PDB: 499 resultsInfo pagesStatus searchChemie searchBIRD

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4ZPK	Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with HRE DNA Descriptor: Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(*CP*AP*CP*GP*AP*CP*CP*CP*GP*CP*AP*CP*GP*TP*AP*CP*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ... Authors: Wu, D, Potluri, N, Lu, J, Kim, Y, Rastinejad, F. Deposit date: 2015-05-08 Release date: 2015-08-12 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structural integration in hypoxia-inducible factors. Nature, 524, 2015
4ZP4	Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex Descriptor: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 Authors: Wu, D, Potluri, N, Lu, J, Kim, Y, Rastinejad, F. Deposit date: 2015-05-07 Release date: 2015-08-12 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.355 Å) Cite: Structural integration in hypoxia-inducible factors. Nature, 524, 2015
4ZPH	Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with Proflavine Descriptor: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, PROFLAVIN Authors: Wu, D, Potluri, N, Lu, J, Kim, Y, Rastinejad, F. Deposit date: 2015-05-07 Release date: 2015-08-12 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural integration in hypoxia-inducible factors. Nature, 524, 2015
6MGM	Helix-Loop-helix motif of mouse DNA-binding protein inhibitor ID-1 Descriptor: DNA-binding protein inhibitor ID-1 Authors: Benezra, R, Pavletich, N.P, Goldgur, Y, Gall, A.-L. Deposit date: 2018-09-14 Release date: 2019-09-18 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.791 Å) Cite: A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep, 29, 2019
7SSA	Cryo-EM structure of pioneer factor Cbf1 bound to the nucleosome Descriptor: Centromere-binding protein 1, DNA (137-MER), Histone H2A.1, ... Authors: Eek, P, Tan, S. Deposit date: 2021-11-10 Release date: 2023-04-05 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions. Mol.Cell, 83, 2023
3PXP	Crystal structure of a PAS and DNA binding domain containing protein (Caur_2278) from CHLOROFLEXUS AURANTIACUS J-10-FL at 2.30 A resolution Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Helix-turn-helix domain protein, ... Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2010-12-10 Release date: 2011-01-19 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of an MmyB-Like Regulator from C. aurantiacus, Member of a New Transcription Factor Family Linked to Antibiotic Metabolism in Actinomycetes. Plos One, 7, 2012
2UYZ	Non-covalent complex between Ubc9 and SUMO1 Descriptor: SMALL UBIQUITIN-RELATED MODIFIER 1, SODIUM ION, SUMO-CONJUGATING ENZYME UBC9 Authors: Knipscheer, P, van Dijk, W.J, Olsen, J.V, Mann, M, Sixma, T.K. Deposit date: 2007-04-21 Release date: 2007-06-12 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation. EMBO J., 26, 2007
2VRR	Structure of SUMO modified Ubc9 Descriptor: FORMIC ACID, SMALL UBIQUITIN-RELATED MODIFIER 1, SODIUM ION, ... Authors: Knipscheer, P, Flotho, A, Klug, H, Olsen, J.V, van Dijk, W.J, Fish, A, Johnson, E.S, Mann, M, Sixma, T.K, Pichler, A. Deposit date: 2008-04-13 Release date: 2008-08-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.22 Å) Cite: Ubc9 sumoylation regulates SUMO target discrimination. Mol. Cell, 31, 2008
7V7L	Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex Descriptor: Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 3-alpha Authors: Diao, X, Ren, X, Li, F.W, Sun, X, Wu, D. Deposit date: 2021-08-21 Release date: 2022-05-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Identification of oleoylethanolamide as an endogenous ligand for HIF-3 alpha. Nat Commun, 13, 2022
4KFZ	Crystal structure of LMO2 and anti-LMO2 VH complex Descriptor: Anti-LMO2 VH, LMO-2, ZINC ION Authors: Sewell, H, Tanaka, T, El Omari, K, Cruz-Migoni, A, Mancini, E.J, Fuentes-Fernandez, N, Chambers, J, Rabbitts, T.H. Deposit date: 2013-04-28 Release date: 2014-01-22 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex. Sci Rep, 4, 2014
5ZD4	Crystal structure of MBP-fused BIL1/BZR1 in complex with double-stranded DNA Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*TP*TP*CP*AP*CP*AP*CP*GP*TP*GP*TP*GP*AP*AP*A)-3'), Maltose-binding periplasmic protein,Protein BRASSINAZOLE-RESISTANT 1, ... Authors: Nosaki, S, Miyakawa, T, Xu, Y, Nakamura, A, Hirabayashi, K, Tanokura, M. Deposit date: 2018-02-22 Release date: 2018-08-29 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Structural basis for brassinosteroid response by BIL1/BZR1. Nat Plants, 4, 2018
6A5Q	Structure of 14-3-3 beta in complex with TFEB 14-3-3 binding motif Descriptor: 14-3-3 protein beta/alpha, MALONIC ACID, TFEB pS211-peptide Authors: Xu, Y, Ren, J.Q, Feng, W. Deposit date: 2018-06-25 Release date: 2019-02-13 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. Autophagy, 15, 2019
7F2F	The complex of DNA with the C-terminal domain of TYE7 from Saccharomyces cerevisiae. Descriptor: DNA (5'-D(*CP*AP*GP*AP*TP*CP*AP*TP*GP*TP*GP*TP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*CP*AP*CP*AP*CP*AP*TP*GP*AP*TP*CP*T)-3'), Serine-rich protein TYE7 Authors: Gui, W. Deposit date: 2021-06-10 Release date: 2021-10-13 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Crystal structure of the complex of DNA with the C-terminal domain of TYE7 from Saccharomyces cerevisiae. Acta Crystallogr.,Sect.F, 77, 2021
8QMO	Cryo-EM structure of the benzo[a]pyrene-bound Hsp90-XAP2-AHR complex Descriptor: ADENOSINE-5'-DIPHOSPHATE, AH receptor-interacting protein, Aryl hydrocarbon receptor, ... Authors: Kwong, H.S, Grandvuillemin, L, Sirounian, S, Ancelin, A, Lai-Kee-Him, J, Carivenc, C, Lancey, C, Ragan, T.J, Hesketh, E.L, Bourguet, W, Gruszczyk, J. Deposit date: 2023-09-24 Release date: 2024-01-10 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (2.76 Å) Cite: Structural Insights into the Activation of Human Aryl Hydrocarbon Receptor by the Environmental Contaminant Benzo[a]pyrene and Structurally Related Compounds. J.Mol.Biol., 436, 2024
7VNI	AHR-ARNT PAS-B heterodimer Descriptor: Ahr homolog spineless, Aryl hydrocarbon receptor nuclear translocator, SULFATE ION Authors: Dai, S.Y. Deposit date: 2021-10-11 Release date: 2022-04-13 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.997 Å) Cite: Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor. Nat Commun, 13, 2022
7VNA	drosophlia AHR PAS-B domain Descriptor: Ahr homolog spineless Authors: Dai, S.Y. Deposit date: 2021-10-10 Release date: 2022-04-13 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.597 Å) Cite: Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor. Nat Commun, 13, 2022
7VNH	drosophlia AHR PAS-B domain bound by the antagonist alpha-naphthoflavone Descriptor: 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE, Ahr homolog spineless Authors: Dai, S.Y. Deposit date: 2021-10-11 Release date: 2022-04-13 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.402 Å) Cite: Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor. Nat Commun, 13, 2022
5I4V	Discovery of novel, orally efficacious Liver X Receptor (LXR) beta agonists Descriptor: Oxysterols receptor LXR-beta,Nuclear receptor coactivator 2, Retinoic acid receptor RXR-beta,Nuclear receptor coactivator 2, {2-[(2R)-4-[4-(hydroxymethyl)-3-(methylsulfonyl)phenyl]-2-(propan-2-yl)piperazin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanol Authors: Chen, G, McKeever, B.M. Deposit date: 2016-02-12 Release date: 2016-06-29 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.61 Å) Cite: Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) beta Agonist. J.Med.Chem., 59, 2016
6CZW	Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex Descriptor: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, {2-bromo-3-(3-chloro-5-fluorophenoxy)-6-[(difluoromethyl)sulfonyl]phenyl}methanol Authors: Du, X. Deposit date: 2018-04-09 Release date: 2018-10-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex To Be Published
6D09	Crystal structure of PT2440 bound to HIF2a-B*:ARNT-B* complex Descriptor: 3-{[(3R)-4-(difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-dioxo-2,3-dihydro-1H-1-benzothiophen-5-yl]oxy}-5-fluorobenzonitrile, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 Authors: Du, X. Deposit date: 2018-04-10 Release date: 2018-10-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex To Be Published
6D0C	Crystal structure of HIF2a-B*:ARNT-B* complex Descriptor: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 Authors: Du, X. Deposit date: 2018-04-10 Release date: 2018-10-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex To Be Published
6D0B	Crystal structure of PT1614 bound to HIF2a-B*:ARNT-B* complex Descriptor: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, N-(3-chloro-5-fluorophenyl)-2-nitro-4-[(trifluoromethyl)sulfonyl]aniline Authors: Du, X. Deposit date: 2018-04-10 Release date: 2018-10-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal structure of PT1614 bound to HIF2a-B*:ARNT-B* complex To Be Published
4XT2	Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with a tetrazole-containing antagonist Descriptor: (5S,7R)-5,7-bis(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 Authors: Scheuermann, T.H, Gardner, K.H. Deposit date: 2015-01-22 Release date: 2015-12-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.698 Å) Cite: Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2. J.Med.Chem., 58, 2015
6X28	Crystal structure of PT2243 bound to HIF2a-B*:ARNT-B* complex Descriptor: (1R)-4-(3,5-difluorophenoxy)-7-(trifluoromethyl)-2,3-dihydro-1H-inden-1-ol, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 Authors: Du, X. Deposit date: 2020-05-20 Release date: 2021-05-26 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Crystal structure of PT2243 bound to HIF2-PasB*:ARNT-PasB* complex To Be Published
6X37	Crystal structure of PT3245 bound to HIF2a-B*:ARNT-B* complex Descriptor: 3-fluoro-5-{[(7R)-7-hydroxy-1-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-4-yl]oxy}benzonitrile, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 Authors: Du, X. Deposit date: 2020-05-21 Release date: 2021-05-26 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Crystal structure of PT3245 bound to HIF2a-B*:ARNT-B* complex To Be Published

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