6U2W

EM structure of MPEG-1(L425K) pre-pore complex bound to liposome

Summary for 6U2W

• Entry DOI: 10.2210/pdb6u2w/pdb
• EMDB information: 20627
• Descriptor: Macrophage-expressed gene 1 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
• Functional Keywords: mpeg-1/perforin-2, macpf, macrophage, pore forming proteins, immunity, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 16
• Total formula weight: 1151599.20

Authors

Pang, S.S.,Bayly-Jones, C. (deposition date: 2019-08-20, release date: 2019-09-25, Last modification date: 2020-07-29)

• Primary citation: Pang, S.S.,Bayly-Jones, C.,Radjainia, M.,Spicer, B.A.,Law, R.H.P.,Hodel, A.W.,Parsons, E.S.,Ekkel, S.M.,Conroy, P.J.,Ramm, G.,Venugopal, H.,Bird, P.I.,Hoogenboom, B.W.,Voskoboinik, I.,Gambin, Y.,Sierecki, E.,Dunstone, M.A.,Whisstock, J.C.; The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.; Nat Commun, 10:4288-4288, 2019; PubMed: 31537793; DOI: 10.1038/s41467-019-12279-2

Experimental method

ELECTRON MICROSCOPY (3.63 Å)