2OT8
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![BU of 2ot8 by Molmil](/molmil-images/mine/2ot8) | |
2P8Q
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![BU of 2p8q by Molmil](/molmil-images/mine/2p8q) | |
7DBG
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![BU of 7dbg by Molmil](/molmil-images/mine/7dbg) | Yeast CRM1e (apo) in complex with Ran-RanBP1 | Descriptor: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, CRM1 isoform 1, ... | Authors: | Sun, Q, Lei, Y. | Deposit date: | 2020-10-20 | Release date: | 2021-09-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin. J.Nat.Prod., 84, 2021
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2Q5D
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![BU of 2q5d by Molmil](/molmil-images/mine/2q5d) | |
1O6P
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![BU of 1o6p by Molmil](/molmil-images/mine/1o6p) | |
1O6O
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![BU of 1o6o by Molmil](/molmil-images/mine/1o6o) | |
8DYO
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![BU of 8dyo by Molmil](/molmil-images/mine/8dyo) | Cryo-EM structure of Importin-4 bound to RanGTP | Descriptor: | GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-4, ... | Authors: | Bernardes, N.E, Fung, H.Y.J, Li, Y, Chen, Z, Chook, Y.M. | Deposit date: | 2022-08-04 | Release date: | 2022-09-21 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (7.1 Å) | Cite: | Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex. Proc.Natl.Acad.Sci.USA, 119, 2022
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1QGR
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![BU of 1qgr by Molmil](/molmil-images/mine/1qgr) | STRUCTURE OF IMPORTIN BETA BOUND TO THE IBB DOMAIN OF IMPORTIN ALPHA (II CRYSTAL FORM, GROWN AT LOW PH) | Descriptor: | PROTEIN (IMPORTIN ALPHA-2 SUBUNIT), PROTEIN (IMPORTIN BETA SUBUNIT) | Authors: | Cingolani, G, Petosa, C, Weis, K, Muller, C.W. | Deposit date: | 1999-05-04 | Release date: | 1999-05-24 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of importin-beta bound to the IBB domain of importin-alpha. Nature, 399, 1999
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1QGK
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![BU of 1qgk by Molmil](/molmil-images/mine/1qgk) | STRUCTURE OF IMPORTIN BETA BOUND TO THE IBB DOMAIN OF IMPORTIN ALPHA | Descriptor: | PROTEIN (IMPORTIN ALPHA-2 SUBUNIT), PROTEIN (IMPORTIN BETA SUBUNIT) | Authors: | Cingolani, G, Petosa, C, Weis, K, Muller, C.W. | Deposit date: | 1999-04-29 | Release date: | 1999-05-24 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of importin-beta bound to the IBB domain of importin-alpha. Nature, 399, 1999
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8F7A
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![BU of 8f7a by Molmil](/molmil-images/mine/8f7a) | Cryo-EM structure of Importin-9 bound to RanGTP | Descriptor: | GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-9, ... | Authors: | Bernardes, N.E, Chook, Y.M. | Deposit date: | 2022-11-18 | Release date: | 2023-07-26 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.78 Å) | Cite: | Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. Proc.Natl.Acad.Sci.USA, 120, 2023
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8F0X
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![BU of 8f0x by Molmil](/molmil-images/mine/8f0x) | Cryo-EM structure of Kap114 bound to H2A-H2B | Descriptor: | Histone H2A.2, Histone H2B.2, Importin subunit beta-5 | Authors: | Jiou, J, Chook, Y.M. | Deposit date: | 2022-11-04 | Release date: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. Proc.Natl.Acad.Sci.USA, 120, 2023
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8F1E
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![BU of 8f1e by Molmil](/molmil-images/mine/8f1e) | Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP) and H2A-H2B | Descriptor: | GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Histone H2A.2, ... | Authors: | Jiou, J, Chook, Y.M. | Deposit date: | 2022-11-04 | Release date: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. Proc.Natl.Acad.Sci.USA, 120, 2023
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8F19
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![BU of 8f19 by Molmil](/molmil-images/mine/8f19) | Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP) | Descriptor: | GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin subunit beta-5, ... | Authors: | Jiou, J, Chook, Y.M. | Deposit date: | 2022-11-04 | Release date: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. Proc.Natl.Acad.Sci.USA, 120, 2023
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1QBK
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![BU of 1qbk by Molmil](/molmil-images/mine/1qbk) | |
8HQ3
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![BU of 8hq3 by Molmil](/molmil-images/mine/8hq3) | KL1 in complex with CRM1-Ran-RanBP1 | Descriptor: | CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ... | Authors: | Sun, Q, Jian, L. | Deposit date: | 2022-12-13 | Release date: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J.Med.Chem., 66, 2023
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8HQ6
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![BU of 8hq6 by Molmil](/molmil-images/mine/8hq6) | KL2 in complex with CRM1-Ran-RanBP1 | Descriptor: | CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ... | Authors: | Sun, Q, Jian, L. | Deposit date: | 2022-12-13 | Release date: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J.Med.Chem., 66, 2023
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8HQ5
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![BU of 8hq5 by Molmil](/molmil-images/mine/8hq5) | G6 in complex with CRM1-Ran-RanBP1 | Descriptor: | 3-[(4-bromophenyl)carbonylamino]-4-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]benzoic acid, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... | Authors: | Sun, Q, Lei, Y. | Deposit date: | 2022-12-13 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | F1 in complex with CRM1-Ran-RanBP1 To Be Published
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8HQ4
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![BU of 8hq4 by Molmil](/molmil-images/mine/8hq4) | B27 in complex with CRM1-Ran-RanBP1 | Descriptor: | 3-[(4-fluorophenyl)carbonylamino]-4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ... | Authors: | Lei, Y, Sun, Q. | Deposit date: | 2022-12-13 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | B27 in complex with CRM1-Ran-RanBP1 To Be Published
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8HUF
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![BU of 8huf by Molmil](/molmil-images/mine/8huf) | B28 in complex with CRM1-Ran-RanBP1 | Descriptor: | 3-[(4-chlorophenyl)carbonylamino]-4-[4-(2,5-dimethylphenyl)piperazin-1-yl]benzoic acid, BROMIDE ION, CHLORIDE ION, ... | Authors: | Sun, Q, Lei, Y. | Deposit date: | 2022-12-23 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | B28 in complex with CRM1-Ran-RanBP1 To Be Published
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8HUG
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![BU of 8hug by Molmil](/molmil-images/mine/8hug) | F1 in complex with CRM1-Ran-RanBP1 | Descriptor: | 4-[4-(3-chlorophenyl)piperazin-1-yl]-3-[(3-fluorophenyl)sulfonylamino]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ... | Authors: | Sun, Q, Lei, Y. | Deposit date: | 2022-12-23 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | F1 in complex with CRM1-Ran-RanBP1 To Be Published
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6M6X
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![BU of 6m6x by Molmil](/molmil-images/mine/6m6x) | Oridonin in complex with CRM1#-Ran-RanBP1 | Descriptor: | (1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one, 1,2-ETHANEDIOL, CHLORIDE ION, ... | Authors: | Sun, Q, Lei, Y. | Deposit date: | 2020-03-16 | Release date: | 2021-03-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.88 Å) | Cite: | Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin. J.Nat.Prod., 84, 2021
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6LQ9
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![BU of 6lq9 by Molmil](/molmil-images/mine/6lq9) | S109 in complex with CRM1-Ran-RanBP1 | Descriptor: | (3~{R},4~{S})-1-[[6-chloranyl-5-(trifluoromethyl)pyridin-2-yl]amino]-3,4-dimethyl-pyrrolidine-2,5-dione, CHLORIDE ION, Exportin-1, ... | Authors: | Sun, Q, Lei, Y. | Deposit date: | 2020-01-13 | Release date: | 2021-06-23 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure-Guided Design of the First Noncovalent Small-Molecule Inhibitor of CRM1. J.Med.Chem., 64, 2021
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6M60
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![BU of 6m60 by Molmil](/molmil-images/mine/6m60) | Plumbagin in complex with CRM1#-Ran-RanBP1 | Descriptor: | (2~{R})-2-methyl-5-oxidanyl-2,3-dihydronaphthalene-1,4-dione, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | Authors: | Sun, Q, Lei, Y. | Deposit date: | 2020-03-12 | Release date: | 2021-06-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin. J.Nat.Prod., 84, 2021
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6N88
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![BU of 6n88 by Molmil](/molmil-images/mine/6n88) | |
5DHA
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![BU of 5dha by Molmil](/molmil-images/mine/5dha) | |