PDB: 2558 resultsInfo pagesStatus searchChemie searchBIRD

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6RMV	The crystal structure of a TRP channel peptide bound to a G protein beta gamma heterodimer Descriptor: GLYCEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Gruss, F, Oberwinkler, J, Ulens, C. Deposit date: 2019-05-07 Release date: 2020-10-14 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.94 Å) Cite: The structural basis for an on-off switch controlling G beta gamma-mediated inhibition of TRPM3 channels. Proc.Natl.Acad.Sci.USA, 117, 2020
8BD7	IFTB1 subcomplex of anterograde Intraflagellar transport trains (Chlamydomonas reinhardtii) Descriptor: Clusterin-associated protein 1, IFT54, IFT70, ... Authors: Lacey, S.E, Foster, H.E, Pigino, G. Deposit date: 2022-10-18 Release date: 2023-01-11 Last modified: 2023-07-26 Method: ELECTRON MICROSCOPY (9.9 Å) Cite: The molecular structure of IFT-A and IFT-B in anterograde intraflagellar transport trains. Nat.Struct.Mol.Biol., 30, 2023
8BDA	IFTA complex in anterograde intraflagellar transport trains (Chlamydomonas reinhardtii) Descriptor: Intraflagellar transport particle protein 140, Intraflagellar transport protein 121, Intraflagellar transport protein 122 homolog, ... Authors: Lacey, S.E, Foster, H.E, Pigino, G. Deposit date: 2022-10-18 Release date: 2023-01-11 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (20.700001 Å) Cite: The molecular structure of IFT-A and IFT-B in anterograde intraflagellar transport trains. Nat.Struct.Mol.Biol., 30, 2023
6RLB	Structure of the dynein-2 complex; tail domain Descriptor: Cytoplasmic dynein 2 light intermediate chain 1, Dynein light chain 1, cytoplasmic, ... Authors: Toropova, K, Zalyte, R, Mukhopadhyay, A.G, Mladenov, M, Carter, A.P, Roberts, A.J. Deposit date: 2019-05-01 Release date: 2019-08-28 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: Structure of the dynein-2 complex and its assembly with intraflagellar transport trains. Nat.Struct.Mol.Biol., 26, 2019
6S29	Structure of fission yeast Mis16-Mis19 complex Descriptor: BROMIDE ION, CENP-A recruiting complex protein mis19, Histone acetyltransferase type B subunit 2 Authors: Lefevre, S, Korntner-Vetter, M, Singleton, M.R. Deposit date: 2019-06-20 Release date: 2019-08-07 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.988 Å) Cite: Subunit interactions and arrangements in the fission yeast Mis16-Mis18-Mis19 complex. Life Sci Alliance, 2, 2019
6SB2	cryo-EM structure of mTORC1 bound to active RagA/C GTPases Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Ras-related GTP-binding protein A, ... Authors: Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. Deposit date: 2019-07-18 Release date: 2019-10-16 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (6.2 Å) Cite: Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
6SC2	Structure of the dynein-2 complex; IFT-train bound model Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 2 light intermediate chain 1, ... Authors: Toropova, K, Zalyte, R, Mukhopadhyay, A.G, Mladenov, M, Carter, A.P, Roberts, A.J. Deposit date: 2019-07-23 Release date: 2019-09-04 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structure of the dynein-2 complex and its assembly with intraflagellar transport trains. Nat.Struct.Mol.Biol., 26, 2019
6SB0	cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Proline-rich AKT1 substrate 1, ... Authors: Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. Deposit date: 2019-07-18 Release date: 2019-10-16 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (5.5 Å) Cite: Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
6T9I	cryo-EM structure of transcription coactivator SAGA Descriptor: Protein SPT3, SAGA-associated factor 73, Transcription factor SPT20, ... Authors: Wang, H, Cheung, A, Cramer, P. Deposit date: 2019-10-28 Release date: 2020-01-29 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structure of the transcription coactivator SAGA. Nature, 577, 2020
6TBL	Crystal structure of MMS19(CTD)-CIAO1-CIAO2B CIA targeting complex Descriptor: 1,2-ETHANEDIOL, MIP18 family protein galla-2, MMS19 nucleotide excision repair protein homolog, ... Authors: Kassube, S.A, Thoma, N.H. Deposit date: 2019-11-01 Release date: 2020-07-29 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structural insights into Fe-S protein biogenesis by the CIA targeting complex. Nat.Struct.Mol.Biol., 27, 2020
6TBN	Crystal structure of CIAO1-CIAO2B CIA core complex Descriptor: MIP18 family protein galla-2, Probable cytosolic iron-sulfur protein assembly protein Ciao1, SODIUM ION Authors: Kassube, S.A, Thoma, N.H. Deposit date: 2019-11-01 Release date: 2020-07-29 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural insights into Fe-S protein biogenesis by the CIA targeting complex. Nat.Struct.Mol.Biol., 27, 2020
6TC0	Crystal structure of MMS19-CIAO1-CIAO2B CIA targeting complex Descriptor: MIP18 family protein galla-2, MMS19 nucleotide excision repair protein homolog, Probable cytosolic iron-sulfur protein assembly protein Ciao1 Authors: Kassube, S.A, Thoma, N.H. Deposit date: 2019-11-04 Release date: 2020-07-29 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structural insights into Fe-S protein biogenesis by the CIA targeting complex. Nat.Struct.Mol.Biol., 27, 2020
6U4Y	Crystal Structure of an EZH2-EED Complex in an Oligomeric State Descriptor: Histone-lysine N-methyltransferase EZH2, Polycomb protein EED Authors: Jiao, L, Liu, X. Deposit date: 2019-08-26 Release date: 2020-07-08 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.91 Å) Cite: A partially disordered region connects gene repression and activation functions of EZH2. Proc.Natl.Acad.Sci.USA, 117, 2020
6U62	Raptor-Rag-Ragulator complex Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Rogala, K.B, Sabatini, D.M. Deposit date: 2019-08-29 Release date: 2019-10-30 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: Structural basis for the docking of mTORC1 on the lysosomal surface. Science, 366, 2019
6TED	Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers allosteric elongation activation by RTF1 Descriptor: DNA (37-MER), DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerase subunit, ... Authors: Vos, S.M, Farnung, L, Cramer, P. Deposit date: 2019-11-11 Release date: 2020-07-22 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex reveals RTF1 allosteric activation. Nat.Struct.Mol.Biol., 27, 2020
6T9K	SAGA Core module Descriptor: Protein SPT3, SAGA-associated factor 73, Transcription factor SPT20, ... Authors: Wang, H, Cheung, A, Cramer, P. Deposit date: 2019-10-28 Release date: 2020-01-29 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structure of the transcription coactivator SAGA. Nature, 577, 2020
6V0N	PRMT5 bound to PBM peptide from Riok1 Descriptor: Methylosome protein 50, Protein arginine N-methyltransferase 5, Riok1 PBM peptide, ... Authors: McMIllan, B.J, Raymond, D.D. Deposit date: 2019-11-19 Release date: 2020-08-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Molecular basis for substrate recruitment to the PRMT5 methylosome. Mol.Cell, 81, 2021
6TLJ	Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Mitotic checkpoint complex (APC/C-MCC) at 3.8 angstrom resolution Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... Authors: Alfieri, C, Barford, D. Deposit date: 2019-12-02 Release date: 2020-02-19 Last modified: 2020-06-17 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase. Embo Rep., 21, 2020
6V4U	Cryo-EM structure of SMCR8-C9orf72-WDR41 complex Descriptor: Guanine nucleotide exchange C9orf72, Guanine nucleotide exchange protein SMCR8, WD repeat-containing protein 41 Authors: Su, M.Y, Hurley, J.H. Deposit date: 2019-12-01 Release date: 2020-09-02 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD. Nature, 585, 2020
6UGH	Cryo-EM structure of the apo form of human PRMT5:MEP50 complex at a resolution of 3.4 angstrom Descriptor: Methylosome protein 50, Protein arginine N-methyltransferase 5 Authors: Zhou, W, Yadav, G.P, Jiang, Q.-X, Li, C. Deposit date: 2019-09-26 Release date: 2020-12-09 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: A 3.4-angstrom cryo-EM structure of the apo form of hu-man PRMT5:MEP50 complex reveals sequential catalysis of symmetric methyl transfer To Be Published
6UXY	PRMT5:MEP50 Complexed with Allosteric Inhibitor Compound 8 Descriptor: (5R)-2-amino-5-(2-cyclohexylethyl)-3-methyl-5-phenyl-3,5-dihydro-4H-imidazol-4-one, 1,2-ETHANEDIOL, GLYCEROL, ... Authors: Palte, R.L, Schneider, S.E. Deposit date: 2019-11-08 Release date: 2020-08-19 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.57 Å) Cite: Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5). Acs Med.Chem.Lett., 11, 2020
6V0O	PRMT5 bound to the PBM peptide from pICln Descriptor: ACETYL GROUP, Methylosome protein 50, PBM peptide, ... Authors: McMillan, B.J, Raymond, D.D. Deposit date: 2019-11-19 Release date: 2020-08-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.86 Å) Cite: Molecular basis for substrate recruitment to the PRMT5 methylosome. Mol.Cell, 81, 2021
6UXX	PRMT5:MEP50 Complexed with Allosteric Inhibitor Compound 1a Descriptor: (5R)-2-amino-5-(4-methoxyphenyl)-3-methyl-5-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-yl]-3,5-dihydro-4H-imidazol-4-one, Methylosome protein 50, Protein arginine N-methyltransferase 5 Authors: Palte, R.L, Schneider, S.E. Deposit date: 2019-11-08 Release date: 2020-08-19 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5). Acs Med.Chem.Lett., 11, 2020
6V0P	PRMT5 complex bound to covalent PBM inhibitor BRD6711 Descriptor: 2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-sulfamoylphenyl)acetamide, CHLORIDE ION, GLYCEROL, ... Authors: McMillan, B.J, McKinney, D.C. Deposit date: 2019-11-19 Release date: 2020-11-25 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction. J.Med.Chem., 64, 2021
6YLE	Rix1-Rea1 pre-60S particle - Rix1-subcomplex, body 3 (rigid body refinement) Descriptor: Pre-rRNA-processing protein IPI1, Pre-rRNA-processing protein IPI3, Pre-rRNA-processing protein RIX1 Authors: Kater, L, Beckmann, R. Deposit date: 2020-04-07 Release date: 2020-07-29 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Construction of the Central Protuberance and L1 Stalk during 60S Subunit Biogenesis. Mol.Cell, 79, 2020

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