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7CEG
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BU of 7ceg by Molmil
Crystal structure of the complex between mouse PTP delta and neuroligin-3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform C of Receptor-type tyrosine-protein phosphatase delta, Neuroligin-3
Authors:Yamagata, A, Yoshida, T, Shiroshima, T, Maeda, A, Fukai, S.
Deposit date:2020-06-23
Release date:2021-02-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.85 Å)
Cite:Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice.
Nat Commun, 12, 2021
6MOE
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BU of 6moe by Molmil
Monomeric DARPin E2 complex with EpoR
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E2 DARPin, ...
Authors:Jude, K.M, Mohan, K, Garcia, K.C.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.091 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6POG
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BU of 6pog by Molmil
Crystal structure of the NELL2 EGF1-6-Robo3 FN1 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Wang, J, Pak, J.S, Ozkan, E.
Deposit date:2019-07-03
Release date:2020-05-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.755 Å)
Cite:NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance.
Nat Commun, 11, 2020
6MOL
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BU of 6mol by Molmil
Monoextended DARPin M_R12 complex with EpoR
Descriptor: Erythropoietin receptor, GLYCEROL, Monoextended DARPin R12 (M_R12)
Authors:Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.163 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOF
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BU of 6mof by Molmil
Monomeric DARPin G2 complex with EpoR
Descriptor: 1,2-ETHANEDIOL, Erythropoietin receptor, G2 DARPin
Authors:Jude, K.M, Mohan, K, Garcia, K.C.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.894 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6PXV
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BU of 6pxv by Molmil
Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the extracellular region.
Descriptor: Insulin, Insulin receptor
Authors:Uchikawa, E, Choi, E, Shang, G.J, Yu, H.T, Bai, X.C.
Deposit date:2019-07-27
Release date:2019-09-04
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex.
Elife, 8, 2019
1A22
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BU of 1a22 by Molmil
HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR
Descriptor: GROWTH HORMONE, GROWTH HORMONE RECEPTOR
Authors:De Vos, A.M, Ultsch, M.
Deposit date:1998-01-15
Release date:1998-04-29
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.
J.Mol.Biol., 277, 1998
6NAJ
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BU of 6naj by Molmil
Integrin AlphaVBeta3 ectodomain bound to Hr10 variant of the 10th domain of Fibronectin.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ...
Authors:van Agthoven, J, Arnaout, M.A.
Deposit date:2018-12-05
Release date:2019-12-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-guided design of pure orthosteric inhibitors of alpha IIb beta 3 that prevent thrombosis but preserve hemostasis.
Nat Commun, 11, 2020
6PYH
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BU of 6pyh by Molmil
Cryo-EM structure of full-length IGF1R-IGF1 complex. Only the extracellular region of the complex is resolved.
Descriptor: Insulin-like growth factor 1 receptor, Insulin-like growth factor I
Authors:Li, J, Choi, E, Yu, H.T, Bai, X.C.
Deposit date:2019-07-29
Release date:2019-10-23
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural basis of the activation of type 1 insulin-like growth factor receptor.
Nat Commun, 10, 2019
6PXW
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BU of 6pxw by Molmil
Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the top part of the receptor complex.
Descriptor: Insulin, Insulin receptor
Authors:Uchikawa, E, Choi, E, Shang, G.J, Yu, H.T, Bai, X.C.
Deposit date:2019-07-28
Release date:2019-09-04
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex.
Elife, 8, 2019
7OPB
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BU of 7opb by Molmil
IL7R in complex with an antagonist
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, IL7R binder, ...
Authors:Markovic, I, Verschueren, K.H.G, Verstraete, K, Savvides, S.N.
Deposit date:2021-05-31
Release date:2022-05-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.144 Å)
Cite:Design of protein-binding proteins from the target structure alone.
Nature, 605, 2022
1BQU
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BU of 1bqu by Molmil
CYTOKYNE-BINDING REGION OF GP130
Descriptor: GLYCEROL, PROTEIN (GP130), SULFATE ION
Authors:Bravo, J, Staunton, D, Heath, J.K, Jones, E.Y.
Deposit date:1998-08-18
Release date:1998-08-26
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a cytokine-binding region of gp130.
EMBO J., 17, 1998
2X10
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BU of 2x10 by Molmil
Crystal structure of the complete EphA2 ectodomain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, EPHRIN TYPE-A RECEPTOR 2
Authors:Seiradake, E, Harlos, K, Sutton, G, Aricescu, A.R, Jones, E.Y.
Deposit date:2009-12-21
Release date:2010-03-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:An Extracellular Steric Seeding Mechanism for Eph-Ephrin Signalling Platform Assembly
Nat.Struct.Mol.Biol., 17, 2010
4K0V
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BU of 4k0v by Molmil
Structural basis for angiopoietin-1 mediated signaling initiation
Descriptor: Angiopoietin-1, TEK tyrosine kinase variant
Authors:Yu, X, Seegar, T.C.M, Dalton, A.C, Tzvetkova-Robev, D, Goldgur, Y, Nikolov, D.B, Barton, W.A.
Deposit date:2013-04-04
Release date:2013-05-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (4.51 Å)
Cite:Structural basis for angiopoietin-1-mediated signaling initiation.
Proc.Natl.Acad.Sci.USA, 110, 2013
1AXI
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BU of 1axi by Molmil
STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE
Descriptor: GROWTH HORMONE, GROWTH HORMONE RECEPTOR, SULFATE ION
Authors:Atwell, S, Ultsch, M, De Vos, A.M, Wells, J.A.
Deposit date:1997-10-15
Release date:1998-01-28
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural plasticity in a remodeled protein-protein interface.
Science, 278, 1997
7PG2
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BU of 7pg2 by Molmil
Low resolution Cryo-EM structure of full-length insulin receptor bound to 3 insulin, conf 1
Descriptor: Insulin, Isoform Short of Insulin receptor
Authors:Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P.
Deposit date:2021-08-12
Release date:2022-02-02
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling.
J.Mol.Biol., 434, 2022
7PG0
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BU of 7pg0 by Molmil
Low resolution Cryo-EM structure of full-length insulin receptor bound to 3 insulin with visible ddm micelle, conf 1
Descriptor: Insulin, Isoform Short of Insulin receptor
Authors:Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P.
Deposit date:2021-08-12
Release date:2022-02-02
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (7.6 Å)
Cite:Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling.
J.Mol.Biol., 434, 2022
7PG4
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BU of 7pg4 by Molmil
Low resolution Cryo-EM structure of the full-length insulin receptor bound to 2 insulin, conf 3
Descriptor: Insulin, Isoform Short of Insulin receptor
Authors:Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P.
Deposit date:2021-08-12
Release date:2022-02-02
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (9.1 Å)
Cite:Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling.
J.Mol.Biol., 434, 2022
7PG3
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BU of 7pg3 by Molmil
Low resolution Cryo-EM structure of the full-length insulin receptor bound to 3 insulin, conf 2
Descriptor: Insulin, Isoform Short of Insulin receptor
Authors:Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P.
Deposit date:2021-08-12
Release date:2022-02-02
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (7.3 Å)
Cite:Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling.
J.Mol.Biol., 434, 2022
2Q7N
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BU of 2q7n by Molmil
Crystal structure of Leukemia inhibitory factor in complex with LIF receptor (domains 1-5)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Huyton, T, Zhang, J.G, Nicola, N.A, Garrett, T.P.J.
Deposit date:2007-06-07
Release date:2007-07-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (4 Å)
Cite:An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor.
Proc.Natl.Acad.Sci.USA, 104, 2007
2XYC
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BU of 2xyc by Molmil
CRYSTAL STRUCTURE OF NCAM2 IGIV-FN3I
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, NEURAL CELL ADHESION MOLECULE 2, ...
Authors:Kulahin, N, Rasmussen, K.K, Kristensen, O, Berezin, V, Bock, E, Walmod, P.S, Gajhede, M.
Deposit date:2010-11-17
Release date:2011-02-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural Model and Trans-Interaction of the Entire Ectodomain of the Olfactory Cell Adhesion Molecule.
Structure, 19, 2011
7QID
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BU of 7qid by Molmil
tentative model of the human insulin receptor ectodomain bound by three insulin
Descriptor: Insulin, Insulin receptor, Isoform Short of Insulin receptor
Authors:Gutman, T, Schaefer, I.B, Poojari, C.S, Vattulainen, I, Strauss, M, Coskun, U.
Deposit date:2021-12-14
Release date:2022-02-02
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain
J Cell Biol, 219, 2020
6P67
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BU of 6p67 by Molmil
Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha 2B8 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-IL-7R 2B8 Fab heavy chain, ...
Authors:Walsh, S.T.R, Kashi, L, Kohnhorst, C.L.
Deposit date:2019-06-03
Release date:2019-09-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:New anti-IL-7R alpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models.
Leukemia, 34, 2020
6P50
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BU of 6p50 by Molmil
Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha Fab 4A10
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-7 receptor subunit alpha, anti-IL-7R 4A10 Fab heavy chain, ...
Authors:Walsh, S.T.R, Kashi, L, Kohnhorst, C.L.
Deposit date:2019-05-29
Release date:2019-09-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:New anti-IL-7R alpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models.
Leukemia, 34, 2020
2X11
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BU of 2x11 by Molmil
Crystal structure of the complete EphA2 ectodomain in complex with ephrin A5 receptor binding domain
Descriptor: EPHRIN TYPE-A RECEPTOR 2, EPHRIN-A5
Authors:Seiradake, E, Harlos, K, Sutton, G, Aricescu, A.R, Jones, E.Y.
Deposit date:2009-12-21
Release date:2010-03-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (4.83 Å)
Cite:An Extracellular Steric Seeding Mechanism for Eph-Ephrin Signalling Platform Assembly
Nat.Struct.Mol.Biol., 17, 2010

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數據於2024-06-26公開中

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