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2OT8
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BU of 2ot8 by Molmil
Karyopherin Beta2/Transportin-hnRNPM NLS Complex
Descriptor: Heterogeneous nuclear ribonucleoprotein M, Transportin-1
Authors:Cansizoglu, A.E, Chook, Y.M.
Deposit date:2007-02-07
Release date:2007-04-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-based design of a pathway-specific nuclear import inhibitor.
Nat.Struct.Mol.Biol., 14, 2007
2P8Q
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BU of 2p8q by Molmil
Crystal Structure of human Importin beta bound to the Snurportin1 IBB-domain
Descriptor: Importin beta-1 subunit, Snurportin-1
Authors:Mitrousis, G, Cingolani, G.
Deposit date:2007-03-22
Release date:2008-01-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Molecular Basis for the Recognition of Snurportin 1 by Importin {beta}.
J.Biol.Chem., 283, 2008
7DBG
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BU of 7dbg by Molmil
Yeast CRM1e (apo) in complex with Ran-RanBP1
Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, CRM1 isoform 1, ...
Authors:Sun, Q, Lei, Y.
Deposit date:2020-10-20
Release date:2021-09-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin.
J.Nat.Prod., 84, 2021
2Q5D
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BU of 2q5d by Molmil
Crystal Structure of Human Importin Beta bound to the Snurportin1 IBB-domain second crystal form
Descriptor: Importin beta-1 subunit, Snurportin-1
Authors:Mitrousis, G, Cingolani, G.
Deposit date:2007-05-31
Release date:2008-01-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Molecular Basis for the Recognition of Snurportin 1 by Importin {beta}.
J.Biol.Chem., 283, 2008
1O6P
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BU of 1o6p by Molmil
Importin Beta bound to a GLFG Nucleoporin peptide
Descriptor: IMPORTIN BETA-1 SUBUNIT, SYNTHETIC GLFG PEPTIDE
Authors:Bayliss, R, Stewart, M.
Deposit date:2002-10-10
Release date:2003-04-24
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Glfg and Fxfg Nucleoporins Bind to Overlapping Sites on Importin-Beta
J.Biol.Chem., 277, 2002
1O6O
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BU of 1o6o by Molmil
Importin Beta aa1-442 bound to five FxFG repeats from yeast Nsp1p. Second crystal form
Descriptor: IMPORTIN BETA-1 SUBUNIT, NUCLEOPORIN NSP1
Authors:Bayliss, R, Stewart, M.
Deposit date:2002-10-10
Release date:2003-10-17
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Glfg and Fxfg Nucleoporins Bind to Overlapping Sites on Importin-Beta
J.Biol.Chem., 277, 2002
8DYO
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BU of 8dyo by Molmil
Cryo-EM structure of Importin-4 bound to RanGTP
Descriptor: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-4, ...
Authors:Bernardes, N.E, Fung, H.Y.J, Li, Y, Chen, Z, Chook, Y.M.
Deposit date:2022-08-04
Release date:2022-09-21
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex.
Proc.Natl.Acad.Sci.USA, 119, 2022
1QGR
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BU of 1qgr by Molmil
STRUCTURE OF IMPORTIN BETA BOUND TO THE IBB DOMAIN OF IMPORTIN ALPHA (II CRYSTAL FORM, GROWN AT LOW PH)
Descriptor: PROTEIN (IMPORTIN ALPHA-2 SUBUNIT), PROTEIN (IMPORTIN BETA SUBUNIT)
Authors:Cingolani, G, Petosa, C, Weis, K, Muller, C.W.
Deposit date:1999-05-04
Release date:1999-05-24
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of importin-beta bound to the IBB domain of importin-alpha.
Nature, 399, 1999
1QGK
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BU of 1qgk by Molmil
STRUCTURE OF IMPORTIN BETA BOUND TO THE IBB DOMAIN OF IMPORTIN ALPHA
Descriptor: PROTEIN (IMPORTIN ALPHA-2 SUBUNIT), PROTEIN (IMPORTIN BETA SUBUNIT)
Authors:Cingolani, G, Petosa, C, Weis, K, Muller, C.W.
Deposit date:1999-04-29
Release date:1999-05-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of importin-beta bound to the IBB domain of importin-alpha.
Nature, 399, 1999
8F7A
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BU of 8f7a by Molmil
Cryo-EM structure of Importin-9 bound to RanGTP
Descriptor: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-9, ...
Authors:Bernardes, N.E, Chook, Y.M.
Deposit date:2022-11-18
Release date:2023-07-26
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8F0X
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BU of 8f0x by Molmil
Cryo-EM structure of Kap114 bound to H2A-H2B
Descriptor: Histone H2A.2, Histone H2B.2, Importin subunit beta-5
Authors:Jiou, J, Chook, Y.M.
Deposit date:2022-11-04
Release date:2023-07-26
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8F1E
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BU of 8f1e by Molmil
Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP) and H2A-H2B
Descriptor: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Histone H2A.2, ...
Authors:Jiou, J, Chook, Y.M.
Deposit date:2022-11-04
Release date:2023-07-26
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8F19
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BU of 8f19 by Molmil
Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP)
Descriptor: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin subunit beta-5, ...
Authors:Jiou, J, Chook, Y.M.
Deposit date:2022-11-04
Release date:2023-07-26
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
1QBK
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BU of 1qbk by Molmil
STRUCTURE OF THE KARYOPHERIN BETA2-RAN GPPNHP NUCLEAR TRANSPORT COMPLEX
Descriptor: KARYOPHERIN BETA2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Chook, Y.M, Blobel, G.
Deposit date:1999-04-23
Release date:1999-06-01
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp.
Nature, 399, 1999
8HQ3
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BU of 8hq3 by Molmil
KL1 in complex with CRM1-Ran-RanBP1
Descriptor: CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ...
Authors:Sun, Q, Jian, L.
Deposit date:2022-12-13
Release date:2023-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors.
J.Med.Chem., 66, 2023
8HQ6
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BU of 8hq6 by Molmil
KL2 in complex with CRM1-Ran-RanBP1
Descriptor: CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ...
Authors:Sun, Q, Jian, L.
Deposit date:2022-12-13
Release date:2023-10-25
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors.
J.Med.Chem., 66, 2023
8HQ5
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BU of 8hq5 by Molmil
G6 in complex with CRM1-Ran-RanBP1
Descriptor: 3-[(4-bromophenyl)carbonylamino]-4-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]benzoic acid, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ...
Authors:Sun, Q, Lei, Y.
Deposit date:2022-12-13
Release date:2023-12-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:F1 in complex with CRM1-Ran-RanBP1
To Be Published
8HQ4
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BU of 8hq4 by Molmil
B27 in complex with CRM1-Ran-RanBP1
Descriptor: 3-[(4-fluorophenyl)carbonylamino]-4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ...
Authors:Lei, Y, Sun, Q.
Deposit date:2022-12-13
Release date:2023-12-20
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:B27 in complex with CRM1-Ran-RanBP1
To Be Published
8HUF
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BU of 8huf by Molmil
B28 in complex with CRM1-Ran-RanBP1
Descriptor: 3-[(4-chlorophenyl)carbonylamino]-4-[4-(2,5-dimethylphenyl)piperazin-1-yl]benzoic acid, BROMIDE ION, CHLORIDE ION, ...
Authors:Sun, Q, Lei, Y.
Deposit date:2022-12-23
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:B28 in complex with CRM1-Ran-RanBP1
To Be Published
8HUG
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BU of 8hug by Molmil
F1 in complex with CRM1-Ran-RanBP1
Descriptor: 4-[4-(3-chlorophenyl)piperazin-1-yl]-3-[(3-fluorophenyl)sulfonylamino]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ...
Authors:Sun, Q, Lei, Y.
Deposit date:2022-12-23
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:F1 in complex with CRM1-Ran-RanBP1
To Be Published
6M6X
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BU of 6m6x by Molmil
Oridonin in complex with CRM1#-Ran-RanBP1
Descriptor: (1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Sun, Q, Lei, Y.
Deposit date:2020-03-16
Release date:2021-03-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin.
J.Nat.Prod., 84, 2021
6LQ9
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BU of 6lq9 by Molmil
S109 in complex with CRM1-Ran-RanBP1
Descriptor: (3~{R},4~{S})-1-[[6-chloranyl-5-(trifluoromethyl)pyridin-2-yl]amino]-3,4-dimethyl-pyrrolidine-2,5-dione, CHLORIDE ION, Exportin-1, ...
Authors:Sun, Q, Lei, Y.
Deposit date:2020-01-13
Release date:2021-06-23
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-Guided Design of the First Noncovalent Small-Molecule Inhibitor of CRM1.
J.Med.Chem., 64, 2021
6M60
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BU of 6m60 by Molmil
Plumbagin in complex with CRM1#-Ran-RanBP1
Descriptor: (2~{R})-2-methyl-5-oxidanyl-2,3-dihydronaphthalene-1,4-dione, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Sun, Q, Lei, Y.
Deposit date:2020-03-12
Release date:2021-06-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin.
J.Nat.Prod., 84, 2021
6N88
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BU of 6n88 by Molmil
Cryo-EM structure of the Importin7:Importin beta:Histone H1.0 complex
Descriptor: Histone H1.0, Importin subunit beta-1, MGC52556 protein
Authors:Bilokapic, S, Ivic, N, Halic, M.
Deposit date:2018-11-28
Release date:2019-02-27
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:Fuzzy Interactions Form and Shape the Histone Transport Complex.
Mol. Cell, 73, 2019
5DHA
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BU of 5dha by Molmil
Crystal Structure of CPEB4 NES Reverse Mutant Peptide in complex with CRM1-Ran-RanBP1
Descriptor: Engineered Nuclear Export Signal Peptide (CPEB4 NES reverse mutant), Exportin-1, GLYCEROL, ...
Authors:Fung, H.Y, Chook, Y.M.
Deposit date:2015-08-30
Release date:2015-09-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural determinants of nuclear export signal orientation in binding to exportin CRM1.
Elife, 4, 2015

221051

數據於2024-06-12公開中

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