6CZW

Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex

Summary for 6CZW

DescriptorEndothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, {2-bromo-3-(3-chloro-5-fluorophenoxy)-6-[(difluoromethyl)sulfonyl]phenyl}methanol, ... (4 entities in total)
Functional Keywordshif2a, pas b domain, arnt, hypoxia inducible factor, epas1, transcription
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight28227.03
Authors
Du, X. (deposition date: 2018-04-09, release date: 2018-10-31)
Primary citation
Du, X.
Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2048 0.5% 3.0% 4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution