8E3I

CRYO-EM STRUCTURE OF the human MPSF IN COMPLEX WITH THE AUUAAA poly(A) signal

Summary for 8E3I

• Entry DOI: 10.2210/pdb8e3i/pdb
• EMDB information: 27866
• Descriptor: Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, RNA (5'-R(P*CP*AP*UP*UP*AP*AP*AP*CP*AP*AP*C)-3'), ... (5 entities in total)
• Functional Keywords: mrna, 3'processing, polyadenylation, cpsf, rna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 258286.71

Authors

Gutierrez, P.A.,Wei, J.,Sun, Y.,Tong, L. (deposition date: 2022-08-17, release date: 2023-01-18, Last modification date: 2024-06-12)

• Primary citation: Gutierrez, P.A.,Wei, J.,Sun, Y.,Tong, L.; Molecular basis for the recognition of the AUUAAA polyadenylation signal by mPSF.; Rna, 28:1534-1541, 2022; PubMed: 36130077; DOI: 10.1261/rna.079322.122

Experimental method

ELECTRON MICROSCOPY (2.53 Å)