6U2L

EM structure of MPEG-1 (L425K, beta conformation) soluble pre-pore complex

This is a large structure.

Summary for 6U2L

EMDB information20617 20616 20619 20620 20621 20623 20622
DescriptorMacrophage-expressed gene 1 protein, N-ACETYL-D-GLUCOSAMINE (2 entities in total)
Functional Keywordsmpeg-1/perforin-2, macpf, macrophage, pore forming proteins, immunity, immune system
Biological sourceHomo sapiens (Human)
Total number of polymer chains32
Total molecular weight2297272.7
Authors
Pang, S.S.,Bayly-Jones, C. (deposition date: 2019-08-20, release date: 2019-09-25, Last modification date: 2019-10-02)
Primary citation
Pang, S.S.,Bayly-Jones, C.,Radjainia, M.,Spicer, B.A.,Law, R.H.P.,Hodel, A.W.,Parsons, E.S.,Ekkel, S.M.,Conroy, P.J.,Ramm, G.,Venugopal, H.,Bird, P.I.,Hoogenboom, B.W.,Voskoboinik, I.,Gambin, Y.,Sierecki, E.,Dunstone, M.A.,Whisstock, J.C.
The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10:4288-4288, 2019
PubMed: 31537793 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-019-12279-2
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY
?

Structure validation

ClashscoreRamachandran outliersSidechain outliers30 1.1%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures