6D09

Crystal structure of PT2440 bound to HIF2a-B*:ARNT-B* complex

Summary for 6D09

• Entry DOI: 10.2210/pdb6d09/pdb
• Related: 6CZW
• Descriptor: Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, 3-{[(3R)-4-(difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-dioxo-2,3-dihydro-1H-1-benzothiophen-5-yl]oxy}-5-fluorobenzonitrile, ... (4 entities in total)
• Functional Keywords: hif2a, pas b domain, arnt, hypoxia inducible factor, epas1, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 28186.69

Authors

Du, X. (deposition date: 2018-04-10, release date: 2018-10-31, Last modification date: 2023-10-04)

• Primary citation: Du, X.; Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.85 Å)