lys 330 | Val 330 | conflict |
Gly 384 | Ser 384 | conflict |
Ala 398 | Val 398 | conflict |
Ile 401 | Val 401 | conflict |
Ser 430 | Thr 430 | conflict |
Gln 438 | Leu 438 | conflict |
Arg 478 | Asn 478 | conflict |
Asn 490 | Ser 490 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 49127.2 | |
All* | Total formula weight | 49127.2 |