4GS9

Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with an inactive benzoxadiazole antagonist

Summary for 4GS9

Entry DOI	10.2210/pdb4gs9/pdb
Related	1P97 1X0O 2A24 2B02 3F1N 3F1O 3F1P 3H7W 3H82 4GHI
Descriptor	Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, N-(3-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine, ... (5 entities in total)
Functional Keywords	pas fold, transcription, protein-protein interactions, nucleus
Biological source	Homo sapiens (human) More
Cellular location	Nucleus : Q99814 P27540
Total number of polymer chains	2
Total formula weight	28426.04
Authors	Scheuermann, T.H.,Gardner, K.H. (deposition date: 2012-08-27, release date: 2013-04-03, Last modification date: 2023-09-13)
Primary citation	Rogers, J.L.,Bayeh, L.,Scheuermann, T.H.,Longgood, J.,Key, J.,Naidoo, J.,Melito, L.,Shokri, C.,Frantz, D.E.,Bruick, R.K.,Gardner, K.H.,Macmillan, J.B.,Tambar, U.K. Development of Inhibitors of the PAS-B Domain of the HIF-2 alpha Transcription Factor J.Med.Chem., 56:1739-1747, 2013 Cited by PubMed: 23363003 DOI: 10.1021/jm301847z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.72 Å)

Structure validation