2QQH
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5OUP
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![BU of 5oup by Molmil](/molmil-images/mine/5oup) | Structure of TgPLP1 MACPF domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Perforin-like protein 1 | Authors: | Ni, T, Gilbert, R.J.C. | Deposit date: | 2017-08-24 | Release date: | 2018-04-11 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Structures of monomeric and oligomeric forms of theToxoplasma gondiiperforin-like protein 1. Sci Adv, 4, 2018
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5J69
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5OWN
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![BU of 5own by Molmil](/molmil-images/mine/5own) | Structure of TgPLP1 MACPF domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Perforin-like protein 1 | Authors: | Ni, T, Gilbert, R.J.C. | Deposit date: | 2017-09-01 | Release date: | 2018-04-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.11 Å) | Cite: | Structures of monomeric and oligomeric forms of theToxoplasma gondiiperforin-like protein 1. Sci Adv, 4, 2018
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5OUQ
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![BU of 5ouq by Molmil](/molmil-images/mine/5ouq) | Structure of TgPLP1 MACPF domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Perforin-like protein 1 | Authors: | Ni, T, Gilbert, R.J.C. | Deposit date: | 2017-08-24 | Release date: | 2018-04-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (5.11 Å) | Cite: | Structures of monomeric and oligomeric forms of theToxoplasma gondiiperforin-like protein 1. Sci Adv, 4, 2018
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6SB3
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![BU of 6sb3 by Molmil](/molmil-images/mine/6sb3) | |
6SB5
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6U2J
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![BU of 6u2j by Molmil](/molmil-images/mine/6u2j) | EM structure of MPEG-1 (L425K, alpha conformation) soluble pre-pore complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein | Authors: | Pang, S.S, Bayly-Jones, C. | Deposit date: | 2019-08-20 | Release date: | 2019-09-25 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (2.37 Å) | Cite: | The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1. Nat Commun, 10, 2019
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6U2W
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![BU of 6u2w by Molmil](/molmil-images/mine/6u2w) | EM structure of MPEG-1(L425K) pre-pore complex bound to liposome | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein | Authors: | Pang, S.S, Bayly-Jones, C. | Deposit date: | 2019-08-20 | Release date: | 2019-09-25 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.63 Å) | Cite: | The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1. Nat Commun, 10, 2019
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6U23
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![BU of 6u23 by Molmil](/molmil-images/mine/6u23) | EM structure of MPEG-1(w.t.) soluble pre-pore | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein | Authors: | Pang, S.S, Bayly-Jones, C. | Deposit date: | 2019-08-19 | Release date: | 2019-09-25 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1. Nat Commun, 10, 2019
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6U2L
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![BU of 6u2l by Molmil](/molmil-images/mine/6u2l) | EM structure of MPEG-1 (L425K, beta conformation) soluble pre-pore complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein | Authors: | Pang, S.S, Bayly-Jones, C. | Deposit date: | 2019-08-20 | Release date: | 2019-09-25 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1. Nat Commun, 10, 2019
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6U2K
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8A1S
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![BU of 8a1s by Molmil](/molmil-images/mine/8a1s) | Structure of murine perforin-2 (Mpeg1) pore in twisted form | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein | Authors: | Yu, X, Ni, T, Zhang, P, Gilbert, R. | Deposit date: | 2022-06-02 | Release date: | 2022-07-20 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation. Embo J., 41, 2022
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8A1D
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![BU of 8a1d by Molmil](/molmil-images/mine/8a1d) | Structure of murine perforin-2 (Mpeg1) pore in ring form | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, Macrophage-expressed gene 1 protein | Authors: | Yu, X, Ni, T, Zhang, P, Gilbert, R. | Deposit date: | 2022-06-01 | Release date: | 2022-07-20 | Last modified: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation. Embo J., 41, 2022
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2QP2
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![BU of 2qp2 by Molmil](/molmil-images/mine/2qp2) | Structure of a MACPF/perforin-like protein | Descriptor: | CALCIUM ION, Unknown protein | Authors: | Rosado, C.J, Buckle, A.M, Law, R.H.P, Butcher, R.E, Kan, W.T, Bird, C.H, Ung, K, Browne, K.A, Baran, K, Bashtannyk-Puhalovich, T.A, Faux, N.G, Wong, W, Porter, C.J, Pike, R.N, Ellisdon, A.M, Pearce, M.C, Bottomley, S.P, Emsley, J, Smith, A.I, Rossjohn, J, Hartland, E.L, Voskoboinik, I, Trapani, J.A, Bird, P.I, Dunstone, M.A, Whisstock, J.C. | Deposit date: | 2007-07-22 | Release date: | 2007-09-04 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A common fold mediates vertebrate defense and bacterial attack Science, 317, 2007
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5J67
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![BU of 5j67 by Molmil](/molmil-images/mine/5j67) | Structure of Astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Astrotactin-2, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... | Authors: | Ni, T, Harlos, K, Gilbert, R.J.C. | Deposit date: | 2016-04-04 | Release date: | 2016-05-25 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.16 Å) | Cite: | Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development. Open Biology, 6, 2016
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6FBM
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5J68
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![BU of 5j68 by Molmil](/molmil-images/mine/5j68) | Structure of Astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Astrotactin-2, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... | Authors: | Ni, T, Harlos, K, Gilbert, R.J.C. | Deposit date: | 2016-04-04 | Release date: | 2016-05-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (5.221 Å) | Cite: | Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development. Open Biology, 6, 2016
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8B6U
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![BU of 8b6u by Molmil](/molmil-images/mine/8b6u) | Mpf2Ba1 monomer | Descriptor: | MAGNESIUM ION, Mpf2Ba1 | Authors: | Marini, G, Poland, B, Leininger, C, Lukoyanova, N, Spielbauer, D, Barry, J, Altier, D, Lum, A, Scolaro, E, Perez-Ortega, C, Yalpani, N, Sandahl, G, Mabry, T, Klever, J, Nowatzki, T, Zhao, J.Z, Sethi, A, Kassa, A, Crane, V, Lu, A, Nelson, M.E, Eswar, N, Topf, M, Saibil, H.R. | Deposit date: | 2022-09-27 | Release date: | 2023-05-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.134 Å) | Cite: | Structural journey of an insecticidal protein against western corn rootworm. Nat Commun, 14, 2023
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8B6W
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![BU of 8b6w by Molmil](/molmil-images/mine/8b6w) | Mpf2Ba1 pore | Descriptor: | MAGNESIUM ION, Mpf2Ba1 | Authors: | Marini, G, Poland, B, Leininger, C, Lukoyanova, N, Spielbauer, D, Barry, J, Altier, D, Lum, A, Scolaro, E, Perez Ortega, C, Yalpani, N, Sandahl, G, Mabry, T, Klever, J, Nowatzki, T, Zhao, J.Z, Sethi, A, Kassa, A, Crane, V, Lu, A, Nelson, M.E, Eswar, N, Topf, M, Saibil, H.R. | Deposit date: | 2022-09-27 | Release date: | 2023-05-31 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural journey of an insecticidal protein against western corn rootworm. Nat Commun, 14, 2023
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8B6V
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![BU of 8b6v by Molmil](/molmil-images/mine/8b6v) | Mp2Ba1 pre-pore | Descriptor: | MAGNESIUM ION, Mpf2Ba1 | Authors: | Marini, G, Poland, B, Leininger, C, Lukoyanova, N, Spielbauer, D, Barry, J, Altier, D, Lum, A, Scolaro, E, Perez Ortega, C, Yalpani, N, Sandahl, G, Mabry, T, Klever, J, Nowatzki, T, Zhao, J.Z, Sethi, A, Kassa, A, Crane, V, Lu, A, Nelson, M.E, Eswar, N, Topf, M, Saibil, H.R. | Deposit date: | 2022-09-27 | Release date: | 2023-05-31 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural journey of an insecticidal protein against western corn rootworm. Nat Commun, 14, 2023
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2RD7
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![BU of 2rd7 by Molmil](/molmil-images/mine/2rd7) | Human Complement Membrane Attack Proteins Share a Common Fold with Bacterial Cytolysins | Descriptor: | CHLORIDE ION, Complement component C8 alpha chain, Complement component C8 gamma chain | Authors: | Slade, D.J, Lovelace, L.L, Chruszcz, M, Minor, W, Lebioda, L, Sodetz, J.M. | Deposit date: | 2007-09-21 | Release date: | 2008-05-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement. J. Biol. Chem., 286, 2011
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8DE6
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![BU of 8de6 by Molmil](/molmil-images/mine/8de6) | Oligomeric C9 in complex with aE11 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement component C9, ... | Authors: | Bayly-Jones, C. | Deposit date: | 2022-06-20 | Release date: | 2023-01-25 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9. Commun Biol, 6, 2023
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4E0S
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![BU of 4e0s by Molmil](/molmil-images/mine/4e0s) | Crystal Structure of C5b-6 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C5, ... | Authors: | Aleshin, A.E, Stec, B, DiScipio, R, Liddington, R.C. | Deposit date: | 2012-03-05 | Release date: | 2012-04-18 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (4.21 Å) | Cite: | Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex. J.Biol.Chem., 287, 2012
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5FMW
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![BU of 5fmw by Molmil](/molmil-images/mine/5fmw) | The poly-C9 component of the Complement Membrane Attack Complex | Descriptor: | POLYC9 | Authors: | Dudkina, N.V, Spicer, B.A, Reboul, C.F, Conroy, P.J, Lukoyanova, N, Elmlund, H, Law, R.H.P, Ekkel, S.M, Kondos, S.C, Goode, R.J.A, Ramm, G, Whisstock, J.C, Saibil, H.R, Dunstone, M.A. | Deposit date: | 2015-11-10 | Release date: | 2016-02-17 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (6.7 Å) | Cite: | Structure of the Poly-C9 Component of the Complement Membrane Attack Complex Nat.Commun., 7, 2016
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