6SB5

CryoEM structure of murine perforin-2 ectodomain in a pore form

Summary for 6SB5

Entry DOI	10.2210/pdb6sb5/pdb
EMDB information	10135
Descriptor	Macrophage-expressed gene 1 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
Functional Keywords	pore-forming protein, pre-pore, macpf, toxin
Biological source	Mus musculus (House mouse)
Total number of polymer chains	16
Total formula weight	1145151.15
Authors	Ni, T.,Yu, X.,Gilbert, R.J.C. (deposition date: 2019-07-18, release date: 2020-02-05, Last modification date: 2020-07-29)
Primary citation	Ni, T.,Jiao, F.,Yu, X.,Aden, S.,Ginger, L.,Williams, S.I.,Bai, F.,Prazak, V.,Karia, D.,Stansfeld, P.,Zhang, P.,Munson, G.,Anderluh, G.,Scheuring, S.,Gilbert, R.J.C. Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity. Sci Adv, 6:eaax8286-eaax8286, 2020 Cited by PubMed: 32064340 DOI: 10.1126/sciadv.aax8286 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (5 Å)

Structure validation