4XT2

Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with a tetrazole-containing antagonist

Summary for 4XT2

Entry DOI	10.2210/pdb4xt2/pdb
Related	3F1O 3F1P 3H82 3HW7 4GHI 4GS9 4LPZ
Descriptor	Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, (5S,7R)-5,7-bis(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine, ... (4 entities in total)
Functional Keywords	transcription factor, hypoxia inducible factor, inhibitor, cancer, transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	56433.03
Authors	Scheuermann, T.H.,Gardner, K.H. (deposition date: 2015-01-22, release date: 2015-12-09, Last modification date: 2023-09-27)
Primary citation	Scheuermann, T.H.,Stroud, D.,Sleet, C.E.,Bayeh, L.,Shokri, C.,Wang, H.,Caldwell, C.G.,Longgood, J.,MacMillan, J.B.,Bruick, R.K.,Gardner, K.H.,Tambar, U.K. Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2. J.Med.Chem., 58:5930-5941, 2015 Cited by PubMed: 26226049 DOI: 10.1021/acs.jmedchem.5b00529 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.698 Å)

Structure validation