8E3I
CRYO-EM STRUCTURE OF the human MPSF IN COMPLEX WITH THE AUUAAA poly(A) signal
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cleavage and polyadenylation specificity factor subunit 1 | polymer | 1443 | 161074.2 | 1 | UniProt (Q10570) Pfam (PF10433) Pfam (PF23726) Pfam (PF03178) | Homo sapiens (human) | Cleavage and polyadenylation specificity factor 160 kDa subunit, CPSF 160 kDa subunit |
| 2 | B (C) | Cleavage and polyadenylation specificity factor subunit 4 | polymer | 245 | 27646.1 | 1 | UniProt (O95639) Pfam (PF15663) Pfam (PF00642) Pfam (PF00098) | Homo sapiens (human) | Cleavage and polyadenylation specificity factor 30 kDa subunit, CPSF 30 kDa subunit, NS1 effector domain-binding protein 1, Neb-1, No arches homolog |
| 3 | C (E) | RNA (5'-R(P*CP*AP*UP*UP*AP*AP*AP*CP*AP*AP*C)-3') | polymer | 11 | 3458.2 | 1 | Homo sapiens | ||
| 4 | D (B) | pre-mRNA 3' end processing protein WDR33 | polymer | 572 | 65912.0 | 1 | UniProt (Q9C0J8) Pfam (PF00400) | Homo sapiens (human) | WD repeat-containing protein 33,WD repeat-containing protein of 146 kDa |
| 5 | E, F, G (C) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) PubChem (32051) |
Sequence modifications
C: 1 - 244 (UniProt: O95639)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 258090.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 196.2 | |
| All* | Total formula weight | 258286.7 |
