8E9Z
| CryoEM structure of miniGq-coupled hM3R in complex with Iperoxo | Descriptor: | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhang, S, Fay, J.F, Roth, B.L. | Deposit date: | 2022-08-27 | Release date: | 2022-11-30 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (2.69 Å) | Cite: | Molecular basis for selective activation of DREADD-based chemogenetics. Nature, 612, 2022
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8E3I
| CRYO-EM STRUCTURE OF the human MPSF IN COMPLEX WITH THE AUUAAA poly(A) signal | Descriptor: | Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, RNA (5'-R(P*CP*AP*UP*UP*AP*AP*AP*CP*AP*AP*C)-3'), ... | Authors: | Gutierrez, P.A, Wei, J, Sun, Y, Tong, L. | Deposit date: | 2022-08-17 | Release date: | 2023-01-18 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.53 Å) | Cite: | Molecular basis for the recognition of the AUUAAA polyadenylation signal by mPSF. Rna, 28, 2022
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8E3Q
| CRYO-EM STRUCTURE OF the human MPSF | Descriptor: | Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, ZINC ION, ... | Authors: | Gutierrez, P.A, Wei, J, Sun, Y, Tong, L. | Deposit date: | 2022-08-17 | Release date: | 2023-01-18 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.68 Å) | Cite: | Molecular basis for the recognition of the AUUAAA polyadenylation signal by mPSF. Rna, 28, 2022
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8E9B
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8E5T
| Yeast co-transcriptional Noc1-Noc2 RNP assembly checkpoint intermediate | Descriptor: | 25S ribosomal RNA, 5.8S ribosomal RNA, 60S ribosomal protein L13-A, ... | Authors: | Sanghai, Z.A, Piwowarczyk, R, Vanden Broeck, A, Klinge, S. | Deposit date: | 2022-08-22 | Release date: | 2023-04-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | A co-transcriptional ribosome assembly checkpoint controls nascent large ribosomal subunit maturation. Nat.Struct.Mol.Biol., 30, 2023
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8DZP
| momSalB bound Kappa Opioid Receptor in complex with Gi1 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Fay, J.F, Che, T. | Deposit date: | 2022-08-08 | Release date: | 2023-05-03 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (2.71 Å) | Cite: | Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
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8DZQ
| momSalB bound Kappa Opioid Receptor in complex with GoA | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ... | Authors: | Fay, J.F, Che, T. | Deposit date: | 2022-08-08 | Release date: | 2023-05-03 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (2.82 Å) | Cite: | Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
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8DZS
| GR89,696 bound Kappa Opioid Receptor in complex with Gz | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(z) subunit alpha, ... | Authors: | Fay, J.F, Che, T. | Deposit date: | 2022-08-08 | Release date: | 2023-05-03 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (2.65 Å) | Cite: | Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
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8DZR
| GR89,696 bound Kappa Opioid Receptor in complex with gustducin | Descriptor: | G alpha gustducin protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Fay, J.F, Che, T. | Deposit date: | 2022-08-08 | Release date: | 2023-05-03 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (2.61 Å) | Cite: | Ligand and G-protein selectivity in the kappa-opioid receptor. Nature, 617, 2023
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8EUG
| Ytm1 associated nascent 60S ribosome State 3 | Descriptor: | 60S ribosomal protein L10-A, 60S ribosomal protein L11-A, 60S ribosomal protein L13, ... | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | Deposit date: | 2022-10-18 | Release date: | 2022-11-30 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis. Mol.Cell, 82, 2022
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8ESQ
| Ytm1 associated nascent 60S ribosome State 2 | Descriptor: | 25S rRNA (cytosine-C(5))-methyltransferase nop2, 60S ribosomal protein L13, 60S ribosomal protein L14, ... | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | Deposit date: | 2022-10-14 | Release date: | 2022-11-30 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis. Mol.Cell, 82, 2022
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8EUY
| Ytm1 associated nascent 60S ribosome (-fkbp39) State 1A | Descriptor: | 60S ribosomal protein L13, 60S ribosomal protein L14, 60S ribosomal protein L15-A, ... | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | Deposit date: | 2022-10-19 | Release date: | 2022-11-30 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis. Mol.Cell, 82, 2022
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8EUI
| Ytm1 associated nascent 60S ribosome (-fkbp39) State 3 | Descriptor: | 60S ribosomal protein L10-A, 60S ribosomal protein L11-A, 60S ribosomal protein L13, ... | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | Deposit date: | 2022-10-18 | Release date: | 2022-11-30 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis. Mol.Cell, 82, 2022
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8ETH
| Ytm1 associated 60S nascent ribosome State 1B | Descriptor: | 60S ribosomal protein L13, 60S ribosomal protein L14, 60S ribosomal protein L15-A, ... | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | Deposit date: | 2022-10-17 | Release date: | 2022-11-30 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis. Mol.Cell, 82, 2022
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8ESR
| Ytm1 associated nascent 60S ribosome (-fkbp39) State 2 | Descriptor: | 25S rRNA (cytosine-C(5))-methyltransferase nop2, 60S ribosomal protein L13, 60S ribosomal protein L14, ... | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | Deposit date: | 2022-10-14 | Release date: | 2022-11-30 | Last modified: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis. Mol.Cell, 82, 2022
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8ETI
| Fkbp39 associated 60S nascent ribosome State 1 | Descriptor: | 60S ribosomal protein L13, 60S ribosomal protein L14, 60S ribosomal protein L15-A, ... | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | Deposit date: | 2022-10-17 | Release date: | 2022-11-30 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis. Mol.Cell, 82, 2022
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8EUP
| Ytm1 associated 60S nascent ribosome State 1A | Descriptor: | 60S ribosomal protein L13, 60S ribosomal protein L14, 60S ribosomal protein L15-A, ... | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | Deposit date: | 2022-10-19 | Release date: | 2022-11-30 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis. Mol.Cell, 82, 2022
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7Y35
| Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex | Descriptor: | Abaloparatide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z. | Deposit date: | 2022-06-09 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex To Be Published
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7Y36
| Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, HYDROXIDE ION, ... | Authors: | Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z. | Deposit date: | 2022-06-10 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex to be published
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7XZ5
| GPR119-Gs-LPC complex | Descriptor: | (4R,7R,18E)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, P, Huang, S, Jiang, Y, Xu, H.E. | Deposit date: | 2022-06-02 | Release date: | 2022-08-24 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119. Nat.Struct.Mol.Biol., 29, 2022
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7XZ6
| GPR119-Gs-APD668 complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Xu, P, Huang, S, Jiang, Y, Xu, H.E. | Deposit date: | 2022-06-02 | Release date: | 2022-08-24 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119. Nat.Struct.Mol.Biol., 29, 2022
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7XW5
| TSHR-thyroid stimulating hormone-Gs-ML109 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, Glycoprotein hormones alpha chain, ... | Authors: | Duan, J, Xu, P, Luan, X, Ji, Y, Yuan, Q, He, X, Ye, J, Cheng, X, Jiang, H, Zhang, S, Jiang, Y, Xu, H.E. | Deposit date: | 2022-05-26 | Release date: | 2022-08-24 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Hormone- and antibody-mediated activation of the thyrotropin receptor. Nature, 609, 2022
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7XTQ
| Cryo-EM structure of the R399-bound GPBAR-Gs complex | Descriptor: | G-protein coupled bile acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Ma, L, Yang, F, Wu, X, Mao, C, Sun, J, Yu, X, Zhang, Y, Zhang, P. | Deposit date: | 2022-05-17 | Release date: | 2022-07-06 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity. Proc.Natl.Acad.Sci.USA, 119, 2022
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7Y24
| Cryo-EM structure of the octreotide-bound SSTR2-miniGo-scFv16 complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ... | Authors: | Chen, S, Zheng, S. | Deposit date: | 2022-06-09 | Release date: | 2022-10-19 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Molecular basis for the selective G protein signaling of somatostatin receptors. Nat.Chem.Biol., 19, 2023
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7Y27
| Cryo-EM structure of the SST-14-bound SSTR2-miniGq-scFv16 complex | Descriptor: | CHOLESTEROL, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Chen, S, Zheng, S. | Deposit date: | 2022-06-09 | Release date: | 2022-10-19 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | Molecular basis for the selective G protein signaling of somatostatin receptors. Nat.Chem.Biol., 19, 2023
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