Crystal Structure of C5b-6

Summary for 4E0S

DescriptorComplement C5, Complement component C6, N-ACETYL-D-GLUCOSAMINE, ... (8 entities in total)
Functional Keywordscomplement, mac, immune system
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01031 P13671
Total number of polymer chains2
Total molecular weight293080.27
Aleshin, A.E.,Stec, B.,DiScipio, R.,Liddington, R.C. (deposition date: 2012-03-05, release date: 2012-04-18, Last modification date: 2017-11-15)
Primary citation
Aleshin, A.E.,Discipio, R.G.,Stec, B.,Liddington, R.C.
Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex.
J.Biol.Chem., 287:19642-19652, 2012
PubMed: 22500023 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M112.361121
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.281412.5%12.8%0.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload