Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6SB2

cryo-EM structure of mTORC1 bound to active RagA/C GTPases

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000166	molecular_function	nucleotide binding
A	0000822	molecular_function	inositol hexakisphosphate binding
A	0001002	molecular_function	RNA polymerase III type 1 promoter sequence-specific DNA binding
A	0001003	molecular_function	RNA polymerase III type 2 promoter sequence-specific DNA binding
A	0001006	molecular_function	RNA polymerase III type 3 promoter sequence-specific DNA binding
A	0001156	molecular_function	TFIIIC-class transcription factor complex binding
A	0001558	biological_process	regulation of cell growth
A	0002296	biological_process	T-helper 1 cell lineage commitment
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005741	cellular_component	mitochondrial outer membrane
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006468	biological_process	protein phosphorylation
A	0006954	biological_process	inflammatory response
A	0006974	biological_process	DNA damage response
A	0007010	biological_process	cytoskeleton organization
A	0008361	biological_process	regulation of cell size
A	0009267	biological_process	cellular response to starvation
A	0009408	biological_process	response to heat
A	0009891	biological_process	positive regulation of biosynthetic process
A	0010506	biological_process	regulation of autophagy
A	0010507	biological_process	negative regulation of autophagy
A	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
A	0012505	cellular_component	endomembrane system
A	0016020	cellular_component	membrane
A	0016241	biological_process	regulation of macroautophagy
A	0016242	biological_process	negative regulation of macroautophagy
A	0016301	molecular_function	kinase activity
A	0016605	cellular_component	PML body
A	0016740	molecular_function	transferase activity
A	0019216	biological_process	regulation of lipid metabolic process
A	0019228	biological_process	neuronal action potential
A	0030307	biological_process	positive regulation of cell growth
A	0030425	cellular_component	dendrite
A	0031295	biological_process	T cell costimulation
A	0031410	cellular_component	cytoplasmic vesicle
A	0031667	biological_process	response to nutrient levels
A	0031669	biological_process	cellular response to nutrient levels
A	0031670	biological_process	cellular response to nutrient
A	0031929	biological_process	TOR signaling
A	0031931	cellular_component	TORC1 complex
A	0031932	cellular_component	TORC2 complex
A	0032869	biological_process	cellular response to insulin stimulus
A	0032956	biological_process	regulation of actin cytoskeleton organization
A	0034198	biological_process	cellular response to amino acid starvation
A	0038202	biological_process	TORC1 signaling
A	0038203	biological_process	TORC2 signaling
A	0042752	biological_process	regulation of circadian rhythm
A	0042802	molecular_function	identical protein binding
A	0043022	molecular_function	ribosome binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0043200	biological_process	response to amino acid
A	0043276	biological_process	anoikis
A	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0044325	molecular_function	transmembrane transporter binding
A	0044877	molecular_function	protein-containing complex binding
A	0045335	cellular_component	phagocytic vesicle
A	0045597	biological_process	positive regulation of cell differentiation
A	0045670	biological_process	regulation of osteoclast differentiation
A	0045727	biological_process	positive regulation of translation
A	0045821	biological_process	positive regulation of glycolytic process
A	0045860	biological_process	positive regulation of protein kinase activity
A	0045945	biological_process	positive regulation of transcription by RNA polymerase III
A	0045948	biological_process	positive regulation of translational initiation
A	0046627	biological_process	negative regulation of insulin receptor signaling pathway
A	0046889	biological_process	positive regulation of lipid biosynthetic process
A	0048266	biological_process	behavioral response to pain
A	0050821	biological_process	protein stabilization
A	0051219	molecular_function	phosphoprotein binding
A	0051240	biological_process	positive regulation of multicellular organismal process
A	0051549	biological_process	positive regulation of keratinocyte migration
A	0051896	biological_process	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0055006	biological_process	cardiac cell development
A	0061431	biological_process	cellular response to methionine
A	0062027	biological_process	positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process
A	0071230	biological_process	cellular response to amino acid stimulus
A	0071233	biological_process	cellular response to L-leucine
A	0071456	biological_process	cellular response to hypoxia
A	0071470	biological_process	cellular response to osmotic stress
A	0080135	biological_process	regulation of cellular response to stress
A	0097700	biological_process	vascular endothelial cell response to laminar fluid shear stress
A	0106310	molecular_function	protein serine kinase activity
A	1900034	biological_process	regulation of cellular response to heat
A	1900181	biological_process	negative regulation of protein localization to nucleus
A	1901796	biological_process	regulation of signal transduction by p53 class mediator
A	1901838	biological_process	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
A	1903691	biological_process	positive regulation of wound healing, spreading of epidermal cells
A	1904059	biological_process	regulation of locomotor rhythm
A	1904690	biological_process	positive regulation of cytoplasmic translational initiation
A	1905671	biological_process	regulation of lysosome organization
A	1905672	biological_process	negative regulation of lysosome organization
A	1905857	biological_process	positive regulation of pentose-phosphate shunt
A	1990253	biological_process	cellular response to leucine starvation
A	2000060	biological_process	positive regulation of ubiquitin-dependent protein catabolic process
A	2000785	biological_process	regulation of autophagosome assembly
B	0000139	cellular_component	Golgi membrane
B	0000166	molecular_function	nucleotide binding
B	0000822	molecular_function	inositol hexakisphosphate binding
B	0001002	molecular_function	RNA polymerase III type 1 promoter sequence-specific DNA binding
B	0001003	molecular_function	RNA polymerase III type 2 promoter sequence-specific DNA binding
B	0001006	molecular_function	RNA polymerase III type 3 promoter sequence-specific DNA binding
B	0001156	molecular_function	TFIIIC-class transcription factor complex binding
B	0001558	biological_process	regulation of cell growth
B	0002296	biological_process	T-helper 1 cell lineage commitment
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005635	cellular_component	nuclear envelope
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005741	cellular_component	mitochondrial outer membrane
B	0005764	cellular_component	lysosome
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006468	biological_process	protein phosphorylation
B	0006954	biological_process	inflammatory response
B	0006974	biological_process	DNA damage response
B	0007010	biological_process	cytoskeleton organization
B	0008361	biological_process	regulation of cell size
B	0009267	biological_process	cellular response to starvation
B	0009408	biological_process	response to heat
B	0009891	biological_process	positive regulation of biosynthetic process
B	0010506	biological_process	regulation of autophagy
B	0010507	biological_process	negative regulation of autophagy
B	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
B	0012505	cellular_component	endomembrane system
B	0016020	cellular_component	membrane
B	0016241	biological_process	regulation of macroautophagy
B	0016242	biological_process	negative regulation of macroautophagy
B	0016301	molecular_function	kinase activity
B	0016605	cellular_component	PML body
B	0016740	molecular_function	transferase activity
B	0019216	biological_process	regulation of lipid metabolic process
B	0019228	biological_process	neuronal action potential
B	0030307	biological_process	positive regulation of cell growth
B	0030425	cellular_component	dendrite
B	0031295	biological_process	T cell costimulation
B	0031410	cellular_component	cytoplasmic vesicle
B	0031667	biological_process	response to nutrient levels
B	0031669	biological_process	cellular response to nutrient levels
B	0031670	biological_process	cellular response to nutrient
B	0031929	biological_process	TOR signaling
B	0031931	cellular_component	TORC1 complex
B	0031932	cellular_component	TORC2 complex
B	0032869	biological_process	cellular response to insulin stimulus
B	0032956	biological_process	regulation of actin cytoskeleton organization
B	0034198	biological_process	cellular response to amino acid starvation
B	0038202	biological_process	TORC1 signaling
B	0038203	biological_process	TORC2 signaling
B	0042752	biological_process	regulation of circadian rhythm
B	0042802	molecular_function	identical protein binding
B	0043022	molecular_function	ribosome binding
B	0043066	biological_process	negative regulation of apoptotic process
B	0043200	biological_process	response to amino acid
B	0043276	biological_process	anoikis
B	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
B	0044325	molecular_function	transmembrane transporter binding
B	0044877	molecular_function	protein-containing complex binding
B	0045335	cellular_component	phagocytic vesicle
B	0045597	biological_process	positive regulation of cell differentiation
B	0045670	biological_process	regulation of osteoclast differentiation
B	0045727	biological_process	positive regulation of translation
B	0045821	biological_process	positive regulation of glycolytic process
B	0045860	biological_process	positive regulation of protein kinase activity
B	0045945	biological_process	positive regulation of transcription by RNA polymerase III
B	0045948	biological_process	positive regulation of translational initiation
B	0046627	biological_process	negative regulation of insulin receptor signaling pathway
B	0046889	biological_process	positive regulation of lipid biosynthetic process
B	0048266	biological_process	behavioral response to pain
B	0050821	biological_process	protein stabilization
B	0051219	molecular_function	phosphoprotein binding
B	0051240	biological_process	positive regulation of multicellular organismal process
B	0051549	biological_process	positive regulation of keratinocyte migration
B	0051896	biological_process	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B	0055006	biological_process	cardiac cell development
B	0061431	biological_process	cellular response to methionine
B	0062027	biological_process	positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process
B	0071230	biological_process	cellular response to amino acid stimulus
B	0071233	biological_process	cellular response to L-leucine
B	0071456	biological_process	cellular response to hypoxia
B	0071470	biological_process	cellular response to osmotic stress
B	0080135	biological_process	regulation of cellular response to stress
B	0097700	biological_process	vascular endothelial cell response to laminar fluid shear stress
B	0106310	molecular_function	protein serine kinase activity
B	1900034	biological_process	regulation of cellular response to heat
B	1900181	biological_process	negative regulation of protein localization to nucleus
B	1901796	biological_process	regulation of signal transduction by p53 class mediator
B	1901838	biological_process	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
B	1903691	biological_process	positive regulation of wound healing, spreading of epidermal cells
B	1904059	biological_process	regulation of locomotor rhythm
B	1904690	biological_process	positive regulation of cytoplasmic translational initiation
B	1905671	biological_process	regulation of lysosome organization
B	1905672	biological_process	negative regulation of lysosome organization
B	1905857	biological_process	positive regulation of pentose-phosphate shunt
B	1990253	biological_process	cellular response to leucine starvation
B	2000060	biological_process	positive regulation of ubiquitin-dependent protein catabolic process
B	2000785	biological_process	regulation of autophagosome assembly
C	0000166	molecular_function	nucleotide binding
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005765	cellular_component	lysosomal membrane
C	0005829	cellular_component	cytosol
C	0006915	biological_process	apoptotic process
C	0008104	biological_process	intracellular protein localization
C	0009267	biological_process	cellular response to starvation
C	0010507	biological_process	negative regulation of autophagy
C	0016787	molecular_function	hydrolase activity
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0031669	biological_process	cellular response to nutrient levels
C	0032008	biological_process	positive regulation of TOR signaling
C	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
C	0034198	biological_process	cellular response to amino acid starvation
C	0035556	biological_process	intracellular signal transduction
C	0042593	biological_process	glucose homeostasis
C	0042803	molecular_function	protein homodimerization activity
C	0043495	molecular_function	protein-membrane adaptor activity
C	0046982	molecular_function	protein heterodimerization activity
C	0051219	molecular_function	phosphoprotein binding
C	0061462	biological_process	protein localization to lysosome
C	0071230	biological_process	cellular response to amino acid stimulus
C	0072657	biological_process	protein localization to membrane
C	1904263	biological_process	positive regulation of TORC1 signaling
C	1990130	cellular_component	GATOR1 complex
C	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
C	1990877	cellular_component	FNIP-folliculin RagC/D GAP
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0003924	molecular_function	GTPase activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005765	cellular_component	lysosomal membrane
D	0005829	cellular_component	cytosol
D	0006351	biological_process	DNA-templated transcription
D	0006915	biological_process	apoptotic process
D	0007264	biological_process	small GTPase-mediated signal transduction
D	0008104	biological_process	intracellular protein localization
D	0008380	biological_process	RNA splicing
D	0009267	biological_process	cellular response to starvation
D	0010507	biological_process	negative regulation of autophagy
D	0016787	molecular_function	hydrolase activity
D	0019003	molecular_function	GDP binding
D	0031669	biological_process	cellular response to nutrient levels
D	0032006	biological_process	regulation of TOR signaling
D	0034198	biological_process	cellular response to amino acid starvation
D	0043200	biological_process	response to amino acid
D	0043495	molecular_function	protein-membrane adaptor activity
D	0046982	molecular_function	protein heterodimerization activity
D	0051020	molecular_function	GTPase binding
D	0060090	molecular_function	molecular adaptor activity
D	0061462	biological_process	protein localization to lysosome
D	0071230	biological_process	cellular response to amino acid stimulus
D	0072657	biological_process	protein localization to membrane
D	0140767	molecular_function	enzyme-substrate adaptor activity
D	1903432	biological_process	regulation of TORC1 signaling
D	1904263	biological_process	positive regulation of TORC1 signaling
D	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
D	1990877	cellular_component	FNIP-folliculin RagC/D GAP
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0005515	molecular_function	protein binding
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005765	cellular_component	lysosomal membrane
E	0005829	cellular_component	cytosol
E	0006974	biological_process	DNA damage response
E	0007010	biological_process	cytoskeleton organization
E	0010507	biological_process	negative regulation of autophagy
E	0030307	biological_process	positive regulation of cell growth
E	0030674	molecular_function	protein-macromolecule adaptor activity
E	0031669	biological_process	cellular response to nutrient levels
E	0031929	biological_process	TOR signaling
E	0031931	cellular_component	TORC1 complex
E	0031932	cellular_component	TORC2 complex
E	0032008	biological_process	positive regulation of TOR signaling
E	0032956	biological_process	regulation of actin cytoskeleton organization
E	0038202	biological_process	TORC1 signaling
E	0038203	biological_process	TORC2 signaling
E	0043066	biological_process	negative regulation of apoptotic process
E	0043539	molecular_function	protein serine/threonine kinase activator activity
E	0045821	biological_process	positive regulation of glycolytic process
E	0046889	biological_process	positive regulation of lipid biosynthetic process
E	0071456	biological_process	cellular response to hypoxia
E	0071470	biological_process	cellular response to osmotic stress
E	1905857	biological_process	positive regulation of pentose-phosphate shunt
H	0004674	molecular_function	protein serine/threonine kinase activity
H	0005515	molecular_function	protein binding
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005765	cellular_component	lysosomal membrane
H	0005829	cellular_component	cytosol
H	0006974	biological_process	DNA damage response
H	0007010	biological_process	cytoskeleton organization
H	0010507	biological_process	negative regulation of autophagy
H	0030307	biological_process	positive regulation of cell growth
H	0030674	molecular_function	protein-macromolecule adaptor activity
H	0031669	biological_process	cellular response to nutrient levels
H	0031929	biological_process	TOR signaling
H	0031931	cellular_component	TORC1 complex
H	0031932	cellular_component	TORC2 complex
H	0032008	biological_process	positive regulation of TOR signaling
H	0032956	biological_process	regulation of actin cytoskeleton organization
H	0038202	biological_process	TORC1 signaling
H	0038203	biological_process	TORC2 signaling
H	0043066	biological_process	negative regulation of apoptotic process
H	0043539	molecular_function	protein serine/threonine kinase activator activity
H	0045821	biological_process	positive regulation of glycolytic process
H	0046889	biological_process	positive regulation of lipid biosynthetic process
H	0071456	biological_process	cellular response to hypoxia
H	0071470	biological_process	cellular response to osmotic stress
H	1905857	biological_process	positive regulation of pentose-phosphate shunt
I	0000166	molecular_function	nucleotide binding
I	0003924	molecular_function	GTPase activity
I	0005515	molecular_function	protein binding
I	0005525	molecular_function	GTP binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005764	cellular_component	lysosome
I	0005765	cellular_component	lysosomal membrane
I	0005829	cellular_component	cytosol
I	0006915	biological_process	apoptotic process
I	0008104	biological_process	intracellular protein localization
I	0009267	biological_process	cellular response to starvation
I	0010507	biological_process	negative regulation of autophagy
I	0016787	molecular_function	hydrolase activity
I	0031625	molecular_function	ubiquitin protein ligase binding
I	0031669	biological_process	cellular response to nutrient levels
I	0032008	biological_process	positive regulation of TOR signaling
I	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
I	0034198	biological_process	cellular response to amino acid starvation
I	0035556	biological_process	intracellular signal transduction
I	0042593	biological_process	glucose homeostasis
I	0042803	molecular_function	protein homodimerization activity
I	0043495	molecular_function	protein-membrane adaptor activity
I	0046982	molecular_function	protein heterodimerization activity
I	0051219	molecular_function	phosphoprotein binding
I	0061462	biological_process	protein localization to lysosome
I	0071230	biological_process	cellular response to amino acid stimulus
I	0072657	biological_process	protein localization to membrane
I	1904263	biological_process	positive regulation of TORC1 signaling
I	1990130	cellular_component	GATOR1 complex
I	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
I	1990877	cellular_component	FNIP-folliculin RagC/D GAP
J	0000166	molecular_function	nucleotide binding
J	0000287	molecular_function	magnesium ion binding
J	0003924	molecular_function	GTPase activity
J	0005515	molecular_function	protein binding
J	0005525	molecular_function	GTP binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005764	cellular_component	lysosome
J	0005765	cellular_component	lysosomal membrane
J	0005829	cellular_component	cytosol
J	0006351	biological_process	DNA-templated transcription
J	0006915	biological_process	apoptotic process
J	0007264	biological_process	small GTPase-mediated signal transduction
J	0008104	biological_process	intracellular protein localization
J	0008380	biological_process	RNA splicing
J	0009267	biological_process	cellular response to starvation
J	0010507	biological_process	negative regulation of autophagy
J	0016787	molecular_function	hydrolase activity
J	0019003	molecular_function	GDP binding
J	0031669	biological_process	cellular response to nutrient levels
J	0032006	biological_process	regulation of TOR signaling
J	0034198	biological_process	cellular response to amino acid starvation
J	0043200	biological_process	response to amino acid
J	0043495	molecular_function	protein-membrane adaptor activity
J	0046982	molecular_function	protein heterodimerization activity
J	0051020	molecular_function	GTPase binding
J	0060090	molecular_function	molecular adaptor activity
J	0061462	biological_process	protein localization to lysosome
J	0071230	biological_process	cellular response to amino acid stimulus
J	0072657	biological_process	protein localization to membrane
J	0140767	molecular_function	enzyme-substrate adaptor activity
J	1903432	biological_process	regulation of TORC1 signaling
J	1904263	biological_process	positive regulation of TORC1 signaling
J	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
J	1990877	cellular_component	FNIP-folliculin RagC/D GAP
N	0001558	biological_process	regulation of cell growth
N	0001938	biological_process	positive regulation of endothelial cell proliferation
N	0004674	molecular_function	protein serine/threonine kinase activity
N	0005515	molecular_function	protein binding
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005764	cellular_component	lysosome
N	0005765	cellular_component	lysosomal membrane
N	0005829	cellular_component	cytosol
N	0006974	biological_process	DNA damage response
N	0008361	biological_process	regulation of cell size
N	0009267	biological_process	cellular response to starvation
N	0009410	biological_process	response to xenobiotic stimulus
N	0010494	cellular_component	cytoplasmic stress granule
N	0010506	biological_process	regulation of autophagy
N	0010507	biological_process	negative regulation of autophagy
N	0010646	biological_process	regulation of cell communication
N	0019901	molecular_function	protein kinase binding
N	0023051	biological_process	regulation of signaling
N	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
N	0030295	molecular_function	protein kinase activator activity
N	0030307	biological_process	positive regulation of cell growth
N	0030425	cellular_component	dendrite
N	0030674	molecular_function	protein-macromolecule adaptor activity
N	0031267	molecular_function	small GTPase binding
N	0031669	biological_process	cellular response to nutrient levels
N	0031929	biological_process	TOR signaling
N	0031931	cellular_component	TORC1 complex
N	0032008	biological_process	positive regulation of TOR signaling
N	0035176	biological_process	social behavior
N	0038202	biological_process	TORC1 signaling
N	0043025	cellular_component	neuronal cell body
N	0044877	molecular_function	protein-containing complex binding
N	0045672	biological_process	positive regulation of osteoclast differentiation
N	0045821	biological_process	positive regulation of glycolytic process
N	0045945	biological_process	positive regulation of transcription by RNA polymerase III
N	0046889	biological_process	positive regulation of lipid biosynthetic process
N	0060255	biological_process	regulation of macromolecule metabolic process
N	0071230	biological_process	cellular response to amino acid stimulus
N	0071233	biological_process	cellular response to L-leucine
N	0071333	biological_process	cellular response to glucose stimulus
N	0071456	biological_process	cellular response to hypoxia
N	0071470	biological_process	cellular response to osmotic stress
N	0071889	molecular_function	14-3-3 protein binding
N	0080090	biological_process	regulation of primary metabolic process
N	0140767	molecular_function	enzyme-substrate adaptor activity
N	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
N	1901331	biological_process	positive regulation of odontoblast differentiation
N	1905857	biological_process	positive regulation of pentose-phosphate shunt
Y	0001558	biological_process	regulation of cell growth
Y	0001938	biological_process	positive regulation of endothelial cell proliferation
Y	0004674	molecular_function	protein serine/threonine kinase activity
Y	0005515	molecular_function	protein binding
Y	0005654	cellular_component	nucleoplasm
Y	0005737	cellular_component	cytoplasm
Y	0005764	cellular_component	lysosome
Y	0005765	cellular_component	lysosomal membrane
Y	0005829	cellular_component	cytosol
Y	0006974	biological_process	DNA damage response
Y	0008361	biological_process	regulation of cell size
Y	0009267	biological_process	cellular response to starvation
Y	0009410	biological_process	response to xenobiotic stimulus
Y	0010494	cellular_component	cytoplasmic stress granule
Y	0010506	biological_process	regulation of autophagy
Y	0010507	biological_process	negative regulation of autophagy
Y	0010646	biological_process	regulation of cell communication
Y	0019901	molecular_function	protein kinase binding
Y	0023051	biological_process	regulation of signaling
Y	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
Y	0030295	molecular_function	protein kinase activator activity
Y	0030307	biological_process	positive regulation of cell growth
Y	0030425	cellular_component	dendrite
Y	0030674	molecular_function	protein-macromolecule adaptor activity
Y	0031267	molecular_function	small GTPase binding
Y	0031669	biological_process	cellular response to nutrient levels
Y	0031929	biological_process	TOR signaling
Y	0031931	cellular_component	TORC1 complex
Y	0032008	biological_process	positive regulation of TOR signaling
Y	0035176	biological_process	social behavior
Y	0038202	biological_process	TORC1 signaling
Y	0043025	cellular_component	neuronal cell body
Y	0044877	molecular_function	protein-containing complex binding
Y	0045672	biological_process	positive regulation of osteoclast differentiation
Y	0045821	biological_process	positive regulation of glycolytic process
Y	0045945	biological_process	positive regulation of transcription by RNA polymerase III
Y	0046889	biological_process	positive regulation of lipid biosynthetic process
Y	0060255	biological_process	regulation of macromolecule metabolic process
Y	0071230	biological_process	cellular response to amino acid stimulus
Y	0071233	biological_process	cellular response to L-leucine
Y	0071333	biological_process	cellular response to glucose stimulus
Y	0071456	biological_process	cellular response to hypoxia
Y	0071470	biological_process	cellular response to osmotic stress
Y	0071889	molecular_function	14-3-3 protein binding
Y	0080090	biological_process	regulation of primary metabolic process
Y	0140767	molecular_function	enzyme-substrate adaptor activity
Y	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
Y	1901331	biological_process	positive regulation of odontoblast differentiation
Y	1905857	biological_process	positive regulation of pentose-phosphate shunt

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue GTP C 401

Chain	Residue
C	GLY17
C	GLY40
C	ALA41
C	THR42
C	GLY64
C	GLY65
C	SER163
C	ILE164
C	SER18
C	GLY19
C	LYS20
C	THR21
C	SER22
C	THR36
C	ARG37
C	LEU39

site_id	AC2
Number of Residues	7
Details	binding site for residue GDP D 401

Chain	Residue
D	ARG71
D	SER72
D	GLY73
D	LYS74
D	SER75
D	SER76
D	ILE220

site_id	AC3
Number of Residues	16
Details	binding site for residue GTP I 401

Chain	Residue
I	GLY17
I	SER18
I	GLY19
I	LYS20
I	THR21
I	SER22
I	THR36
I	ARG37
I	LEU39
I	GLY40
I	ALA41
I	THR42
I	GLY64
I	GLY65
I	SER163
I	ILE164

site_id	AC4
Number of Residues	7
Details	binding site for residue GDP J 401

Chain	Residue
J	ARG71
J	SER72
J	GLY73
J	LYS74
J	SER75
J	SER76
J	ILE220

Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. KAYkVnpDmNFEvFIHKV

Chain	Residue	Details
D	LYS163-VAL180

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. LKgh.EDLRQDervmQ

Chain	Residue	Details
A	LEU2186-GLN2200

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SlAvmsMvgYILgLgDRHpsN

Chain	Residue	Details
A	SER2323-ASN2343

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. MYTGgeDcTARIWDL

Chain	Residue	Details
E	MET100-LEU114

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	Repeat: {"description":"HEAT 10"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	68
Details	Repeat: {"description":"HEAT 12"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	66
Details	Repeat: {"description":"HEAT 13"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	92
Details	Repeat: {"description":"HEAT 16"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	76
Details	Repeat: {"description":"HEAT 17"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	78
Details	Repeat: {"description":"HEAT 18"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	84
Details	Repeat: {"description":"HEAT 19"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	78
Details	Repeat: {"description":"HEAT 20"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	72
Details	Repeat: {"description":"HEAT 21"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	76
Details	Repeat: {"description":"HEAT 24"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	78
Details	Repeat: {"description":"HEAT 25"}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	72
Details	Repeat: {"description":"HEAT 26"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	76
Details	Repeat: {"description":"HEAT 27"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	86
Details	Repeat: {"description":"HEAT 28"}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	72
Details	Repeat: {"description":"HEAT 29"}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	94
Details	Repeat: {"description":"HEAT 30"}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	74
Details	Repeat: {"description":"HEAT 31"}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	66
Details	Repeat: {"description":"HEAT 32"}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	72
Details	Repeat: {"description":"TPR 1"}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	50
Details	Repeat: {"description":"TPR 2"}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	66
Details	Repeat: {"description":"TPR 3"}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	60
Details	Repeat: {"description":"TPR 4"}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	78
Details	Repeat: {"description":"TPR 8"}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	68
Details	Repeat: {"description":"TPR 9"}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	86
Details	Repeat: {"description":"TPR 10"}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	74
Details	Repeat: {"description":"TPR 11"}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	108
Details	Repeat: {"description":"TPR 12"}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	118
Details	Repeat: {"description":"TPR 13"}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	64
Details	Repeat: {"description":"TPR 14"}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	78
Details	Repeat: {"description":"TPR 15"}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	68
Details	Repeat: {"description":"TPR 16"}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	110
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	80
Details	Compositional bias: {"description":"Low complexity","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33158864","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ZWM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29236692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BCU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BCX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29236692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BCX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19487463","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI41
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"37979583","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI42
Number of Residues	80
Details	Repeat: {"description":"WD 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23636326","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI43
Number of Residues	78
Details	Repeat: {"description":"WD 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23636326","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI44
Number of Residues	78
Details	Repeat: {"description":"WD 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23636326","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI45
Number of Residues	78
Details	Repeat: {"description":"WD 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23636326","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI46
Number of Residues	78
Details	Repeat: {"description":"WD 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23636326","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI47
Number of Residues	82
Details	Repeat: {"description":"WD 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23636326","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI48
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by CDK1","evidences":[{"source":"PubMed","id":"34741373","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI49
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3)","evidences":[{"source":"PubMed","id":"38395307","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI50
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"28489822","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI51
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI52
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36103527","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DHB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI53
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI54
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI55
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI56
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31672913","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31704029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ULG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI57
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31704029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ULG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI58
Number of Residues	10
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"25936802","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI59
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI60
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI61
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI62
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI63
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI64
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI65
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI66
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI67
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI68
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI69
Number of Residues	82
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI70
Number of Residues	82
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI71
Number of Residues	78
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI72
Number of Residues	80
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI73
Number of Residues	80
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI74
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"31530866","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI75
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"30197302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32561715","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)