6SB2

cryo-EM structure of mTORC1 bound to active RagA/C GTPases

Summary for 6SB2

• Entry DOI: 10.2210/pdb6sb2/pdb
• EMDB information: 10132 10133
• Descriptor: mTOR,Serine/threonine-protein kinase mTOR,mTOR,Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Ras-related GTP-binding protein A, ... (7 entities in total)
• Functional Keywords: small gtpases, mtorc1 activator, roadblock domain, gtpase domain, signaling protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 10
• Total formula weight: 1108393.40

Authors

Anandapadamanaban, M.,Berndt, A.,Masson, G.R.,Perisic, O.,Williams, R.L. (deposition date: 2019-07-18, release date: 2019-10-16, Last modification date: 2019-10-23)

• Primary citation: Anandapadamanaban, M.,Masson, G.R.,Perisic, O.,Berndt, A.,Kaufman, J.,Johnson, C.M.,Santhanam, B.,Rogala, K.B.,Sabatini, D.M.,Williams, R.L.; Architecture of human Rag GTPase heterodimers and their complex with mTORC1.; Science, 366:203-210, 2019; PubMed: 31601764; DOI: 10.1126/science.aax3939

Experimental method

ELECTRON MICROSCOPY (6.2 Å)